Date published: 2026-9-19

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KN-93 (CAS 139298-40-1)

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Alternate Names:
N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
Application:
KN-93 is an effective inhibitor of CaMKII phosphorylating activity
CAS Number:
139298-40-1
Purity:
≥95%
Molecular Weight:
501.04
Molecular Formula:
C26H29ClN2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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KN-93 is a synthetic compound that functions as a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). It is widely used in biochemical research to study the intracellular signaling pathways mediated by CaMKII, which plays a key role in various cellular processes, including synaptic plasticity, muscle contraction, and the regulation of gene expression. By inhibiting CaMKII activity, KN-93 helps researchers to delineate the enzyme′s contribution to calcium signaling events within neurons and cardiovascular tissues. This compound is particularly valuable in investigations related to learning and memory, as well as in contexts where CaMKII is implicated in maladaptive responses.


KN-93 (CAS 139298-40-1) References

  1. KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser.  |  Yue, C. and Sanborn, BM. 2001. Mol Cell Endocrinol. 175: 149-56. PMID: 11325525
  2. KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels.  |  Rezazadeh, S., et al. 2006. J Pharmacol Exp Ther. 317: 292-9. PMID: 16368898
  3. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells.  |  Sumi, M., et al. 1991. Biochem Biophys Res Commun. 181: 968-75. PMID: 1662507
  4. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro.  |  An, P., et al. 2007. World J Gastroenterol. 13: 1445-8. PMID: 17457979
  5. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer.  |  Rokhlin, OW., et al. 2010. Cancer Biol Ther. 9: 224-35. PMID: 20023417
  6. KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice.  |  Koga, T., et al. 2014. Autoimmunity. 47: 445-50. PMID: 24829059
  7. KN-93 inhibits IKr in mammalian cardiomyocytes.  |  Hegyi, B., et al. 2015. J Mol Cell Cardiol. 89: 173-6. PMID: 26463508
  8. Assessment of the protective effect of KN-93 drug in systemic epilepsy disorders induced by pilocarpine in male rat.  |  Ebrahimi, F., et al. 2019. J Cell Biochem. 120: 15906-15914. PMID: 31074121
  9. CaMKII inhibitor KN-93 impaired angiogenesis and aggravated cardiac remodelling and heart failure via inhibiting NOX2/mtROS/p-VEGFR2 and STAT3 pathways.  |  Ni, Y., et al. 2022. J Cell Mol Med. 26: 312-325. PMID: 34845819
  10. Calmodulin-dependent protein kinase II is required for G1/S progression in HeLa cells.  |  Rasmussen, G. and Rasmussen, C. 1995. Biochem Cell Biol. 73: 201-7. PMID: 7576494
  11. Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell.  |  Niki, I., et al. 1993. Biochem Biophys Res Commun. 191: 255-61. PMID: 8383489
  12. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase).  |  Tombes, RM., et al. 1995. Cell Growth Differ. 6: 1063-70. PMID: 8519682
  13. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.  |  Anderson, ME., et al. 1998. J Pharmacol Exp Ther. 287: 996-1006. PMID: 9864285

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

KN-93, 1 mg

sc-202199
1 mg
$182.00