Spermidine CAS: 124-20-9
MF: C7H19N3
MW: 145.25
A NOS1 inhibitor and NMDA and T4 polynucleotide kinase activator.

Spermidine (CAS 124-20-9)

Spermidine | CAS 124-20-9 is rated 4.5 out of 5 by 2.
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Alternate Names: N-(3-Aminopropyl)-1,4-diaminobutane
Application: Spermidine is a NOS1 inhibitor and NMDA and T4 polynucleotide kinase activator
CAS Number: 124-20-9
Purity: 99%
Molecular Weight: 145.25
Molecular Formula: C7H19N3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Spermidine inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). Spermidine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner.


References

1. Krug, M.S. and Berger, S.L. 1987. Meth. Enzymol. 152: 316- 325. PMID: 2443800
2. Cull, M., and McHenry, C.S. 1990. Meth. Enzymol. 182: 147-153. PMID: 2107372
3. Baumann, P., et al. 1997. Mutat. Res. 384: 65-72. PMID: 9298115
4. Hu, J., et al. 1994. Neurosci. Lett. 175: 41-45. PMID: 7526294
5. Tabor, C.W. and Tabor, H. 1984. Annu. Rev. Biochem. 53: 749-790. PMID: 6206782
6. Blethen, S.L., et al. 1968. J. Biol. Chem. 243: 1671-1677. PMID: 4870599
7. Bouché, J.P. 1981. Anal. Biochem. 115: 42-45. PMID: 6272602
8. Wu, W.H. and Morris, D.R. 1973. J. Biol. Chem. 248: 1687-1695. PMID: 4571773
9. Karkas, J.D., et al. 1975. J. Biol. Chem. 250: 8657-8663. PMID: 241752

Physical State :
Low-Melting Solid
Solubility :
Soluble in water (145 g/l) at 20° C, ethanol, and ether.
Storage :
Store at 4° C
Melting Point :
22-25° C
Boiling Point :
128-130° C at 14 mmHg
Density :
0.93 g/mL at 25° C
Refractive Index :
n20D 1.48 (lit.)
IC50 :
CHO: IC50 >100 µM (hamster); L1210: IC50 >100 µM (mouse); Calf thymus DNA: IC50 = 130 µM (bovine); HeLa: IC50 = 100 µM (human)
Ki Data :
Carbonic anhydrase II: Ki= 1.11 µM (human); Carbonic anhydrase VA: Ki= 1.22 µM (human); MDA-MB-231: Ki= 0.11 µM (human); Carbonic anhydrase IV: Ki= 0.11 µM (human); Carbonic anhydrase XIV: Ki= 1.00 µM (human)
pK Values :
pKb: 10.53 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
EJ7000000
PubChem CID :
1102
Merck Index :
14: 8742
MDL Number :
MFCD00008229
EC Number :
204-689-0
Beilstein Registry :
1698591
SMILES :
C(CCNCCCN)CN

Download SDS (MSDS)

Certificate of Analysis

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How long does it take to get spermidine delivered?

Asked by: christine03
Thank you for your question. Please contact our Customer Care Department to inquire about current product availability and shipping lead times to the Philippines. Please call us toll-free at (800) 457-3801 option 1, e-mail <[email protected]>, or use the live chat on our website.
Answered by: Technical Support
Date published: 2017-11-15

I received this product as a liquid and need to know its Molarity for experimental calculations. However, there is no mention of the total volume of this liquid to use for calculations. What is the Molarity of this when it arrives?

Asked by: Melissa234
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Rated 4 out of 5 by from Great features I am starting a new program and wish to test several new products for a different outcome.
Date published: 2019-06-11
Rated 5 out of 5 by from Wu et al Wu et al. (PubMed ID 4571773) showed spermidine inhibited biosynthetic arginine decarboxyalse feedback by blocking putrescine. -SCBT Publication Review
Date published: 2015-07-07
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