Propenyl-L-NIO (hydrochloride) (ENIPO) is a potent, selective inhibitor of NOS2 (iNOS). The Ki values for inhibition of NOS2, NOS1 (nNOS), and NOS3 (eNOS) by ENIPO are 17, 10.3 and 58.2 µM, respectively, as determined using initial rate binding kinetics. However, ENIPO is a time-dependent inhibitor that, with longer incubations, demonstrates reversible tight binding inhibition that is selective for NOS2 over NOS1 or NOS3. This selectivity results from NOS2 exhibiting a 4-fold faster binding and 10-fold slower dissociation with ENIPO compared to NOS1. Ki values for ENIPO binding to NOS2 and NOS1 are 0.56 and 6 µM, respectively. Accurate determination of the Ki value of ENIPO for NOS3 has not been determined but is expected to be 50-fold less than NOS2.
1 Bretscher, L.E., Li, H., Poulos, T.L., et al. Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines. J Biol Chem 278(47) 46789-46797 (2003)
산타크루즈바이오테크놀러지는 생물의학연구에 필요한 제품을 개발하는 선구자입니다. Toll Free 1-800-457-3801로 연락주세요. Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. 판권소유. "Santa Cruz Biotechnology", 와 Santa Cruz Biotechnology, Inc. 로고, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", 및 San Juan Ranch 로고, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz"와 "EZ Touch" 는 Santa Cruz Biotechnology, Inc의 등록된 상표입니다. 모든 상표는 각자 소유주의 소유입니다.