SB 202190 CAS: 152121-30-7
MF: C20H14FN3O
MW: 331.34
An inhibitor of the isoforms p38α and p38β.

SB 202190 (CAS 152121-30-7)

SB 202190 | CAS 152121-30-7 is rated 5.0 out of 5 by 1.
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Alternate Names: 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
Application: SB 202190 is an inhibitor of the isoforms p38α and p38β
CAS Number: 152121-30-7
Purity: ≥98%
Molecular Weight: 331.34
Molecular Formula: C20H14FN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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SB 202190 is a pyridinyl imidazole that inhibits the p38 pathway. The compound inhibits the isoforms p38α and p38β. SB 202190 has displayed the ability to activate CPP32-like caspases and induce apoptosis. Research demonstrates that when one residue of ERK2, a related p38 not inhibited by pyridinyl imidazoles, is changed it allows SB 202190 to bind. Studies have revealed that SB 202190 can improve leukemia cell growth by activating MEK/MAPK, as well as phosphorylate and activate MLK3.


References

1. Jiang, Y., et al. 1996. J. Biol. Chem. 271: 17920-17926. PMID: 8663524
2. Nemoto, S., et al. 1998. J. Biol. Chem. 273: 16415-16420. PMID: 9632706
3. Fox, T., et al. 1998. Protein Sci. 7: 2249-2255. PMID: 9827991
4. Warrior, U., et al. 1999. J Biomol Screen. 4: 129-135. PMID: 10838421
5. Muniyappa, H. and Das, K.C. 2008. Cell. Signal. 20: 675-683. PMID: 18222647
6. Hirosawa, M., et al. 2009. Leuk. Res. 33: 693-699. PMID: 18995898

Physical State :
Solid
Solubility :
Soluble in DMSO (66 mg/ml at 25° C), methanol, DMF (~10 mg/ml), water (<1 mg/ml at 25° C), and ethanol (32 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
240-243° C
Boiling Point :
565.71° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
p38α: IC50 = 14.3 nM (human); p38 MAP kinase: IC50 = 30 nM; 5-LO: IC50 = 50 nM (human); p38 β: IC50 = 100 nM; Toxoplasma gondii: IC50 = 1 µM
Ki Data :
p38α: Ki= 5.01 nM (human); JNK3: Ki= 63.1 nM (human); JNK2: Ki= 0.25 µM (human); JNK1: Ki= 0.50 µM (human); ROR2: Ki= 0.79 µM (human)
pK Values :
pKa: 11.75 (Predicted), pKb: 9.37 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00941964
SMILES :
C1=CC(=O)C=CC1=C2NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

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Certificate of Analysis

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SB 202190 (CAS 152121-30-7)  Product Citations

See how others have used SB 202190 (CAS 152121-30-7). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 42 total

PMID: # 33686181  Amine, H.|Benomar, Y.|Taouis, M.| et al. 2021. Sci Rep. 11: 5427.

PMID: # 34187082  Fafián-Labora, JA.|O'Loghlen, A.| et al. 2021. Aging Cell. e13426.

PMID: # 33802847  Čermák, V.|Škarková, A.|Merta, L.|Kolomazníková, V.|Palušová, V.|Uldrijan, S.|Rösel, D.|Brábek, J.| et al. 2021. Biomolecules. 11:

PMID: # 33882688  Kothari, V.|Tang, J.|He, Y.|Kramer, F.|Kanter, JE.|Bornfeldt, KE.| et al. 2021. Arterioscler Thromb Vasc Biol. 41: 1854-1873.

PMID: # 34748616  Van Sciver, N.|Ohashi, M.|Nawandar, DM.|Pauly, NP.|Lee, D.|Makielski, KR.|Bristol, JA.|Tsao, SW.|Lambert, PF.|Johannsen, EC.|Kenney, SC.| et al. 2021. PLoS Pathog. 17: e1010045.

PMID: # 32035922  Grondona, P.|Bucher, P.|Schmitt, A.|Schönfeld, C.|Streibl, B.|Müller, A.|Essmann, F.|Liberatori, S.|Mohammed, S.|Hennig, A.|Kramer, D.|Schulze-Osthoff, K.|Hailfinger, S.| et al. 2020. J. Invest. Dermatol.

PMID: # 30731136  Höllerhage, M. et al. 2019. Neuropharmacology. 149: 13-26.

PMID: # 30422386  Gemperle, J.|Dibus, M.|Koudelková, L.|Rosel, D.|Brábek, J.| et al. 2019. Mol Oncol. 13: 264-289.

PMID: # 30365043  Dolivo, DM. et al. 2019. Int. J. Mol. Med. 43: 325-335.

PMID: # 30735839  Rahman, A.|Pallichankandy, S.|Thayyullathil, F.|Galadari, S.| et al. 2019. Free Radic. Biol. Med. 134: 527-544.

Citations 1 to 10 of 42 total
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Rated 5 out of 5 by from Mayr Mayr, M. et al. (PubMed 10660448) used SB 202190, an inhibitor of the p38 pathway, to study the effects of p38 MAPKs on stress induced apoptosis in vein grafts. Introduction of SB 202190 prevented stress induced apoptosis in vein grafts. -SCBT Publication Review
Date published: 2015-07-10
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