MDMX Activators
MDMX Activators represent a distinct class of chemical compounds that play a crucial role in the field of molecular biology and cellular regulation. These compounds are specifically designed to target and modify the activity of the MDMX protein, also known as Murine Double Minute 4 (MDM4). MDMX is a key player in cellular processes, particularly in its interaction with the tumor suppressor protein p53. Unlike its close counterpart MDM2, MDMX lacks the ability to degrade p53, but it exerts control over p53 by binding to and inhibiting its transcriptional activity. MDMX Activators aim to modulate this interaction, restoring balance within the cellular regulatory network.
These compounds primarily function by disrupting the intricate protein-protein interactions between MDMX and p53. By doing so, MDMX Activators can effectively influence the downstream cellular responses governed by p53, such as cell cycle regulation, DNA repair, and programmed cell death. The significance of MDMX Activators lies in their ability to fine-tune these intricate molecular processes without directly targeting any particular ailment or condition. Researchers are continually exploring applications and implications of MDMX Activators in diverse biological contexts, shedding light on the broader understanding of cellular dynamics and molecular mechanisms that underpin various physiological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 disrupts the MDM2-p53 interaction, which can lead to compensatory upregulation of MDMX as a feedback mechanism in certain contexts. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is shown to activate SIRT1, which can modulate the p53 pathway and potentially lead to changes in MDMX expression indirectly. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
This compound can cause DNA damage responses that may incidentally lead to the upregulation of MDMX as part of the cellular stress response. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin induces DNA damage and can affect numerous signaling pathways, potentially leading to an increase in MDMX expression as a cellular defense mechanism. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane affects various cellular pathways, including Nrf2, which may interact with p53 dynamics and influence MDMX levels. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
As an HDAC inhibitor, Suberoylanilide Hydroxamic Acid alters chromatin structure and gene expression, which could include the transcriptional regulation of MDMX. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide induces topoisomerase II-mediated DNA damage, which may result in the upregulation of MDMX expression as a part of the DNA damage response. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine exerts oxidative stress, which may perturb cellular antioxidant defenses and indirectly modulate MDMX expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is known to affect various signaling pathways and could influence MDMX expression through its interaction with the p53 pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin impacts multiple cellular processes, including the modulation of transcription factors that may govern MDMX expression. | ||||||