ZNF354C Inhibitors
Chemical inhibitors of ZNF354C act through various molecular mechanisms to inhibit the activity of this protein. Chelerythrine and Bisindolylmaleimide I target protein kinase C (PKC), a kinase responsible for the phosphorylation of many proteins, including ZNF354C. By inhibiting PKC, these compounds can prevent the phosphorylation of ZNF354C, which is a crucial post-translational modification necessary for its activity. Similarly, Genistein inhibits the activity of tyrosine kinases, enzymes that catalyze the transfer of a phosphate group from ATP to a tyrosine residue in a protein. Since ZNF354C activity is regulated by phosphorylation, Genistein's action can lead to decreased activity of ZNF354C by preventing this modification.
Furthermore, PD 98059 and U0126 work upstream of ZNF354C by inhibiting the mitogen-activated protein kinase (MAPK/ERK) and MEK1/2, respectively. These enzymes are part of a signaling cascade that is often necessary for the activation of various proteins, including ZNF354C. Inhibition of this pathway by PD 98059 and U0126 can reduce the activation state of ZNF354C. LY294002 and Wortmannin exert their effects by inhibiting phosphoinositide 3-kinases (PI3K), which are involved in many cellular functions, including the activation of proteins through phosphorylation. Staurosporine, a potent kinase inhibitor, can also diminish ZNF354C activity by inhibiting the kinase responsible for its activation. Lastly, PP2's selectivity for Src family tyrosine kinases can lead to the inhibition of ZNF354C. SP600125 and SB203580 target the JNK and p38 MAP kinase pathways, respectively, and by doing so, they can inhibit ZNF354C.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine is a potent inhibitor of protein kinase C (PKC). Since ZNF354C is a zinc finger protein that requires phosphorylation for its activity, inhibition of PKC by Chelerythrine leads to reduced phosphorylation and consequently the inhibition of ZNF354C activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. It inhibits the phosphorylation of proteins by tyrosine kinases. ZNF354C activity is regulated by phosphorylation, and thus Genistein can inhibit its function by preventing its phosphorylation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of mitogen-activated protein kinase (MAPK/ERK). ZNF354C may require ERK pathway activation for its function, hence PD 98059 would inhibit ZNF354C by hindering the pathway necessary for its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinases (PI3K) inhibitor. If ZNF354C requires PI3K signaling for its function, LY294002 would inhibit this protein by blocking the PI3K pathway. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. It can inhibit ZNF354C function by inhibiting the kinase that is responsible for the phosphorylation that activates ZNF354C. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. As ZNF354C's function can be dependent on the MAPK pathway, U0126 inhibits ZNF354C by preventing its activation through this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. By inhibiting PI3K, Wortmannin can lead to the inhibition of ZNF354C if PI3K signaling is required for ZNF354C's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). If ZNF354C operates downstream of JNK signaling, SP600125 would inhibit ZNF354C by blocking JNK activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. ZNF354C might be functionally dependent on p38 MAPK signaling, and SB203580 would inhibit ZNF354C by blocking this specific pathway. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). If ZNF354C function is calcium/calmodulin-dependent, KN-93 would inhibit this protein by blocking CaMKII. | ||||||