Isoproterenol Hydrochloride CAS: 51-30-9
MF: C11H17NO3•HCl
MW: 247.72
A selective β-adrenergic agonist.

Isoproterenol Hydrochloride (CAS 51-30-9)

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Alternate Names: Isoprenaline hydrochloride
Application: Isoproterenol Hydrochloride is a selective β-adrenergic agonist
CAS Number: 51-30-9
Purity: ≥97%
Molecular Weight: 247.72
Molecular Formula: C11H17NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Isoproterenol hydrochloride is a phenethylamine derivative and selective β-AR adrenergic agonist shown to increase cytosolic cAMP. Isoproterenol hydrochloride exhibits promotion of glycogen breakdown and causes bronchodilation and vasorelaxant effects. Also potentially stimulates relaxation in nitric oxide mediated endothelium-dependent smooth muscle. Isoproterenol Hydrochloride is an activator of β2-AR and ERK.


References

1. Mokhtari, A., et al. 1985. J. Cyclic Nucleotide Protein Phosphor Res. 10: 213-327. PMID: 2991348
2. von Zastrow, M., et al. 1993. J. Biol. Chem. 268: 763-766. PMID: 7678260
3. Ladenheim, R.G., et al. 1993. J. Neurochem. 60: 260-266. PMID: 8417145
4. Yashiro, K., et al. 1994. J. Biochem. 115: 1040-1046. PMID: 7982879
5. Macaulay, S.L., et al. 1994. Mol. Cell Biochem. 141: 27-33. PMID: 7877606
6. Kishimoto, I., et al. 1994. J. Biol. Chem. 269: 28300-28308. PMID: 7961768
7. Takemura, H., et al. 1995. J. Pharmacol. Exp. Ther. 274: 584-588. PMID: 7616448
8. Schmitt, J.M. and Stork, P.J. 2000. J. Biol. Chem. 275: 25342-25350. PMID: 10840035

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml at 25° C), ethanol (20 mg/ml), methanol, DMSO (50 mg/ml at 25° C), and phosphate buffered saline (50 mM).
Storage :
Store at room temperature
Melting Point :
165-175° C (dec.)
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D 0°
IC50 :
β2-AR: EC5050 = 128.82 nM (human); Plasmodium falciparum: IC50 = 7.94 µM
Ki Data :
β2-AR: Ki= 211.26 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
DO1925000
PubChem CID :
5807
Merck Index :
14: 5217
MDL Number :
MFCD00012603
EC Number :
200-089-8
Beilstein Registry :
3917363
SMILES :
CC(C)NCC(C1=CC(=C(C=C1)O)O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Isoproterenol Hydrochloride (CAS 51-30-9)  Product Citations

See how others have used Isoproterenol Hydrochloride (CAS 51-30-9). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 23442148  Pradhan-Bhatt, S. et al. 2013. Tissue engineering. Part A. 19: 1610-20.

PMID: # 31793297  J. Agric. Food Chem.

Citations 1 to 2 of 2 total
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