Molecular structure of Ademetionine, CAS Number: 29908-03-0
Ademetionine (CAS 29908-03-0)
See product citations (2)
Alternate Names:
Ademetionine is also known as SAM-e.
Application:
Ademetionine is a common co-substrate involved in methyl group transfers to nucleic acids, proteins and lipids.
CAS Number:
29908-03-0
Purity:
≥98%
Molecular Weight:
398.44
Molecular Formula:
C15H22N6O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ademetionine is a common co-substrate involved in methyl group transfers to nucleic acids, proteins and lipids. It is produced from ATP in the liver and methionine, by action of the enzyme methionine adenosyltransferase. Ademetionine is an important intermediate in the biosynthesis of many molecules, including amino acids, hormones, and neurotransmitters. It is essential for the metabolism of sulfur-containing compounds and is involved in the methylation of DNA. Ademetionine may act to affect a variety of biochemical and physiological processes, including the regulation of gene expression, epigenetic modifications, and the modulation of cell proliferation, differentiation, and apoptosis. It also possesses anti-inflammatory, antioxidant, and anti-cancer effects.
Ademetionine (CAS 29908-03-0) References
- Efficacy of the dietary supplement S-adenosyl-L-methionine. | Fetrow, CW. and Avila, JR. 2001. Ann Pharmacother. 35: 1414-25. PMID: 11724095
- Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders. | Bottiglieri, T. 1997. Expert Opin Investig Drugs. 6: 417-26. PMID: 15989609
- [Influence of heptral on the functional-metabolic indices of the liver of rats with necrotizing pancreatitis]. | Sukach, MS. and Dolgikh, VT. 2013. Patol Fiziol Eksp Ter. 41-4. PMID: 24000713
- [Hepato- and endothelioprotective action of runihol and ademetionine in experimental liver injury induced by TB drugs in combination with alcohol]. | Sukhanov, DS., et al. 2013. Patol Fiziol Eksp Ter. 45-9. PMID: 24000714
- [Results of analysis of clinical effectiveness of cytoprotectors used in therapy of widespread forms of psoriasis]. | Grashin, RA., et al. 2014. Klin Med (Mosk). 92: 75-8. PMID: 25799835
- Effect of ademetionine on cytochrome P450 isoforms activity in rats. | Tong, S., et al. 2015. Int J Clin Exp Med. 8: 9716-22. PMID: 26309647
- Open-label study of ademetionine for the treatment of intrahepatic cholestasis associated with alcoholic liver disease. | Ivashkin, VT., et al. 2018. Minerva Gastroenterol Dietol. 64: 208-219. PMID: 29431335
- Reproductive toxicity studies of ademetionine. | Cozens, DD., et al. 1988. Arzneimittelforschung. 38: 1625-9. PMID: 3214447
- Lack of mutagenic activity of ademetionine in vitro and in vivo. | Pezzoli, C., et al. 1987. Arzneimittelforschung. 37: 826-9. PMID: 3314881
- [Mixed steatohepatitis: more questions than answers (part 2)]. | Raikhelson, KL., et al. 2021. Ter Arkh. 93: 516-520. PMID: 36286790
- Use and misuse of antidepressant drugs in a random sample of the population of Rome, Italy. | Arpino, C., et al. 1995. Acta Psychiatr Scand. 92: 7-9. PMID: 7572252
- [A meta-analysis of therapeutic trials with ademetionine in the treatment of intrahepatic cholestasis]. | Frezza, M. 1993. Ann Ital Med Int. 8 Suppl: 48S-51S. PMID: 8117521
Inhibitor of:
AdoMetDC, Apobec-1, B630005N14Rik, BAHD1, BC003883, FTSJ1, JMJD1A, Khdc1b, KRTAP1, LOC283143, LOC440900, LOC644248, MAT IIβ, MBD3L5, METT11D1, METTL25, METTL9, MRGBP, PCDHGA6, PCMTD1, PRAMEF14, Protamine 3, RG9MTD1, TDRD1, TRM11, TRM12, TRMT5, vanin-2, YT521-B, YTHDC2, YTHDF2, and ZMYM3.Activator of:
