Piperlongumine CAS: 20069-09-4
MF: C17H19NO5
MW: 317.34
A selective anticancer GSTP1 and Bcl-2 inhibitor.

Piperlongumine (CAS 20069-09-4)

Piperlongumine | CAS 20069-09-4 is rated 5.0 out of 5 by 1.
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Synonym: Piplartine
Application: A selective anticancer GSTP1 and Bcl-2 inhibitor
CAS Number: 20069-09-4
Purity: ≥97%
Molecular Weight: 317.34
Molecular Formula: C17H19NO5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Piperlongumine, isolated from Piper longum, is a cell-permeable inducer of cell-death in cancer cells. It has been shown to inhibit expression of Bcl-2 and enhance wild type p53 expression. Piperlongumine is an inhibitor of GSTP1.

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), ethanol (20 mM with gentle warming), DMF (~20 mg/ml), 1: 10 DMSO: PBS (pH 7.2) (~0.1 mg/ml), and methanol.
Storage :
Store at -20° C
Melting Point :
123-124° C
Boiling Point :
~475.6° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
Trypanosoma cruzi: IC50 = 21 µM
Ki Data :
Platelet aggregation induced by the thromboxane A2 agonist U-46619: Ki= 6.8 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UU7785850
PubChem CID :
637858
MDL Number :
MFCD00075706
SMILES :
COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O

Download SDS (MSDS)

Certificate of Analysis

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mel enviaran desde ALEMANIA?

Asked by: adonis
Thank you for the question. Customers located in Europe will be served by our European Support Office located in Heidelberg Germany. Please contact us to receive a sales quotation with estimated lead time. The product is currently in stock.
Answered by: Technical Support Europe
Date published: 2019-02-11

Dear SCBT Team,  Is product sc-364128 an exact isomer, or a racemate?  Thank you.

Asked by: Peter Zed
Thank you for your question. Please contact our Technical Service Department to request more detailed information about what is in stock currently for this chemical. Please call our European Support office toll-free at 00800 4573 8000, email [email protected], or contact us by live chat.
Answered by: Technical Support
Date published: 2018-09-25
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Rated 5 out of 5 by from Wang et al Wang et al. (PubMed ID 262466196) found that Piperlongumine induced autophagy and apoptosis in lung cancer cells via PI3K/Akt/mTOR pathway inhibition. -SCBT Publication Review
Date published: 2015-04-14
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