Spermine CAS: 71-44-3
MF: C10H26N4
MW: 202.34
A NOS1 inhibitor, NMDA activator, and GluR inhibitor.

Spermine (CAS 71-44-3)

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Synonym: Musculamine; Neuridine
Application: A NOS1 inhibitor, NMDA activator, and GluR inhibitor
CAS Number: 71-44-3
Purity: ≥98%
Molecular Weight: 202.34
Molecular Formula: C10H26N4
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Spermine is a biogenic polyamine formed from spermidine (sc-215900) and occurs in almost all tissues. It is essential for both neoplastic and normal tissue growth and is involved in the modulation of calcium-dependent immune processes. Spermine inhibits NOS1 (nNOS). Spermine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner. Spermine is a GluR inhibitor.


Israel, et al.: J. Med. Chem., 7, 710 (1964), Janne, J., et al.: Biochim. Biophys. Acta, 473, 241 (1978). Theoharides, T.C., et al.: Life Sci., 27, 703 (1980), Horn, Y., et al.: Cancer Res., 42, 3248 (1982),

Physical State :
Low-Melting Solid
Solubility :
Soluble in chloroform, methanol, water, and lower alcohols. Insoluble in ether, benzene, and petroleum ether.
Storage :
Store at 4° C
Melting Point :
28-30° C
Boiling Point :
150° C (lit.) at 5 mmHg
Density :
0.94 g/mL
Refractive Index :
n20D 1.49 (Predicted)
IC50 :
Calf thymus DNA: IC50 = 4.3 µM (Bos taurus); Glutamate NMDA receptor: EC5050 = 5.2 µM (rat)
Ki Data :
T47D (Breast carcinoma cells): Ki= 650 nM (human); Carbonic anhydrase IV: Ki= 10 nM (human); ZR-75-1 (Breast carcinoma cells): Ki= 200 nM (human); MDA-MB-231 (Breast adenocarcinoma cells): Ki= 280 nM (human)
pK Values :
pKb: 10.88 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 8743
MDL Number :
EC Number :
Beilstein Registry :

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Certificate of Analysis

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