γ-GCSm, 1110037F02Rik, 1300003B13Rik, 1700106N22Rik, 2310079F23Rik, 2810422O20Rik, 4732471D19Rik, 4832428D23Rik, 5-Methylcytidine, 5830415F09Rik, 7530422B04Rik, 8-oxoG DNA Lesion, 8D6, ADAT1, ADAT2, ADAT3, ADCK4, ADH, AGAT, AGXT2L1, AHCYL2, AHDC1, AKR1CL1, ALDH1L1, ALDH1L2, ALDH5A1, ALG12, ALKBH3, Amd2, AMT, ANKRD13D, Antiquitin, Apobec-1, APRT, ARD, ARID3B, ASMT, ASMTL, Asparagine synthetase, ASXL3, AUH, B630005N14Rik, BAZ2A, BBOX1, BC023814, BHMT, BHMT2, biotinidase, BTEB2, C14orf138, C1orf113, C2orf34, C3orf30, C5orf35, C7orf73, C8orf79_6430573F11Rik, Carbonyl reductase 3, CBS, CBX7, CCDC21, CD77 synthase (A4GALT), CDO1, CEPT1, CGBP, CHDH, choactase, ChoKB, CHPT1, Chr-B, COMTD1, CPN cat, CPOX, CPSF, CSAD, cSHMT, CTH, CTU1, CWC22, CYP27C1, CysRS, cyt19, DDA3, DDAH I, DHDPSL, DHRS12, Dim1, DMGDH, DNA pol δ cat, Dnmt1, Dnmt2, Dnmt3L, DOT1, DOT1L1, DPF3, DPH2, DPY-30, E(z), EAAT1, EBLN2, Edc4, EEPD1, EG436008, EG628456, EHMT1, Elongin A3, ELP4, Epigen, ERI-1, ESD, Eso-1, exonucleasefamily surface anchored protein, F8A2, F930017I19Rik, FAM175B, FAM183A, FAM208A, FAM22A, FAM44A, FBP21, FEN-1, Fibrillarin-like 1, FIC1, FLJ23356, Folic Acid, Formate Dehydrogenase, FTSJ2, FTSJ3, FUT2, GAGE7B, GalNAc-T2, GAMT, Gatm, GCAT, GCL, GDC, GGCT, GGL, GlcAT-S, Glutathione, GLYATL2, Glyoxalase II, Gm628, Gm71, GMPR1, GNMT, GON4L, GPx-6, GSH-1, GSS, GSTT3, H2afb2, Headpin, HEATR5B, HEMK2, Hep B preS1, Hep C NS5a, Hint3, HISPPD2A, Histone cluster 1 H1C, Histone cluster 1 H1D, Histone cluster 1 H1E, Histone cluster 1 H2AL, Histone cluster 1 H2BA, Histone cluster 1 H2BE, Histone cluster 1 H2BG, Histone cluster 1 H3D, Histone cluster 1 H3G, Histone cluster 1 H4I, Histone cluster 2 H2AA3, Histone cluster 2 H3A, Histone cluster 3 H2A, Histone cluster 3 H2BB, HLCS, HMG-4, HMG20A, hMLH3, HNMT, HORMAD2, HP1γ, HPRG, HSCARG_NMRAL1, HSPC038, HSV-1 ICP27, HTF9C, HTR3E, ICMT, JMJD3, JMJD5, JMJD7-PLA2G4B, KAT II, Khdc1b, KIAA1024_AF529169, KIAA1429, kismet, kismet-L, KMT5A (Lysine Methyltransferase), L2HGDH, L3MBTL, LBXCOR1, LEO1, LIN-53, LMBRD1, LOC100040923, LOC100041179, LOC100041231, LOC100041407, LOC441461, LOC729454, LTrp7, MafB, MAGE-H1, MAT I, MAT Iα, MAT IIα, MAT III, MBD2, MBD3L2, MBD6, MBTD1, METT10D, METT11D1, METTL1, METTL10, METTL11A, METTL11B, METTL2, METTL23, METTL25, METTL2A, METTL2B, METTL3, METTL4, METTL5, METTL6, METTL8, METTL9, MFT, MGC42105, MGC50559_4833442J19Rik, MGC52110, MLL3, MLL5, MMAA, MMADHC, MPST, MRI1, MRP-L42, MRP-L48, MRP-L53, mSHMT, MSR, mt-Atp8, MTGR1, MTHFD2L, MTHFSD, MTO1, MTR, MTRR, MYSM1, N6AMT2, NAP1L2, NAP1L5, NAT-14, Nebulin, NELF, neuroglobin, NNMT, NOC3L, NSUN1, NSUN2, NSUN3, NSUN5, NSUN5B, NSUN5C, NSUN7, NT5DC1, NUDT8, OAZIN, Olfr15, Olfr870, OR11L1, OSAP, OTP, OTTMUSG00000018481, PCGF1, PCIF1, PCMTD1, PCMTD2, Peg12, PEMT, PHC1, PHC3, PHF12, PHF16, PHF20L1, PIG-N, PIMT, PIWI, PME-1, POGZ, POLR2J3, POTE8, PPC Synthetase, PRDM9, PRMT1, PRMT10, PRMT2, PRMT3, PRMT6, PRMT7, PRMT8, PSS1, PSS2, PSTK, Punc, PUS1, PUS4_TRUB1, PUS7, putrescine extracellular binding protein, R3HDM2, RG9MTD2, RGD1564058, RIMKLB, RING1B, RIZ, RMND1, RNMT, RPUSD3, RPUSD4, SAP 130, SAP 62, sarcosine dehydrogenase, Sbp, Sbpl, SCAND1, SDS3, SEPHS2, Set1A, SET7/9, SETD4, SETD5, SGS3, Siglec-E, SLC6A15, Sm B/B′, SMYD1, SMYD2, SMYD4, SNURF, Sox-22, SPANX-N5, SPDSY, Spi13, SPT3, SSAT, St3Gal-II, STK33, SUV39H1, TAF I p48, TAF II p130, TAF II p70, TAF9B, TDG, TDRD5, TDRD9, THNSL2, TMEM14A, TNRC6B, Tomt, TPH, TPH2, TRBP2, TRM12, TRMT1, TRMT112, Trmt2b, TRMT5, TRMT6, TRMT61B, TRUB2, TTLL6, TYW1, TYW1B, TYW4, UBE2G2, Ubie3, UGT1A2, UHRF1, v-Maf, vanin-3, Vgl-1, WBP5, WBSCR27, WDR33, XRN2, Ythdc1, ZC3H13, ZCCHC6, ZCWPW1, ZFP1, ZIM3, ZMAT1, ZNF213, ZNF229, ZNF232, ZNF329, ZNF354C, ZNF385C, ZNF410, ZNF500, ZNF525, ZNF577, ZNF594, ZNF646, ZNF678, ZNF729, ZNF75A, ZNF766, ZNF778, ZNF814, ZNF839, ZSCAN23, and ZUFSP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ademetionine, 100 mg | sc-278677 | 100 mg | $180.00 | |||
Ademetionine, 1 g | sc-278677A | 1 g | $655.00 |