D3Ertd254e Activators
Zfp267, a zinc finger protein, plays a pivotal role in the intricate web of cellular regulation by serving as a DNA-binding transcription activator with specificity for RNA polymerase II cis-regulatory region sequences. Predicted to be primarily active in the nucleus, Zfp267 is involved in the regulation of transcription by RNA polymerase II, showcasing its significance in modulating gene expression. The protein's functional attributes suggest a crucial involvement in the intricate orchestration of cellular processes, especially those related to the modulation of RNA polymerase II-mediated transcription.
The activation of Zfp267 involves a multifaceted interplay of diverse cellular mechanisms. Chemical activators influence the expression of Zfp267 through intricate pathways. Epigenetic modifiers, such as histone deacetylase inhibitors, directly impact the chromatin structure, enhancing the accessibility of Zfp267 promoter regions and facilitating transcription. Concurrently, DNA methyltransferase inhibitors and sirtuin inhibitors contribute to the activation by demethylating Zfp267 promoter regions and modulating the NAD+-dependent deacetylase activity, respectively. Additionally, signaling pathway modulators exert indirect control over Zfp267 activation. Inhibitors targeting the p38 MAPK pathway, NF-κB signaling, AMP-activated protein kinase (AMPK), and phosphoinositide 3-kinase (PI3K) influence Zfp267 expression through intricate cellular signaling crosstalk. This intricate network showcases Zfp267 as a hub in cellular regulatory processes, responding to diverse stimuli through different signaling cascades. Overall, the activation of Zfp267 is a nuanced process involving epigenetic modifications, signaling pathway modulation, and intricate interactions within the cellular milieu, highlighting its pivotal role in cellular transcriptional regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, directly activates Zfp267 by inhibiting histone deacetylation. It promotes Zfp267 expression by altering chromatin structure, enhancing accessibility to the gene promoter region. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural polyphenol, indirectly up-regulates Zfp267 by modulating the NF-κB signaling pathway. It inhibits NF-κB, reducing its binding to Zfp267 regulatory regions, leading to increased Zfp267 expression. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
SB203580, a p38 MAPK inhibitor, indirectly stimulates Zfp267 by suppressing the p38 MAPK pathway. This inhibition reduces the phosphorylation of downstream effectors, ultimately enhancing Zfp267 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, directly activates Zfp267 by demethylating its promoter region. This epigenetic modification promotes gene expression by facilitating transcription factor binding. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $182.00 $736.00 | 28 | |
Dorsomorphin, an AMP-activated protein kinase (AMPK) inhibitor, indirectly up-regulates Zfp267 by modulating AMPK signaling. It affects downstream targets, leading to enhanced Zfp267 expression through intricate crosstalk within the cellular signaling network. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol, indirectly activates Zfp267 by inhibiting the mTOR pathway. By suppressing mTOR signaling, it influences the expression of Zfp267 and its downstream targets, contributing to the overall regulation of cellular processes. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1, a bromodomain and extraterminal (BET) protein inhibitor, directly up-regulates Zfp267 by inhibiting BET proteins' interaction with Zfp267 promoter regions. This interference promotes the accessibility of transcriptional machinery, facilitating Zfp267 gene expression. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor, indirectly stimulates Zfp267 by modulating the PI3K-Akt pathway. By inhibiting Akt activation, it influences downstream targets, including Zfp267, contributing to the overall regulation of cellular processes. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide, a sirtuin inhibitor, indirectly up-regulates Zfp267 by modulating the NAD+-dependent deacetylase activity. It influences the acetylation status of histones, indirectly affecting Zfp267 expression through epigenetic modifications. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A769662, an AMPK activator, indirectly stimulates Zfp267 by promoting AMPK signaling. By activating AMPK, it modulates downstream targets, influencing Zfp267 expression and contributing to the overall cellular regulation. | ||||||