Molecular structure of Adenosine 3′,5′-cyclic monophosphate, CAS Number: 60-92-4
Adenosine 3′,5′-cyclic monophosphate (CAS 60-92-4)
Alternate Names:
cyclic AMP; cAMP
Application:
Adenosine 3′,5′-cyclic monophosphate is a second messenger and key intracellular regulator
CAS Number:
60-92-4
Molecular Weight:
329.21
Molecular Formula:
C10H12N5O6P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Adenosine 3′,5′-cyclic monophosphate (cAMP) is an important second messenger and intracellular regulator in many biological processes and, in particular, is used in intracellular signal transduction to convey the cAMP-dependent pathway. Adenosine 3′,5′-cyclic monophosphate is derived from ATP and is an adenine nucleotide containing one phosphate group which is esterified to both the 3′- and 5′-positions of the sugar moiety. In eukaryotic cells, Adenosine 3′,5′-cyclic monophosphate function in many biochemical processes, including the regulation of glycogen, lipid and sugar metabolism. In these roles, Adenosine 3′,5′-cyclic monophosphate works by activating PKA (protein kinase A). Additionally, Adenosine 3′,5′-cyclic monophosphate works independently of PKA in activating calcium channels and proving a pathway for the release of growth hormone.
Adenosine 3′,5′-cyclic monophosphate (CAS 60-92-4) References
- Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system: effects of dibutyryl adenosine 3',5'-cyclic monophosphate, alpha-glycyrrhetinic acid, and cytosine arabinoside. | Robe, PA., et al. 2000. Biochem Pharmacol. 60: 241-9. PMID: 10825469
- Attenuation of the development of morphine dependence/tolerance by nefiracetam: involvement of adenosine 3':5'-cyclic monophosphate system. | Itoh, A., et al. 2000. Behav Brain Res. 115: 65-74. PMID: 10996409
- Measurement of adenosine 3',5'-cyclic monophosphate and guanosine 3', 5'-cyclic monophosphate in mussel (Mytilus galloprovincialis lmk.) by high-performance liquid chromatography with diode array detection. | Díaz Enrich, MJ., et al. 2000. Anal Biochem. 285: 105-12. PMID: 10998269
- Inhibition of stimulated Jurkat cell adenosine 3',5'-cyclic monophosphate synthesis by the immunomodulatory compound HR325. | Curnock, AP., et al. 2001. Biochem Pharmacol. 61: 227-35. PMID: 11163337
- Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A. | Staples, KJ., et al. 2001. J Immunol. 167: 2074-80. PMID: 11489990
- Acute ethanol inhibits extracellular signal-regulated kinase, protein kinase B, and adenosine 3':5'-cyclic monophosphate response element binding protein activity in an age- and brain region-specific manner. | Chandler, LJ. and Sutton, G. 2005. Alcohol Clin Exp Res. 29: 672-82. PMID: 15834234
- Clomiphene citrate inhibits gonadotropin-induced ovulation by reducing cyclic adenosine 3',5'-cyclic monophosphate and prostaglandin E2 levels in rat ovary. | Chaube, SK., et al. 2006. Fertil Steril. 86: 1106-11. PMID: 16962119
- Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3',5'-cyclic monophosphate. | Masyuk, TV., et al. 2007. Gastroenterology. 132: 1104-16. PMID: 17383431
- T cell adhesion primes antigen receptor-induced calcium responses through a transient rise in adenosine 3',5'-cyclic monophosphate. | Conche, C., et al. 2009. Immunity. 30: 33-43. PMID: 19144315
- cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. | Taylor, SS., et al. 1990. Annu Rev Biochem. 59: 971-1005. PMID: 2165385
- Fundamental reaction pathway and free energy profile for hydrolysis of intracellular second messenger adenosine 3',5'-cyclic monophosphate (cAMP) catalyzed by phosphodiesterase-4. | Chen, X., et al. 2011. J Phys Chem B. 115: 12208-19. PMID: 21973014
- STAT1, STAT6 and adenosine 3',5'-cyclic monophosphate (cAMP) signaling drive SOCS3 expression in inactive ulcerative colitis. | Li, Y., et al. 2012. Mol Med. 18: 1412-9. PMID: 23154639
- Cyclic AMP and calcium in the transduction of hypothalamic neurohormone action in human pituitary tumors. | Spada, A., et al. 1997. Horm Res. 47: 235-9. PMID: 9167957
- Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. | Chen, TC., et al. 1998. Lab Invest. 78: 165-74. PMID: 9484714
- Cyclic AMP signaling and gene regulation. | Daniel, PB., et al. 1998. Annu Rev Nutr. 18: 353-83. PMID: 9706229
Inhibitor of:
5430421N21Rik, A26C1B, A630023A22Rik, AA416372, AB056442, AGAP3, AKAP 1, Bbip1, BRF2, Gm4841, Olfr1031, Olfr111, Olfr356, Olr480, Olr601, Olr610, Olr611, Olr614, Olr619, Olr634, Olr636, PAC4, SCHIP1, SCO-spondin, TIG3, and ZNF541.Activator of:
α-2M, α-internexin, β2-chimaerin, β3Gn-T1, β3Gn-T3, γ1-Syntrophin, 0610008F07Rik, 11β-HSD1L, 1110008J03Rik, 1300017J02Rik, 1500016O10Rik, 17β-HSD6, 1700001F09Rik, 1700009P17Rik, 1700010L13Rik, 1700012B09Rik, 1700015E13Rik, 1700016D02Rik, 1700016G22Rik, 1700019O17Rik, 1700023C21Rik, 1700027N10Rik, 1700052N19Rik, 1700057G04Rik, 1810008A18Rik, 1810030J14Rik, 2010007H12Rik, 2010309E21Rik, 2310022A10Rik, 2310066E14Rik, 2410131K14Rik, 2610020H08Rik, 2610044O15Rik, 2700062C07Rik, 2810004N23Rik, 2810022L02Rik, 3β-hsd1, 3β-HSD2, 5830404H04Rik, 6330416L07Rik, 6330569M22Rik, 6430531B16Rik, 8430426H19Rik, AB056442, ABBA-1, ABC1, ABCA16, ACAA1, ACCα, ADX, Agrin, AI324046, AKAP 10, AKAP 100, AKAP 149_AKAP 121, AMAP-1, AMIGO1, AMIGO3, AMN1, ANKS4B, Annexin IV, Annexin XI, ANXA2R, ANXA8L1, AP1S2, apterous, ARL5A, Arylsulfatase D, Arylsulfatase K, ASTE1, ATP11A, ATP1AL1, ATP5 (Complex V; Mitochondrial ATP synthase), ATP8A1, ATP8B3, AWAT1, Axonin-1, BAIAP2L2, BBP, BC002199, BC038925, Bhlhb9, BM88, Bordetella pertussis toxin, brevican, BRINP2, BSPH1, BUP-1, c-Erb-A β-1, C-MIP, C/EBP ε, C030048B08Rik, C14orf138, C16orf52, C16orf88, C17orf50, C19orf69, C20orf3, C20orf77, C3, C3orf38_4930453N24Rik, C3orf59, C5orf29, C6orf35, C85492, C8orf31, C9orf79, CaBP1, CaBP3, CABYR, cadherin-28, calmin, CaMKIV, CAMSAP1L1, Carcinoma