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Pioglitazone (CAS 111025-46-8)

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See product citations (13)

Application:
Pioglitazone is a PPAR agonist with potential antidiabetic characteristics
CAS Number:
111025-46-8
Purity:
≥98%
Molecular Weight:
356.44
Molecular Formula:
C19H20N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Pioglitazone, a thaizolidinedione derivative, may act to be a high affinity ligand for the peroxisome proliferator-activated receptor (PPAR), specifically PPARγ1 and PPARα activator. Binding assays have indicated that this activation is due to direct binding of pioglitazone to each subtype. It has been noted that this agent promotes adipocyte differentiation of mesenchymal and preadipocyte stem cell lines In vitro. Additionally, pioglitazone is an inhibitor of NF kappaB. It activates the peroxisome proliferator-activated receptor-gamma (PPAR-γ) receptor, a nuclear receptor involved in glucose metabolism.


Pioglitazone (CAS 111025-46-8) References

  1. Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.  |  Sakamoto, J., et al. 2000. Biochem Biophys Res Commun. 278: 704-11. PMID: 11095972
  2. Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease.  |  Breidert, T., et al. 2002. J Neurochem. 82: 615-24. PMID: 12153485
  3. Antiinflammatory and antiarteriosclerotic effects of pioglitazone.  |  Ishibashi, M., et al. 2002. Hypertension. 40: 687-93. PMID: 12411463
  4. Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo.  |  Saha, AK., et al. 2004. Biochem Biophys Res Commun. 314: 580-5. PMID: 14733947
  5. Reversal of glucose intolerance by by pioglitazone in high fat diet-fed rats.  |  Srinivasan, K., et al. 2004. Methods Find Exp Clin Pharmacol. 26: 327-33. PMID: 15319810
  6. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.  |  Heneka, MT., et al. 2005. Brain. 128: 1442-53. PMID: 15817521
  7. Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats.  |  Hunter, RL., et al. 2008. Neurosci Lett. 432: 198-201. PMID: 18207323
  8. Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats.  |  Ko, GJ., et al. 2008. Nephrol Dial Transplant. 23: 2750-60. PMID: 18388116
  9. Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats.  |  Sugiyama, Y., et al. 1990. Arzneimittelforschung. 40: 263-7. PMID: 2189419
  10. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).  |  Lehmann, JM., et al. 1995. J Biol Chem. 270: 12953-6. PMID: 7768881
  11. [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents.  |  Cantello, BC., et al. 1994. J Med Chem. 37: 3977-85. PMID: 7966158
  12. Disposition of the new antidiabetic agent pioglitazone in rats, dogs, and monkeys.  |  Maeshiba, Y., et al. 1997. Arzneimittelforschung. 47: 29-35. PMID: 9037440
  13. Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat.  |  Hallakou, S., et al. 1997. Diabetes. 46: 1393-9. PMID: 9287037

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Pioglitazone, 1 mg

sc-202289
1 mg
$55.00

Pioglitazone, 5 mg

sc-202289A
5 mg
$125.00