Date published: 2025-11-21

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Okadaic Acid (CAS 78111-17-8)

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Alternate Names:
Okadaic Acid is also known as OA and NSC 677083.
Application:
Okadaic Acid® is a naturally occurring polyether toxin that acts as a reversible, potent and selective inhibitor of protein phosphatatses.
CAS Number:
78111-17-8
Purity:
>98%
Molecular Weight:
805.00
Molecular Formula:
C44H68O13
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Okadaic acid is a naturally occurring polyether toxin found in marine dinoflagellates, Prorocentrium spp.. Okadaic Acid is a reversible, potent and selective inhibitor of two serine threonine protein phosphatases: PP2A-C (PP2A) which is inhibited completely at 1 nM and PP1 which is inhibited at higher concentrations (IC50= 10-15 nM). PP2B is much less sensitive to okadaic acid than PP1, while PP2C is not inhibited. This selectivity is the basis for an improved identification and quantification procedure for these enzymes. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. Okadaic Acid mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. Okadaic Acid is an activator of PKC. Alternate designations for Okadaic Acid include (2R)-3-[(2S,6R,8S,11R)-2-[(E,1R)-3-[(2S,2primeR,4R,4aS,6R,8aR)-4-Hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylene-spiro[4a,7,8,8a-tetrahydro-4H-pyrano[2,3-e]pyran-6,5′-tetrahydrofuran]-2′-yl]-1-methyl-prop-2-enyl]-11-hydroxy-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-hydroxy-2-methyl-propanoic Acid Spiro[furan-2(3H),2′(3′H)-pyrano[3,2-b]pyran], acanthifolicin deriv. 35-Demethyl-DTX 1 35-Demethyldinophysistoxin 1 and NSC 677083.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

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Okadaic Acid (CAS 78111-17-8) References

  1. Unique features of the okadaic acid activity class of tumor promoters.  |  Fujiki, H. and Suganuma, M. 1999. J Cancer Res Clin Oncol. 125: 150-5. PMID: 10235468
  2. Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1.  |  Maynes, JT., et al. 2001. J Biol Chem. 276: 44078-82. PMID: 11535607
  3. MLH1p and MLH3p localize to precociously induced chiasmata of okadaic-acid-treated mouse spermatocytes.  |  Marcon, E. and Moens, P. 2003. Genetics. 165: 2283-7. PMID: 14704203
  4. Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response.  |  Gehringer, MM. 2004. FEBS Lett. 557: 1-8. PMID: 14741332
  5. Okadaic acid inhibition of KCl cotransport. Evidence that protein dephosphorylation is necessary for activation of transport by either cell swelling or N-ethylmaleimide.  |  Jennings, ML. and Schulz, RK. 1991. J Gen Physiol. 97: 799-817. PMID: 1647439
  6. Protein phosphatase inhibitor okadaic acid enhances transmitter release at neuromuscular junctions.  |  Abdul-Ghani, M., et al. 1991. Proc Natl Acad Sci U S A. 88: 1803-7. PMID: 1672044
  7. Effects of okadaic acid, an inhibitor of protein phosphatases-1 and -2A, on glucose transport and metabolism in skeletal muscle.  |  Tanti, JF., et al. 1991. J Biol Chem. 266: 2099-103. PMID: 1846612
  8. An okadaic acid-induced model of tauopathy and cognitive deficiency.  |  Zhang, Z. and Simpkins, JW. 2010. Brain Res. 1359: 233-46. PMID: 20807517
  9. Okadaic acid: a new probe for the study of cellular regulation.  |  Cohen, P., et al. 1990. Trends Biochem Sci. 15: 98-102. PMID: 2158158
  10. An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues.  |  Cohen, P., et al. 1989. FEBS Lett. 250: 596-600. PMID: 2546812
  11. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism.  |  Haystead, TA., et al. 1989. Nature. 337: 78-81. PMID: 2562908
  12. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.  |  Bialojan, C. and Takai, A. 1988. Biochem J. 256: 283-90. PMID: 2851982
  13. Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin.  |  Takai, A., et al. 1987. FEBS Lett. 217: 81-4. PMID: 3036577
  14. Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.  |  Suganuma, M., et al. 1988. Proc Natl Acad Sci U S A. 85: 1768-71. PMID: 3126494
  15. Evidence for physiological functions of protein phosphatases in the heart: evaluation with okadaic acid.  |  Neumann, J., et al. 1993. Am J Physiol. 265: H257-66. PMID: 8393625

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Okadaic Acid, 25 µg

sc-3513
25 µg
$285.00

Okadaic Acid, 100 µg

sc-3513A
100 µg
$520.00

Okadaic Acid, 1 mg

sc-3513B
1 mg
$1300.00

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. This chemical, Okadaic Acid (CAS 78111-17-8), is soluble in 25 mg/mL DMSO.
Answered by: Chemical Support 1
Date published: 2024-08-19
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Rated 5 out of 5 by from good productThis product works pretty well for our cell culture experiments.
Date published: 2018-05-11
Rated 5 out of 5 by from We used this in WB and cell culture studiesWe used this in WB and cell culture studies and got good results.
Date published: 2015-10-21
Rated 5 out of 5 by from This product has been working really well for usThis product has been working really well for us.
Date published: 2015-04-28
Rated 5 out of 5 by from It worked well without troubleIt worked well without trouble.
Date published: 2015-03-19
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Okadaic Acid is rated 5.0 out of 5 by 4.
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