marker, CASPR, CASPR3, CCDC127, CCDC19, CCDC22, CCDC28B, CCDC32, CCDC63, CCDC72, CD32-C, CD39L1, CD3EAP, CDK2AP2, CDS1, CEL, Cerebellin 2, choactase, CHRAC17, CLCN5 (CLC-5), CLIC4, CLN5, CMV US28, CNG-β3, CNG-1β, CNG-2, CNG-4, Cngb1, CNTFRα, Complexin-4, connexin 36, connexin 40, Connexin 43, Corin, CPE, CPEB3, CPN cat, CRIPT, Cripto-3, CRMP-5, CRP3, CSHL1, CT45-2, CXorf34, CYB5D2, cyclin A-type, Cylicin-2, CYP11B, Cytokeratin 6E, D930020E02Rik, DANGER, DAZ1, DCAMKL1, DDEF2, DEXI, DGK-δ, DNA pol γ, DNAH12, DNB5, DOCK 7, DPF3, Draxin, DSEL, DUXA, EDA, EF-CBP2, EG384813, EG432838, EG626305, EG635895, EG666713, ELOVL4, EPCR, EphA7, Eppin, Eps8L1, ER81, Ermin, ESM-1, ExoC3L, exonucleasefamily surface anchored protein, EY-cadherin, FAM115A, FAM12, FAM120B, FAM150B, FAM21C, FAM25, FAM26F, FAM83F, Fascin 3, FEM-2, FHR-1, Filamin 3, FKBP15, FMVB12B, foocen, FOXB1, FOXD3, FOXR1, Fra-2, FRMD4A, FRMPD4, FSHα, G β1, G6Pase-α, Galanin, galectin-4, GalNAc-TL5, GalNAc4S-6ST, GANC, gasdermin C, GBP2, GC kinase, GC-1, GC-A, GIT1, Gliomedin, Glucagon Receptor, Glutamate-Oxaloacetate Transaminase, Gm1966, GM2-AP, Gm221, Gm239, Gm266, Gm428, Gm766, Gm97, Gm98, GnT-III, Gpa2, GPR33, GPR89B, Gram Positive Bacteria Marker, GRK 7, group XIIB sPLA2, GTF2IRD2, H2-Eκ, H2-M10.6, Harmonin, HBO1, hCG_15200, Headpin, HEATR5A, HEC-GlcNAc6ST, HESL, Hils1, Histone cluster 1 H4, Histone cluster 4 H4, HIVEP3, HOM-TES-103, Homer-2, Hop, HoxA6, HTF9, hyccin, HYDIN, ICAM-4, ICAP-1, Ichthyin, IGSF4B, IGSF9, Ik1, IL-29, IL-7R, INPP5B, INSL3, Integrin β2, Intersectin, JFC1, Junctophilin-2, KCNMB2, KCTD6, KIAA0922_mKIAA0922, KIAA0953, KIDINS220, Krtap28-10, KRTAP5-9, KV1.2, KV4.2, LAL, Laminin γ-3, Laminin-R, Latrophilin-2, Lce1a2, LEMD1, LENG8, LGI2, LGI4, LHFPL4, LIMP II, LIPI, Liprin α3, Liprin α4, LLGL4, LOC100039934, LOC100040962, LOC100041324, LOC283143, LOC390956, LOC646851, LOC728200, LOC729005, LOC730094, LPD lipase, LRFN2, LRRC67, LRSAM1, Lutropin β, LUZP2, Ly-6C2, LYPD1, MAMDC4, MAP-2B, MAP-2C, MBP-probe, Mcsp, MCT1, MFSD1, MFSD2B, MILI, MMP-12, MOBKL2C, MoCo Sulfurase, MOR-1, MPPED2, MRAP, MS4A8B, MST-3, MTMR9, Mucin 19, Mucin 8, MUP1, MUP10, MUP13, MUP14, MUP17, MuRF1, MYL7, NAG7, NAGPA, NALP9C, NAT-3, NBC4, NBPF1, NBPF16, NBPF24, NBPF7, NC2α, NCAM-L1, Ncapd3, NCC, Nectin 3, netrin-4, neuroguidin, Neuronatin, NF45, NHERF-1, NHLRC4, NIPA, Nir1, Nir3, NKCC2, nm23-H3, NOBOX, Nogo-R, NPAL1, NPB, NPSF, NRAGE, nucleobindin 