NOS1 Inhibitors
Santa Cruz Biotechnology now offers a broad range of NOS1 Inhibitors. Nitric oxide (NO) has a broad range of biological activities including cell signaling pathways in phylogenetically diverse species. Nitric oxide synthases (NOSs), the enzymes responsible for synthesis of NO, contain an N-terminal oxygenase domain and a C-terminal reductase domain. NOS1 (also designated ncNOS) is a constitutive Ca2+/CaM-dependent form of NOS, whose activity was first identified in neurons. NOS1 Inhibitors offered by Santa Cruz inhibit NOS1 and, in some cases, other cell signaling and nitric oxide synthesis related proteins. View detailed NOS1 Inhibitor specifications, including NOS1 Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
Items 41 to 50 of 54 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1,4-PB-ITU dihydrobromide | 157254-60-9 | sc-202003 sc-202003A | 10 mg 50 mg | $20.00 $58.00 | ||
1,4-PB-ITU dihydrobromide exhibits a distinctive mechanism of action as a NOS1 inhibitor, primarily through allosteric modulation rather than direct competition at the active site. Its dihydrobromide form enhances solubility and stability, allowing for effective interaction with the enzyme. The compound's unique hydrophobic regions promote favorable van der Waals interactions, which can stabilize specific enzyme conformations, thereby influencing the overall enzymatic activity and regulatory pathways. | ||||||
L-NIL dihydrochloride | 159190-45-1 | sc-205362 sc-205362A | 5 mg 10 mg | $47.00 $80.00 | 1 | |
L-NIL dihydrochloride functions as a selective inhibitor of NOS1, characterized by its ability to disrupt nitric oxide synthesis through a unique binding affinity that alters enzyme conformation. The dihydrochloride form enhances ionic interactions, improving solubility in aqueous environments. This compound's structural features facilitate specific hydrogen bonding, which can modulate the enzyme's catalytic efficiency and influence downstream signaling pathways, showcasing its intricate role in biochemical regulation. | ||||||
S-Ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea hydrochloride | 163490-78-6 | sc-222274 sc-222274A | 5 mg 25 mg | $23.00 $82.00 | ||
S-Ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea hydrochloride exhibits a distinctive mechanism as a NOS1 inhibitor, characterized by its trifluoromethyl group that enhances lipophilicity and alters electronic properties. This compound engages in specific π-π stacking interactions with aromatic residues, influencing the enzyme's active site dynamics. Its unique isothiourea moiety promotes strong hydrogen bonding, potentially stabilizing enzyme conformations and modulating nitric oxide production pathways. | ||||||
N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N′-nitroguanidine tris(trifluoroacetate) salt | 357965-99-2 | sc-215427 sc-215427A | 5 mg 25 mg | $148.00 $719.00 | 3 | |
N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N'-nitroguanidine tris(trifluoroacetate) salt operates as a NOS1 modulator through its nitroguanidine structure, which facilitates unique electrostatic interactions with the enzyme's active site. The trifluoroacetate component enhances solubility and bioavailability, while the amino groups contribute to intricate hydrogen bonding networks. This compound's ability to alter conformational dynamics may significantly impact nitric oxide synthesis pathways. | ||||||
1,3-PBITU, Dihydrobromide | sc-3568 | 10 mg | $20.00 | 1 | ||
1,3-PBITU, Dihydrobromide acts as a NOS1 modulator by engaging in specific ionic interactions due to its dihydrobromide moiety, which enhances its solubility in polar environments. The compound's unique structure allows for selective binding to the enzyme, influencing its conformational stability and catalytic efficiency. Additionally, the presence of bromide ions may facilitate unique reaction kinetics, potentially altering the dynamics of nitric oxide production in cellular pathways. | ||||||
L-thiocitrulline, Dihydrochloride | 212051-53-1 | sc-3572 sc-3572A | 10 mg 50 mg | $62.00 $245.00 | ||
L-thiocitrulline, Dihydrochloride functions as a NOS1 modulator through its distinctive thiol group, which promotes unique redox interactions with the enzyme. This compound exhibits enhanced reactivity due to its dihydrochloride form, allowing for effective protonation states that influence binding affinity. Its ability to form transient complexes with NOS1 can lead to altered enzymatic activity, impacting nitric oxide synthesis and downstream signaling pathways. | ||||||
Propenyl-L-NIO (hydrochloride) | sc-222191 sc-222191A | 5 mg 10 mg | $67.00 $127.00 | |||
Propenyl-L-NIO (hydrochloride) acts as a selective modulator of NOS1 by engaging in specific non-covalent interactions with the enzyme's active site. Its unique propenyl group facilitates conformational changes, enhancing binding dynamics and influencing reaction kinetics. The hydrochloride form increases solubility, promoting efficient diffusion and interaction with NOS1. This compound's distinct structural features enable it to fine-tune nitric oxide production, impacting various cellular signaling mechanisms. | ||||||
Methyl-L-NIO Hydrochloride | 150403-96-6 | sc-205389 sc-205389A | 5 mg 10 mg | $66.00 $126.00 | ||
Methyl-L-NIO Hydrochloride selectively targets NOS1 through intricate molecular interactions that stabilize the enzyme's conformation. The methyl group enhances hydrophobic interactions, optimizing binding affinity and altering the enzyme's catalytic efficiency. Its hydrochloride form improves solubility, allowing for rapid cellular uptake and interaction. This compound's unique structural characteristics enable it to modulate nitric oxide synthesis, influencing diverse biochemical pathways and cellular responses. | ||||||
Ethyl-L-NIO, hydrochloride | 150403-97-7 | sc-223979 sc-223979A | 5 mg 10 mg | $56.00 $107.00 | ||
Ethyl-L-NIO, hydrochloride exhibits a unique ability to modulate NOS1 activity through specific interactions that influence the enzyme's structural dynamics. The ethyl group introduces steric effects that can alter the enzyme's active site accessibility, impacting substrate binding and reaction kinetics. Its hydrochloride form enhances ionic interactions, promoting solubility and facilitating effective cellular penetration. This compound's distinct properties allow it to engage in complex biochemical signaling pathways, affecting nitric oxide production. | ||||||
S-Methyl-L-thiocitrulline acetate salt | 174063-92-4 | sc-215830 sc-215830A | 10 mg 50 mg | $87.00 $281.00 | 2 | |
S-Methyl-L-thiocitrulline acetate salt is characterized by its ability to selectively inhibit NOS1 through unique thiol interactions that stabilize the enzyme's conformation. The methyl group enhances hydrophobic interactions, influencing the binding affinity and altering the enzyme's catalytic efficiency. Its acetate salt form increases solubility, promoting effective distribution in biological systems. This compound's distinct molecular behavior allows it to intricately modulate nitric oxide synthesis pathways. | ||||||