CD137 Activators
CD137 activators are a diverse class of molecules that can indirectly lead to the activation of CD137. Despite the absence of direct binders, the activation of this protein can be achieved through the modulation of various cellular processes and signaling pathways. For instance, some activators like Phorbol 12-myristate 13-acetate (PMA) and Lipopolysaccharide (LPS) can activate CD137 through the induction of NF-κB, a transcription factor critical for immune responses.
Another method to activate CD137 is through the manipulation of intracellular calcium levels. Both Ionomycin and Cyclosporin A can influence calcium signaling, potentially leading to CD137 activation. Other activators like Forskolin and Anisomycin can influence CD137 activation through their effects on cyclic AMP levels and the JNK pathway, respectively. Additionally, some activators like MG-132 and Sodium Butyrate can indirectly lead to CD137 activation by altering protein degradation or gene expression patterns. Thus, the class of CD137 activators encompasses a wide range of molecules that can indirectly lead to CD137 activation through diverse mechanisms.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), which can lead to activation of NF-κB, a transcription factor that can induce CD137 expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore. It raises intracellular calcium levels, triggering signaling cascades that can activate CD137. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $117.00 $357.00 $928.00 | 17 | |
Concanavalin A is a plant lectin that binds to cell surface glycoproteins, triggering cellular activation and proliferation, and can lead to CD137 activation. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $96.00 $166.00 $459.00 $1615.00 | 12 | |
LPS is a major component of the outer membrane of Gram-negative bacteria. It can activate Toll-like receptors, leading to activation of NF-κB and subsequent CD137 activation. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an immunosuppressive drug that can inhibit calcineurin, preventing the dephosphorylation of NFAT, which can result in CD137 activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases, leading to increased phosphorylation and activation of various signaling molecules, potentially including pathways that activate CD137. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylate cyclase, increasing cyclic AMP levels and activating the PKA pathway, which can lead to CD137 activation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC. Through complex feedback mechanisms, it can lead to activation of alternative pathways that can activate CD137. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is an antibiotic and a potent activator of the JNK pathway, which can lead to MAPK pathway activation and CD137 activation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor. By preventing the degradation of IκB, it can lead to activation of NF-κB, which can activate CD137. | ||||||