GS27 Activators
GS27 Activators are a diverse set of chemical compounds that indirectly enhance the functional activity of GS27 through modulation of various signaling pathways. Forskolin and IBMX raise intracellular cAMP levels, leading to the activation of PKA, which could phosphorylate substrates that are either directly or indirectly involved in enhancing GS27's activity. Similarly, Isoproterenol, a beta-adrenergic agonist, may also boost GS27 activity via the cAMP/PKA signaling pathway. PMA and Phorbol 12-myristate 13-acetate, both activators of PKC, can phosphorylate a range of proteins, potentially including those that regulate GS27's function. Calcium ionophores like Ionomycin and A23187 significantly increase intracellular calcium levels, activating calcium-dependent proteins that may interact with GS27, thereby enhancing its activity. LY294002, by inhibiting PI3K, might disrupt AKT signaling and lead to the enhanced activity of GS27 if it is influenced by this pathway.
In addition to these, Okadaic Acid can inhibit protein phosphatases PP1 and PP2A, which could result in the upregulationof GS27's functional activity if GS27 is regulated by the phosphorylation state of proteins controlled by these phosphatases. Spermine, with its ability to modulate ion channels, might indirectly influence GS27 activity by inducing changes in intracellular signaling cascades that GS27 is part of. Anisomycin, an activator of stress-activated protein kinases, might potentiate GS27's activity if GS27 is involved in stress response signaling pathways. Finally, Zaprinast's inhibition of PDE5 and subsequent increase in cAMP and cGMP levels could lead to the activation of cGMP-dependent pathways, thereby enhancing the activity of GS27. Through these varied mechanisms involving alterations in phosphorylation states, modulation of ion concentrations, and changes in secondary messenger levels, these chemical activators collectively promote the enhanced activity of GS27 without directly increasing its expression or requiring direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can activate PKA. PKA is known to phosphorylate various substrates, and if GS27 is a substrate or is regulated by a PKA-phosphorylated protein, this would lead to the enhancement of GS27's activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterase, leading to elevated cAMP levels. This increase can indirectly enhance the activity of GS27 if GS27 is involved in cAMP-dependent signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is an activator of protein kinase C (PKC), which can phosphorylate a multitude of proteins. If GS27 activity is modulated by PKC or by proteins that are substrates of PKC, PMA would enhance GS27 functional activity. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that significantly increases intracellular calcium levels, which can activate calcium-dependent proteins. If GS27's activity is regulated by calcium signaling, ionomycin would enhance its functional activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore that raises intracellular calcium levels. It activates calcium-dependent signaling pathways, potentially enhancing GS27 activity if it is calcium-dependent. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter downstream signaling, including AKT pathway. If GS27 is indirectly activated via PI3K/AKT signaling, this compound could lead to the enhancement of GS27 activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A, altering the phosphorylation state of proteins. This could enhance GS27 activity if it is regulated by proteins that are substrates of these phosphatases. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, potentially enhancing GS27 activity through the cAMP/PKA signaling pathway. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine can modulate ion channels and may influence intracellular signaling cascades. If GS27 activity is modulated by ionic changes or signaling pathways affected by spermine, it could lead to enhanced GS27 activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases (SAPKs), and if GS27 is part of pathways influenced by SAPKs, its functional activity could be enhanced. | ||||||