2, OAT1, OATP2A1, Oatp4, Obox3, OCIAD1, OCM, Oct-6, OLFM2, Olfr1095, Olfr1100, Olfr467, Olfr469, Olfr477, Olfr478, Olfr479, Olfr506, Olfr507, Olfr885, Olfr887, Olfr9, Olfr902, Olfr904, Olfr905, Olfr906, Olfr907, Olfr908, Olfr909, Olfr91, Olfr910, Olfr912, Olfr936, Olfr967, OPAL1, OPN1SW, OR1L3, OR2G3, OR2M2, OR2T27, OR2T3, OR2T33, OR2T5, OR2W3, OR4C46, OR4F16, OR5AC2, OR5B12, OR5I1, OR5K3, OR5K4, OR7G3, OR9G4, Otolin-1, OTTMUSG00000002040, OTTMUSG00000002042, OTTMUSG00000002043, OTTMUSG00000002045, OTTMUSG00000011268, OTTMUSG00000012557, OTTMUSG00000012817, OTTMUSG00000017864, OTTMUSG00000018964, OTTMUSG00000018981, OTTMUSG00000018984, OTTMUSG00000018988, OTTMUSG00000018998, OTTMUSG00000019001, OTTMUSG00000019010, OTTMUSG00000019138, OVOL3, PACSIN3, PAI-2, Paralemmin, Pax-8, PCAN1, PCDHA10, PCDHA3, PCDHAC1_Pcdhac1, PCDHB16, PCDHGA8, PCDHGB1, PCDHGB5, PCDHGC, PCID2, PCMT1, PCYOX1, PDZK7, PE, Pelle, PEPCK-C, PEPCK-M, Perilipin, PHF15, Pho85, Phosphogluco-mutase, PHRF1, piccolo, PKA, PLA1A, PLA2R, Placental lactogen, Placental lactogen Iα, Placental lactogen II, PLB, Plb1, PLET1, Plk5, PLSCR1, PMCA4, PMF-1, PNGase, PNS Myelin, Polycystin-1, Polycystin-2, POP5, Popeye 3, PP2A-B56-γ, PPP1R12C, Presenilin 1, PRHOXNB, probasin, proenkephalin A, Psg29, PSG8, PspA, PTH/PTHrP-R, PTPλ, Ptpn23, Pumilio 2, PUS1, PYGB, QDPR, Rab 4B, Raftlin, RBA-2, RCK, Reg Iα, RGAG1, RHBDL1, Rho GAP, Rhox2f, Rhox2g, Rhox2h, Rhox6, RIMKLB, RNF223, robo3, rotatin, Rpp14, RSHL3, Rsk-2, RUSC2, S-Myc, SAA1, Sall1, SAP 97, SBK2, SCP-1, Sec5, Semenogelin-1, Sfta2, SGLT-1, SH-PTP1, SH3BGRL3, SH3TC2, Sialyltransferase 10, SLC22A15, SLC25A46, SLC26A9, SLC35F4, Slit1, SMEK1, Smok2b, SNED1, Snrp116, SNX1, SNX7, Sox-14, SP-A2, Sp3, spectrin α, spectrin β I, Sphingomyelin Synthase 1, Sphingomyelin Synthase 2, Sprr2h, Sprr2i, SPT3, SR-7, SRGAP2P1, SRPX2, SRRM4, SSTK-IP, SSX2, StAR, Ste2, STEP, SULT1E1, SULT2A3, SULT2A6, Supervillin, Sval2, Sval3, Svs4, Svs5, Svs6, Synaptogyrin-2, syncytin-B, T-kininogen 2, TAF II p250, TAFA1, TBCD, Tctex5, TEF-1, Tenascin-R, Teneurin-1, TEPP, TFEC, Tim44, TMEM102, TMEM184A, TMEM42, TMEM53, TORC3, Tpbpa, Tpbpb, TRAAK, TRIM4, TRIM74, TRK-T3, TROP-2, TSPAN1, TSPAN2, TSSK 1, TSSK 3, TTMP_BC030499, TULP3, UNC119B, UNCX, UNK, Uqcr, UR, Usherin, UT-A, V-ATPase A1, V-ATPase B1, V-ATPase G1, v-Maf, V1RC20, V1RD3, V1RH2, V1RH21, V1RI9, V1RJ3, V3R 10, Veli2, VEPH1, VGLUT1, VILIP-3, VIP, Vmn1r1, Vmn1r167, Vmn1r77, Vmn2r20, Vmn2r47, Vmn2r52, Vmn2r54, Vmn2r68, VMO1, VZV IE62, WAVE3, WFDC10, WFDC1A, Yotiao, YSK4, ZFAT, Zfp13, Zfp747, ZMYND17, ZNF219, ZNF230, ZNF266, ZNF275, ZNF285A, ZNF430, ZNF480, ZNF517, ZNF518B, ZNF568, ZNF580, ZNF654, ZNF697, ZNF764, ZNF800, ZNF865, ZP1, ZPI, ZSCAN5C, and zygin 2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adenosine 3′,5′-cyclic monophosphate, 100 mg | sc-217584 | 100 mg | $116.00 | |||
Adenosine 3′,5′-cyclic monophosphate, 250 mg | sc-217584A | 250 mg | $179.00 | |||
Adenosine 3′,5′-cyclic monophosphate, 5 g | sc-217584B | 5 g | $265.00 | |||
Adenosine 3′,5′-cyclic monophosphate, 10 g | sc-217584C | 10 g | $369.00 | |||
Adenosine 3′,5′-cyclic monophosphate, 25 g | sc-217584D | 25 g | $629.00 | |||
Adenosine 3′,5′-cyclic monophosphate, 50 g | sc-217584E | 50 g | $1150.00 |