Cytokeratin 5 Inhibitors
Common Cytokeratin 5 Inhibitors include, but are not limited to 1α,25-Dihydroxyvitamin D3 CAS 32222-06-3, Salinomycin CAS 53003-10-4, Itraconazole CAS 84625-61-6, Disulfiram CAS 97-77-8 and Lovastatin CAS 75330-75-5.
Cytokeratin 5, often abbreviated as CK5, belongs to the keratin family, which is a group of intermediate filament proteins that give structural stability to epithelial cells. Keratins are categorized into type I and type II, and Cytokeratin 5 is a type II keratin. It is primarily expressed in the basal layer of the epidermis and is pivotal in maintaining the structural integrity of epithelial tissues. Moreover, CK5 often pairs with its type I counterpart, Cytokeratin 14, to form the intermediate filament network in basal keratinocytes. This filamentous network serves as a scaffold, offering resilience against mechanical stress and ensuring cellular integrity. Additionally, CK5 expression patterns have been used in cellular and tissue-type identification due to its specific expression in certain epithelial cell types.
Cytokeratin 5 inhibitors encompass a range of molecules specifically designed to modulate, typically reduce, the expression or function of CK5. The primary mode of action of these inhibitors is to disrupt the synthesis or assembly of CK5-containing intermediate filaments. This can be achieved by directly interfering with the CK5 protein or by inhibiting pathways that regulate its expression or post-translational modifications. Since CK5 plays a key role in maintaining the structural rigidity of cells, its inhibition can lead to alterations in cellular architecture and mechanics. Furthermore, these inhibitors can also impact cellular interactions with their environment, as the keratin network interfaces with cell membranes, organelles, and other cytoskeletal elements. By targeting CK5, these inhibitors not only affect the individual cell's structural and mechanical properties but can also modulate the overall integrity and function of epithelial tissues where CK5 is prominently expressed. Understanding the nuances of these inhibitors can offer valuable insights into the complex world of epithelial cell biology and the intricate balance of structural proteins that maintain cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $162.00 $241.00 $406.00 $474.00 | 1 | |
Salinomycin targets epithelial-to-mesenchymal transition (EMT) markers. By inhibiting EMT, it may maintain epithelial cells in a state less conducive to CK5 expression. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Beyond its antifungal action, itraconazole impedes certain cellular pathways, potentially leading to a suppression of CK5 in epithelial cells. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram's modulation of epithelial markers might involve the suppression of basal epithelial markers, potentially leading to decreased CK5 levels. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin, besides its cholesterol-lowering effect, interferes with the mevalonate pathway, which might, in turn, suppress CK5 expression in specific cellular contexts. | ||||||
Bexarotene | 153559-49-0 | sc-217753 sc-217753A | 10 mg 100 mg | $55.00 $250.00 | 6 | |
As an RXR agonist, bexarotene promotes differentiation in certain cell types. This differentiation might shift the cellular profile away from a basal state, leading to reduced CK5 expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide induces DNA damage and can affect the expression of various proteins. Its effects might lead to reduced CK5 levels, particularly in cells that are sensitive to DNA damage. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone from soy, can modulate various signaling pathways. It may reduce CK5 expression by promoting epithelial cell differentiation or by directly affecting CK5 transcription. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
Fenretinide induces apoptosis and cellular differentiation. In pathways where CK5 is associated with a less differentiated state, fenretinide might lead to its down-regulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, can influence multiple signaling pathways. It may lead to reduced CK5 expression by modulating pathways that affect epithelial cell growth and differentiation. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and can affect the expression of various proteins. It might down-regulate CK5 due to its effects on cell cycle progression and cell survival. | ||||||