4-Hydroxyphenylretinamide CAS: 65646-68-6
MF: C26H33NO2
MW: 391.55
An agonist displaying activity at retinoid receptors.

4-Hydroxyphenylretinamide (CAS 65646-68-6)

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Synonym: Retinoic acid p-hydroxyanilide; Fenretinide; 4-HPR
Application: An agonist displaying activity at retinoid receptors
CAS Number: 65646-68-6
Molecular Weight: 391.55
Molecular Formula: C26H33NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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4-Hydroxyphenylretinamide (Fenretinide) is a synthetic retinoid analog of all trans retinoic acid, which displays antiproliferative effects on cultured human breast cancer cells. In addition, 4-Hydroxyphenylretinamide functions as a selective activator of RAR (retinoid receptors). Studies involving lymphoid and myeloid malignant cell lines indicate that 4-Hydroxyphenylretinamide can induce apoptosis and reduce cell growth. These studies suggest that 4-Hydroxyphenylretinamide and all trans retanoic acid may bind to two different receptors to induce apoptosis.


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Physical State :
Solubility :
Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml)), chloroform, and acetone (easily soluble).
Storage :
Store at -20° C
Refractive Index :
n20D 1.61
IC50 :
MDA-MB-231 (Breast adenocarcinoma cells): IC50 = 7700 (human); MCF7 (Breast carcinoma cells): IC50 = 150 (human); PC-3 (Prostate carcinoma cells): IC50 = 3600 (human); LNCaP (Prostate carcinoma): IC50 = 7500 (human)
Ki Data :
Retinoic acid receptor gamma: Ki= >400 nM (human); Retinoid X receptor alpha: Ki= >2200 nM (human); Retinoid X receptor beta: Ki= >2800 nM (human); Retinoid X receptor gamma: Ki= >6000 nM (human)
pK Values :
pKa: 9.98, pKb: 1.55
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 3998
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

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