ZFAT Activators
ZFAT Activators constitute a diverse class of compounds that influence various cellular signaling pathways, ultimately leading to the functional enhancement of ZFAT, a transcriptional regulator. Forskolin, by increasing intracellular cAMP levels, activates PKA, which in turn can phosphorylate and activate transcription factors that work in concert with ZFAT to regulate gene expression. This mechanism is shared by isoproterenol and exogenous cAMP. PMA and prostratin, through their activation of PKC, modulate T-cell receptor signaling pathways, which can enhance ZFAT's activity in immune response regulation. Similarly, ionomycin and A23187, by increasing intracellular calcium levels, activate pathways involving calcineurin and NFAT, both of which are crucial to T-cell activation and may promote ZFAT's transcriptional activity.
Additionally, BAY 11-7082's inhibition of NF-κB signaling could indirectly result in the upregulation of ZFAT activity as part of a compensatory mechanism in immune cells. Sphingosine-1-phosphate (S1P) engages with its receptors to modulate survival and proliferation signals, potentially affecting ZFAT activity due to its role in transcriptional regulation. Okadaic acid and anisomycin influence protein phosphorylation states and stress-activated pathways, respectively, which could potentially enhance ZFAT's regulatory functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin acts on adenylate cyclase, increasing intracellular cAMP levels which in turn activate PKA. This cascade can result in the phosphorylation of transcription factors and the subsequent enhancement of ZFAT's regulatory functions in gene expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA mimics diacylglycerol (DAG) and activates PKC, which plays a role in T-cell activation pathways. Enhanced PKC activity can upregulate signaling pathways in which ZFAT is a critical transcriptional player, leading to its increased activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin raises intracellular calcium levels, activating calcineurin and NFAT, which are part of the signaling pathways regulating T-cell activation. This action can synergistically enhance the transcriptional activity of ZFAT in immune cells. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, by binding to beta-adrenergic receptors, increases cAMP synthesis, indirectly promoting the activation of ZFAT through PKA-mediated signaling pathways involved in transcriptional regulation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 elevates intracellular calcium levels, similar to ionomycin, potentially amplifying signaling pathways that lead to ZFAT activation, specifically within the context of T-cell and B-cell immune responses. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits IκBα phosphorylation, thereby modulating NF-κB activity. This modulation can lead to compensatory transcriptional activities where ZFAT may be upregulated to maintain immunological balance. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $138.00 $530.00 | 24 | |
Prostratin activates PKC, which could enhance the transcriptional regulation activity of ZFAT within T-cell signaling pathways by modulating the activity of downstream transcription factors. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P binds to its receptors, initiating signaling that can influence transcriptional events. ZFAT, as a transcriptional regulator, may have its activity enhanced by such S1P receptor-mediated signaling. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
cAMP, as a secondary messenger, can activate PKA and modulate transcriptional regulation, potentially enhancing the functional activity of ZFAT in its role as a transcriptional regulator. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits phosphatases, leading to heightened phosphorylation within signaling pathways that can indirectly enhance ZFAT's transcriptional regulatory functions. | ||||||