Date published: 2026-2-23

1-800-457-3801

SCBT Portrait Logo
Seach Input

Ionomycin, free acid (CAS 56092-81-0)

5.0(2)
Write a reviewAsk a question

See product citations (2)

Alternate Names:
Ionomycin, free acid, is also known as SQ 23377.
Application:
Ionomycin free acid is a potent and selective calcium ionophore antibiotic, able to extract calcium ions from aqueous phase to organic phase.
CAS Number:
56092-81-0
Molecular Weight:
709.01
Molecular Formula:
C41H72O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Ionomycin free acid is an antibiotic selective calcium ionophore. Ionomycin free acid can extract calcium ions from aqueous phase to organic phase. In addition, Ionomycin free acid acts as a transport carrier, which helps transport cations across solvent barriers. Studies indicate that Ionomycin free acid can transport other ions such as Mg, Sr, and Ba with a weaker affinity. It is known that Ionomycin free acid is produced by Streptomyces conglobatus. Furthermore, Ionomycin free acid is a beneficial tool in research to raise intracellular calcium levels. Finally, Ionomycin free acid can be used to study the calcium transport across the plasma membrane.


Ionomycin, free acid (CAS 56092-81-0) References

  1. Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils.  |  Elzi, DJ., et al. 2001. Am J Physiol Cell Physiol. 281: C350-60. PMID: 11401859
  2. Effects of repetitive ionomycin treatment on in vitro development of bovine somatic cell nuclear transfer embryos.  |  Kim, HS., et al. 2012. J Reprod Dev. 58: 132-9. PMID: 22134064
  3. Effects of ionomycin on egg activation and early development in starfish.  |  Vasilev, F., et al. 2012. PLoS One. 7: e39231. PMID: 22723970
  4. Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes.  |  Zheng, W., et al. 2013. Diabetologia. 56: 401-11. PMID: 23178929
  5. Complex actions of ionomycin in cultured cerebellar astrocytes affecting both calcium-induced calcium release and store-operated calcium entry.  |  Müller, MS., et al. 2013. Neurochem Res. 38: 1260-5. PMID: 23519933
  6. Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release.  |  Zhang, Z., et al. 2014. PLoS One. 9: e94574. PMID: 24718602
  7. A Ca(2+) concentration of 1.5 mM, as present in IMDM but not in RPMI, is critical for maximal response of Th cells to PMA/ionomycin.  |  Zimmermann, J., et al. 2015. Eur J Immunol. 45: 1270-3. PMID: 25545753
  8. Quantification of Th1 and Th17 Cells with Intracellular Staining Following PMA/Ionomycin Stimulation.  |  Karlsson, F. and Hassan-Zahraee, M. 2015. Curr Protoc Cytom. 71: 6.35.1-6.35.7. PMID: 25559223
  9. Proteomics of ionomycin-induced ascidian sperm reaction: Released and exposed sperm proteins in the ascidian Ciona intestinalis.  |  Nakazawa, S., et al. 2015. Proteomics. 15: 4064-79. PMID: 26223815
  10. Effect of ionomycin on interaction of calnexin with vesicular stomatitis virus glycoprotein is cell type-specific.  |  Okudera, M., et al. 2015. J Oral Sci. 57: 305-12. PMID: 26666853
  11. Ionomycin Treatment Renders NK Cells Hyporesponsive.  |  Romera-Cárdenas, G., et al. 2016. PLoS One. 11: e0150998. PMID: 27007115
  12. Ionomycin induces prostaglandin E2 formation in murine osteoblastic MC3T3-E1 cells via mechanisms independent of its ionophoric nature.  |  Leis, HJ. and Windischhofer, W. 2016. Biochem Cell Biol. 94: 236-40. PMID: 27065246
  13. Ionomycin-induced calcium influx induces neurite degeneration in mouse neuroblastoma cells: analysis of a time-lapse live cell imaging system.  |  Nakamura, S., et al. 2016. Free Radic Res. 50: 1214-1225. PMID: 27573976
  14. Characterization of ionomycin as a calcium ionophore.  |  Liu, C. and Hermann, TE. 1978. J Biol Chem. 253: 5892-4. PMID: 28319
  15. Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.  |  Kauffman, RF., et al. 1980. J Biol Chem. 255: 2735-9. PMID: 6766939

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ionomycin, free acid, 1 mg

sc-263405
1 mg
$96.00

Ionomycin, free acid, 5 mg

sc-263405A
5 mg
$264.00

Dear officer Could you please the protocol for inomycin ? THAN KYOU

Asked by: Cansu
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Tech Service 1
Date published: 2021-01-21
  • y_2026, m_2, d_22, h_8CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_263405, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 100ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from worked for flow cytometry for ion stimulationworked for flow cytometry for ion stimulation. Highly recommended.
Date published: 2019-12-04
Rated 5 out of 5 by from Elzi et alElzi et al. (PubMed ID 11401859) found that the ionophore, ionomycin, activated the p38 and p42/44 mitogen-activated kinases in human neutrophils. -SCBT Publication Review
Date published: 2015-01-19
  • y_2026, m_2, d_22, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_263405, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 16ms
  • REVIEWS, PRODUCT
Ionomycin, free acid is rated 5.0 out of 5 by 2.
  • y_2026, m_2, d_22, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_263405, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 98ms
  • REVIEWS, PRODUCT