ZNF354C Activators
ZNF354C Activators encompass a suite of chemical compounds that indirectly bolster the functional activity of ZNF354C by targeting various biochemical pathways. Forskolin, through the elevation of cAMP levels, indirectly enhances ZNF354C function by activating protein kinase A (PKA), which subsequently phosphorylates transcription factors that could amplify the transcriptional activity of ZNF354C. Epigallocatechin gallate (EGCG) inhibits DNA methyltransferases, potentially decreasing methylation at the ZNF354C gene promoter and facilitating its transcription. Similarly, Sulforaphane activates the Nrf2 pathway, which may result in the transcription of genes containing antioxidant response elements that ZNF354C could be involved in regulating, thus enhancing its activity. Retinoic acid and Pioglitazone act upon nuclear receptors that can influence the transcription of ZNF354C by binding to specific response elements within its promoter.
Additionally, compounds like 5-Azacytidine and Trichostatin A modify the epigenetic landscape around ZNF354C, with the former reducing methylation and the latter increasing acetylation of histones, both conducive to ZNF354C transcription. Resveratrol activates SIRT1, influencing the deacetylation of transcription factors that govern ZNF354C expression. Curcumin modulates transcription factors and enzymes that control the epigenetic status of the ZNF354C promoter, while S-Adenosylmethionine provides methyl groups for histone methylation that could positively affect ZNF354C transcription. Sodium butyrate, as an HDAC inhibitor, facilitates a more open chromatin structure around ZNF354C, promoting its expression. Lastly, Dibutyryl-cAMP, a cAMP analog, activates PKA, potentially enhancing the transcriptional activity of ZNF354C through improved transcription factor binding to its promoter region.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases intracellular cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate transcription factors that enhance the transcriptional activity of ZNF354C. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) is a catechin found in tea, known to inhibit DNA methyltransferases. This inhibition can lead to hypomethylation of the ZNF354C gene promoter, potentially increasing ZNF354C expression and its functional activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, leading to the transcription of antioxidant response element (ARE)-driven genes. ZNF354C is believed to interact with Nrf2, enhancing its activity and promoting the expression of ARE-driven genes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, binds to retinoic acid receptors which can heterodimerize with retinoid X receptors and bind to retinoic acid response elements (RARE) in gene promoters, including potentially the ZNF354C promoter to enhance its expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, reducing methylation of gene promoters. The hypomethylation may lead to increased transcription of genes like ZNF354C that are subject to epigenetic regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylases (HDACs). By inhibiting HDACs, it causes hyperacetylation of histone proteins, which can result in a more relaxed chromatin structure and potentially enhanced transcription of ZNF354C. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to activate sirtuin 1 (SIRT1), which is involved in the deacetylation of transcription factors and histones. This activation may promote the deacetylation of factors that positively regulate ZNF354C transcription. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone is a PPAR-gamma agonist, which upon activation may influence the transcription of genes involved in glucose and lipid metabolism. It could enhance ZNF354C activity by affecting transcription factors that bind to the ZNF354C promoter region. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been reported to modulate various transcription factors and enzymes involved in epigenetic regulation. It could enhance the transcriptional activity of ZNF354C by affecting factors that interact with the ZNF354C gene promoter. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
S-Adenosylmethionine serves as a methyl donor in numerous methylation reactions, which can lead to the methylation of histones that positively influence transcription. This could include the methylation of histones around the ZNF354C gene, enhancing its expression. | ||||||