ZNF547 Activators
ZNF547 can influence its activity through various intracellular signaling pathways and modifications to the cellular environment. Forskolin raises intracellular cAMP levels, which activate protein kinase A (PKA). PKA then can phosphorylate proteins, including transcription factors, which may interact with ZNF547, leading to increased DNA binding and activation. Similarly, dibutyryl-cAMP, a cAMP analog, activates PKA, thereby potentially enhancing ZNF547 activation through similar phosphorylation events. In the case of PMA, it activates protein kinase C (PKC), which phosphorylates members of protein networks that include ZNF547, potentially increasing the protein's DNA binding activity. Ionomycin, by increasing intracellular calcium concentration, can activate calcium-dependent kinases capable of modifying ZNF547 or its associated proteins, thereby influencing its activity state.
Epidermal Growth Factor (EGF) and Insulin activate their respective receptors, triggering downstream signaling cascades such as the MAPK/ERK and PI3K/AKT pathways. These cascades can lead to the phosphorylation of proteins that either directly interact with ZNF547 or modify its regulatory environment, thus promoting its activity as a transcription factor. Histone deacetylase inhibitors, such as sodium butyrate and Trichostatin A, induce hyperacetylation of histones, resulting in a relaxed chromatin structure. This alteration in chromatin can facilitate ZNF547's access to its DNA binding sites, enhancing its transcriptional activation. Additionally, 5-Azacytidine reduces DNA methylation, which can also lead to increased ZNF547 activity by improving the protein's ability to access and bind to DNA. Compounds like resveratrol and spermidine affect the acetylation state of proteins and induce autophagy, respectively, creating a cellular context that supports ZNF547's activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which is involved in multiple signaling pathways. Activation of PKC has been known to phosphorylate proteins that could belong to the same network as ZNF547, thereby altering its conformation and enhancing its DNA binding activity or interaction with co-factors necessary for its functional activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Calcium is a secondary messenger that can activate calcium-dependent protein kinases, which could then modify the activity state of ZNF547 by phosphorylation or by influencing proteins that directly regulate ZNF547 function, leading to its activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid binds to retinoic acid receptors which can heterodimerize with other nuclear receptors. These complexes can interact with ZNF547, potentially co-activating transcription complexes where ZNF547 is bound to DNA, leading to an increase in ZNF547's transcriptional activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog which activates PKA. PKA then can phosphorylate proteins that are part of the same signaling pathways or complexes as ZNF547, leading to an increase in ZNF547's activation state and its ability to bind DNA and regulate gene expression. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the insulin receptor, setting off the PI3K/AKT pathway which can result in the phosphorylation of downstream proteins that may interact with ZNF547. This interaction could facilitate the recruitment of ZNF547 to its target genes, promoting its function as a transcription factor. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that leads to hyperacetylation of histones, causing chromatin relaxation. This change in chromatin structure can enhance the accessibility of ZNF547 to its target DNA sequences, thus potentiating its activation and function in gene regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, similar to sodium butyrate, is also a histone deacetylase inhibitor that can lead to a more open chromatin state, potentially facilitating ZNF547's binding to its target DNA sequences, and enhancing its transcriptional activation capability. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, leading to hypomethylation of DNA. This reduction in methylation can increase gene expression by allowing transcription factors like ZNF547 greater access to their target DNA sequences, thereby enhancing ZNF547's transcriptional activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to activate sirtuins, which are NAD+-dependent deacetylases. Activation of sirtuins can influence the acetylation state of histones or non-histone proteins that regulate the activity of transcription factors like ZNF547, potentially enhancing ZNF547's DNA binding and activation of transcription. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine has been associated with inducing autophagy and can modulate post-translational modifications. This can potentially influence the cellular environment in favor of ZNF547 activation, for instance, by inducing the degradation of inhibitory proteins or by promoting modifications that enhance ZNF547'sIt looks like you may have intended to ask for a table to be filled out with information on various compounds and how they could potentially affect the activity of a protein called ZNF547. Below is the information formatted as a Markdown table: | ||||||