Molecular structure of Itraconazole, CAS Number: 84625-61-6
Itraconazole (CAS 84625-61-6)
See product citations (23)
Alternate Names:
Oriconazole
Application:
Itraconazole is a triazole antifungal agent
CAS Number:
84625-61-6
Purity:
≥99%
Molecular Weight:
705.63
Molecular Formula:
C35H38Cl2N8O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Itraconazole is a chemical widely used in research for its antifungal properties, providing a model to study fungal growth inhibition in various environments. Researchers employ itraconazole to understand the mechanism of action of inhibitors of fungal cytochrome P450 enzymes, which are essential for the synthesis of ergosterol, a vital component of fungal cell membranes. In agricultural research, itraconazole is used to investigate fungal infections in crops and the potential for protecting plant health through antifungal applications. Studies involving biofilms, particularly those formed by Candida species, utilize itraconazole to explore biofilm prevention and disruption strategies. Environmental scientists also examine the degradation of itraconazole in water systems to assess its persistence and impact on aquatic organisms.
Itraconazole (CAS 84625-61-6) References
- Itraconazole in cyclodextrin solution. | Stevens, DA. 1999. Pharmacotherapy. 19: 603-11. PMID: 10331823
- Continuous itraconazole treatment for onychomycosis and dermatomycosis: an overview of safety. | Nolting, SK., et al. 1999. Eur J Dermatol. 9: 540-3. PMID: 10523732
- Itraconazole oral solution and intravenous formulations: a review of pharmacokinetics and pharmacodynamics. | Willems, L., et al. 2001. J Clin Pharm Ther. 26: 159-69. PMID: 11422598
- Role of itraconazole in haematology/oncology. | Pandya, NA., et al. 2003. Arch Dis Child. 88: 258-60. PMID: 12598396
- Itraconazole--perspectives for the management of invasive aspergillosis. | Groll, AH. 2002. Mycoses. 45 Suppl 3: 48-55. PMID: 12690972
- Itraconazole versus terbinafine in the management of onychomycosis: an overview. | Jain, S. and Sehgal, VN. 2003. J Dermatolog Treat. 14: 30-42. PMID: 12745853
- Itraconazole (Sporanox) in superficial and systemic fungal infections. | Caputo, R. 2003. Expert Rev Anti Infect Ther. 1: 531-42. PMID: 15482150
- Bioanalytical methods for the determination of itraconazole and hydroxyitraconazole: overview from clinical pharmacology, pharmacokinetic, pharmacodynamic and metabolism perspectives. | Yao, M. and Srinivas, NR. 2009. Biomed Chromatogr. 23: 677-91. PMID: 19309762
- [Level of evidence for therapeutic drug monitoring of itraconazole]. | Charles, M., et al. 2011. Therapie. 66: 103-8. PMID: 21635856
- Parameters that determine dissolution and efficacy of itraconazole and its relevance to recalcitrant dermatophytoses. | Sardana, K., et al. 2019. Expert Rev Clin Pharmacol. 12: 443-452. PMID: 30952196
- Itraconazole inhibits the Hedgehog signaling pathway thereby inducing autophagy-mediated apoptosis of colon cancer cells. | Deng, H., et al. 2020. Cell Death Dis. 11: 539. PMID: 32681018
- In vitro antiviral effects of GS-441524 and itraconazole combination against feline infectious peritonitis virus. | Doki, T., et al. 2022. Res Vet Sci. 144: 27-33. PMID: 35033848
- Repurposed itraconazole for use in the treatment of malignancies as a promising therapeutic strategy. | Li, CL., et al. 2022. Biomed Pharmacother. 154: 113616. PMID: 36055112
Inhibitor of:
ABCA, APCDD1L, ARFGAP, ARFGAP1, ARFGAP1/3, ARFGAP2, ARRDC4, ASCL1, Aspergillus, BBS5, Calcitriol, Candida albicans, CH25H, CHMP2, CHMP2B, CRABP-II, CRS1C-3, cryptdin 21, CYP20A1, CYP26, CYP26C1, CYP27A1, CYP27B1, CYP27C1, CYP2AB1, CYP2C18, Cyp2c38, Cyp2c39, Cyp2c50, Cyp2c67, Cyp2c70, CYP2D12, CYP2D40, CYP2G1, CYP2J13, CYP2J9, CYP2U1, CYP3A1, Cyp3a11, Cyp3a13, Cyp3a16, Cyp3a18, Cyp3a25, CYP3A4, Cyp3a41a, Cyp3a41b, Cyp3a44, CYP3A5, Cyp3a57, Cyp3a59, CYP46, CYP4A14, CYP4AA2, CYP4AA3, CYP4F22, CYP4F3, CYP4X1, CYP51A1, Cyp60, CYP8B1, cytochrome b5 type B, Cytokeratin 5, DAND5, DAZ Interacting Zinc Finger Proteins (DZIP), DCHS2, DISP2, DSCR 5, EG226604, ERG25, EXOSC (exosome component), EXOSC3, GLI-1, GLI-2, GRAMD1B, GUP1, HATH-1, HDRP, hedgehog, Hep B preS1, HH, HHAT, Hhip, HHIPL1, HHIPL2, hnRNP A1, HoxB5, HoxD13, HPV16 E5, Hrs-2, IFT80, INTU, IST1, KCTD7, KIAA0586, KIAA1822L, Laminin γ-2, LELP1, LMBR1, LOC730229, MACS1, MAMLD1, MESP2, NPC Marker, NSDHL, OATP-F, OATP-J, Olfr509, Olfr821, Olfr952, Olr239, Olr251, Olr403, patched, patched 2, PBR, Peroxin 5, PIG-O, PRAT4B_Cnpy4, PTCHD1, PTCHD2, PTCHD3, PTCHD4, PXR, Shh, Slco6c1, Slco6d1, Smo, STK36, Su(fu), Tect1, TMC6, TMEM215, TMEM231, TMEM37, TMEM97, TULP3, and V1RG12.Activator of:
CCDC65, Cyp3a41b, CYP51A1, DnaJB5, DZIP1, EVC2, OATP-J, smoothened, and ZNRF3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Itraconazole, 50 mg | sc-205724 | 50 mg | $76.00 | |||
Itraconazole, 100 mg | sc-205724A | 100 mg | $139.00 |