Date published: 2025-10-5

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Insulin Anticorpo () (CAS 11061-68-0)

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Fichas de dados

Veja citações de produtos (82)

Nomes alternativos:
Recombinant Human Insulin; rh-Insulin
Aplicacao:
Insulin é uma molécula produzida em E.coli
Numero VAT:
11061-68-0
Peso Molecular:
5807
Separar por Funcao:
C257H383N65O77S6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

LINKS RÁPIDOS

A insulina é uma hormona peptídica que desempenha um papel crucial no metabolismo, principalmente ao facilitar a absorção de glicose pelas células. Na investigação científica, a insulina é amplamente estudada pelos seus mecanismos de ação na captação celular de glicose e pelos seus efeitos metabólicos mais amplos. Especificamente, a insulina liga-se aos receptores de insulina na superfície celular, desencadeando uma cascata de eventos de sinalização intracelular. Esta via de sinalização envolve a ativação do substrato do recetor de insulina (IRS) e da fosfatidilinositol 3-quinase (PI3K), levando à translocação de vesículas do transportador de glucose tipo 4 (GLUT4) para a membrana celular, promovendo assim a captação de glucose. Para além dos seus papéis metabólicos clássicos, a insulina também influencia o crescimento e a diferenciação celular, uma área de investigação ativa. Foi demonstrado que a hormona ativa várias vias de sinalização, incluindo a via da proteína quinase activada por mitogénio Ras (MAPK), que influencia a expressão genética e a progressão do ciclo celular. Este duplo papel da insulina no metabolismo e na regulação celular constitui um modelo valioso para estudar a integração de sinais metabólicos e mitogénicos.


Insulin Anticorpo () (CAS 11061-68-0) Referencias

  1. A new approach to characterization of insulin derived from different species using 1H-NMR coupled with multivariate analysis.  |  Ohno, A., et al. 2012. Chem Pharm Bull (Tokyo). 60: 320-4. PMID: 22382411
  2. A highly selective and sensitive detection of insulin with chemiluminescence biosensor based on aptamer and oligonucleotide-AuNPs functionalized nanosilica @ graphene oxide aerogel.  |  Sun, Y., et al. 2019. Anal Chim Acta. 1089: 152-164. PMID: 31627812
  3. Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells.  |  Gu, L., et al. 2019. Int J Biol Sci. 15: 2815-2829. PMID: 31853220
  4. Excipient-free pulmonary insulin dry powder: Pharmacokinetic and pharmacodynamics profiles in rats.  |  Quarta, E., et al. 2020. J Control Release. 323: 412-420. PMID: 32325175
  5. Injectable Silk Fibroin-Based Hydrogel for Sustained Insulin Delivery in Diabetic Rats.  |  Maity, B., et al. 2020. ACS Appl Bio Mater. 3: 3544-3552. PMID: 35025224
  6. Special Thai Oolong Tea: Chemical Profile and In Vitro Antidiabetic Activities.  |  Rujanapun, N., et al. 2022. Front Pharmacol. 13: 797032. PMID: 35321328
  7. Comparative microelectrode array data of the functional development of hPsc-derived and rat neuronal networks.  |  Kapucu, FE., et al. 2022. Sci Data. 9: 120. PMID: 35354837
  8. An SPR-based method for Hill coefficient measurements: the case of insulin-degrading enzyme.  |  Distefano, A., et al. 2022. Anal Bioanal Chem. 414: 4793-4802. PMID: 35577931
  9. Formation of subvisible particles in commercial insulin formulations.  |  Silva-Jr, H., et al. 2022. Colloids Surf B Biointerfaces. 216: 112566. PMID: 35623256
  10. Increased disulfide peptide sequence coverage via "cleavage ON/OFF" switch during nanoelectrospray  |  Gongyu Li, et al. 2014. RSC Advances. 4.103: 59650-59654.

Informacoes sobre ordens

Nome do ProdutoNumero de CatalogoUNIDPrecoQdeFAVORITOS

Insulin, 100 mg

sc-29062
100 mg
$153.00

Insulin, 1 g

sc-29062A
1 g
$1224.00

Insulin, 10 g

sc-29062B
10 g
$12239.00

Does it work with rat skeletal L6 cells?

Asked by: AiChiF
Thank you for your question. We have not validated Insulin to work on rat skeletal L6 cells.
Answered by: BlakeJ
Date published: 2023-10-10

Is sc-29062, Insulin soluble in PBS? or water?

Asked by: Jz28sail
Thank you for your question. Getting recombinant insulin into solution isn't easy, and requires titration with HCl. It is recommended to reconstitute the lyophilized Insulin in sterile 0.005N HCl not more than 1 mg/ml. Our Human Insulin solution (sc-360248) works very well and has been recommended by the Chemicals Department as an alternative due to the difficulty of getting recombinant insulin into solution. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2018-04-02
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Rated 5 out of 5 by from OthmanOthman, et. al. (PubMed ID 24355212) used product sc-29062 in his study to describe the mechanism by which insulin can cause oxidative stress and serious downstream problems (start or support the progression of carcinogenesis in diabetic patients). -SCBT Publication Review
Date published: 2015-06-26
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Insulin Anticorpo () is rated 5.0 out of 5 by 1.
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