YT521-B Inhibitors
The chemical class referred to as YT521-B Inhibitors would consist of compounds that influence the function or expression of YT521-B, an RNA-binding protein associated with the recognition and function of m6A-modified RNA. YT521-B inhibtors mainly encompasses compounds that modulate the methylation and demethylation cycle of RNA, thereby indirectly affecting the availability of m6A-modified RNA substrates that YT521-B would typically bind to.
YT521-B inhibtors influence the levels of S-Adenosylmethionine (SAM), the principal methyl donor in the methylation process, and those that inhibit the activity of enzymes, which are responsible for removing methyl groups from m6A sites on RNA. By altering the methylation status of RNA, these compounds can influence the binding affinity and the functional role of YT521-B in RNA metabolism. Additionally, inhibitors of DNA methyltransferases are included due to their potential secondary effects on RNA methylation patterns. These inhibitors, although targeted primarily at DNA and histones, may affect the methylation landscape at a broader level, including RNA. YT521-B inhibtors alter the availability of the universal methyl donor, S-adenosylmethionine (SAM), thereby affecting the activity of RNA methyltransferases and the function of YT521-B. These inhibitors demonstrate a range of potential indirect methods to influence YT521-B activity through the modulation of m^6A RNA methylation and associated cellular processes.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
Donor of methyl groups for m6A methylation; depletion can reduce substrate availability for m6A writers, indirectly affecting YT521-B binding to m6A sites. | ||||||
Meclofenamic Acid | 644-62-2 | sc-211780 | 5 mg | $402.00 | ||
Inhibits FTO, an m6A demethylase; alteration in m6A demethylation can impact YT521-B recognition of m6A sites. | ||||||
Rhein | 478-43-3 | sc-205837 sc-205837A | 100 mg 500 mg | $267.00 $333.00 | 2 | |
An anthraquinone compound that inhibits FTO; by modulating m6A levels, it can affect YT521-B interactions with RNA. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
A product of SAM-dependent methylation reactions, which can act as an inhibitor of methyltransferases; increased levels can thus indirectly reduce YT521-B binding to m6A-modified RNA. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
DNA methyltransferase inhibitor that could indirectly affect the epigenetic regulation of enzymes involved in m6A RNA methylation, thereby affecting YT521-B function. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA hypomethylating agent that could indirectly affect methylation patterns of RNA as well and thus YT521-B's role. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Another DNA methyltransferase inhibitor that might have indirect effects on RNA methylation and YT521-B activity. | ||||||
1-Aminocyclopentanecarboxylic acid | 52-52-8 | sc-202392 | 1 g | $23.00 | ||
An amino acid analog that inhibits S-adenosylmethionine-dependent methyltransferases, potentially reducing YT521-B's ability to bind m6A-modified RNA. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $52.00 $125.00 $182.00 | 11 | |
A cephalotaxine ester that inhibits protein synthesis; although not directly affecting YT521-B, it may reduce the expression of key proteins involved in m6A RNA modification. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
A cyclin-dependent kinase inhibitor that can alter transcription and potentially impact the expression of m6A writers/readers, including YT521-B. | ||||||