Molecular structure of Dorsomorphin dihydrochloride, CAS Number: 1219168-18-9
Dorsomorphin dihydrochloride (CAS 1219168-18-9)
See product citations (28)
Alternate Names:
Dorsomorphin dihydrochloride is also known as Compound C.
Application:
Dorsomorphin dihydrochloride is a potent, selective, reversible AMP-kinase inhibitor and BMP type I receptor inhibitor that can induce autophagy.
CAS Number:
1219168-18-9
Purity:
≥97%
Molecular Weight:
472.41
Molecular Formula:
C24H25N5O•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dorsomorphin dihydrochloride may act to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase Ki = 109 nM), induced by AICAR and metformin. Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein type 1 receptors (ALK2, ALK3, and ALK 6). Dorsomorphin dihydrochloride is not thought to show significant activity on structurally related kinases. Dorsomorphin dihydrochloride is also known as 6-[4-[2-(1-PIPERIDINYL)ETHOXY]PHENYL]-3-(4-PYRIDINYL)-PYRAZOLO[1,5-A]PYRIMIDINE DIHYDROCHLORIDE, Compound C, and bml-275.
Dorsomorphin dihydrochloride (CAS 1219168-18-9) References
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- Antioxidant enzymes mediate survival of breast cancer cells deprived of extracellular matrix. | Davison, CA., et al. 2013. Cancer Res. 73: 3704-15. PMID: 23771908
- An organizing role for the TGF-β signaling pathway in axes formation of the annelid Capitella teleta. | Lanza, AR. and Seaver, EC. 2018. Dev Biol. 435: 26-40. PMID: 29337130
- AMP-activated kinase is a regulator of fibroblast growth factor 23 production. | Glosse, P., et al. 2018. Kidney Int. 94: 491-501. PMID: 29861059
- Inhibitory role of AMP‑activated protein kinase in necroptosis of HCT116 colon cancer cells with p53 null mutation under nutrient starvation. | Le, DT., et al. 2019. Int J Oncol. 54: 702-712. PMID: 30431068
- Inhibition of proliferation and migration of melanoma cells by ketoconazole and Ganoderma immunomodulatory proteins. | Lu, CT., et al. 2019. Oncol Lett. 18: 891-897. PMID: 31289567
- Cyclocarya paliurus triterpenic acids fraction attenuates kidney injury via AMPK-mTOR-regulated autophagy pathway in diabetic rats. | Zhang, XX., et al. 2019. Phytomedicine. 64: 153060. PMID: 31401495
- L-Arginine alleviates heat stress-induced intestinal epithelial barrier damage by promoting expression of tight junction proteins via the AMPK pathway. | Xia, Z., et al. 2019. Mol Biol Rep. 46: 6435-6451. PMID: 31576512
- α1-Adrenergic receptors increase glucose oxidation under normal and ischemic conditions in adult mouse cardiomyocytes. | Papay, RS. and Perez, DM. 2021. J Recept Signal Transduct Res. 41: 138-144. PMID: 32757689
- Exogenous Hydrogen Sulfide Ameliorates Diabetic Myocardial Fibrosis by Inhibiting Cell Aging Through SIRT6/AMPK Autophagy. | Li, Y., et al. 2020. Front Pharmacol. 11: 1150. PMID: 32903815
- Urolithin A suppresses glucolipotoxicity-induced ER stress and TXNIP/NLRP3/IL-1β inflammation signal in pancreatic β cells by regulating AMPK and autophagy. | Zhang, Y., et al. 2021. Phytomedicine. 93: 153741. PMID: 34656886
- Arjunolic acid from Cyclocarya paliurus ameliorates diabetic retinopathy through AMPK/mTOR/HO-1 regulated autophagy pathway. | Zhang, XX., et al. 2022. J Ethnopharmacol. 284: 114772. PMID: 34688801
- Mechanisms and efficacy of metformin-mediated suppression of established experimental abdominal aortic aneurysms | Baohui Xu MD, PhD 1 ∗, Gang Li MD., PhD 1 2 ∗, Yankui Li MD., PhD 1, Hongping Deng MD., PhD 1, Anna Cabot BS 1, Jia Guo MD., PhD 1, Makoto Samura MD., PhD 1, Xiaoya Zheng MD., PhD 1, Tiffany Chen BS 1, Sihai Zhao MD., PhD 1, Naoki Fujimura MD., PhD 1, Ronald L. Dalman MD 1. 2023. JVS-Vascular Science.
Inhibitor of:
4931440F15Rik, ABHD5, ACTR-I, ADMP, AMPK, AMPKα2, AMPKγ1, Angptl5, Ataxin-10, BHLHA9, BMPR-IA, BMPR-IB, C16orf88, C1orf115, C3orf43, CCDC17, CLUAP1, DRP2, Exendin 4, FLYWCH1, follistatin, Glut12, Inhibin β-A, LGR6, LOC100041430, LOC100041450, LOC645941, LOC729855, LOC729928, Nanog, NK homeobox (NKX), Nkx-3.2, Olfr606, OTTMUSG00000011339, PERLD1, PGC-1α, RGMb, Sox-6, TBX18, TMEM64, TMEM74, WFDC10B, WFDC11, WFDC12, WFDC13, WFDC3, WFDC5, WFDC6, WFDC9, WWC3, and XKR6.Activator of:
ARK5, BC053393, BMP-5, BMP2, BMP4, BMPR-IB, C030046E11Rik, COL2A1, D3Ertd254e, D830030K20Rik, DEC2, DMRTA2, DOC4, EG433102, EG546638, EG623459, EG625591, ERBIN, Evx-1, GDF-11, GDF-3, gremlin-1, IDE, Lefty-1, Lefty-A, Lefty-B, LHX2, LHX4, LHX6, LMX1B, MINK1, NAA25, NOMO3, P23, PDC-E2, PYGL, Smad2, Smad6, Smad8, TFEB, TGF B-1, tinman, USP18, Vasorin, Zfp866, and ZNF512.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dorsomorphin dihydrochloride, 10 mg | sc-361173 | 10 mg | $186.00 | |||
Dorsomorphin dihydrochloride, 50 mg | sc-361173A | 50 mg | $751.00 |