Molecular structure of Homoharringtonine, CAS Number: 26833-87-4
Homoharringtonine (CAS 26833-87-4)
See product citations (11)
Alternate Names:
Omacetaxine mepesuccinate; Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Application:
Homoharringtonine is an inhibitor of diphenylalanine formation & acetylphenylalanyl-puromycin
CAS Number:
26833-87-4
Purity:
≥98%
Molecular Weight:
545.62
Molecular Formula:
C29H39NO9
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Homoharringtonine, a cytotoxic alkaloid found in the bark of the evergreen tree Cephalotaxus harringtonia, is distinguished by its unique mechanism of action that targets protein synthesis in cells. Unlike many compounds that interact with DNA or RNA, homoharringtonine exerts its effects by binding to the ribosomal A-site, thereby inhibiting the elongation phase of protein synthesis. This inhibition is particularly impactful in the realm of cellular biology and molecular research, where homoharringtonine serves as a tool for studying the intricacies of protein synthesis and its role in cell growth and proliferation. The compound′s ability to halt protein translation makes it invaluable in research focused on understanding the cellular pathways that lead to abnormal cell growth. By blocking the synthesis of essential proteins, homoharringtonine can induce apoptosis or programmed cell death, providing a mechanism through which researchers can explore the effects of reduced protein synthesis in various cellular contexts.
Homoharringtonine (CAS 26833-87-4) References
- Homoharringtonine: history, current research, and future direction. | Kantarjian, HM., et al. 2001. Cancer. 92: 1591-605. PMID: 11745238
- Homoharringtonine is safe and effective for patients with acute myelogenous leukemia. | Feldman, E., et al. 1992. Leukemia. 6: 1185-8. PMID: 1434802
- Homoharringtonine: a new treatment option for myeloid leukemia. | Luo, CY., et al. 2004. Hematology. 9: 259-70. PMID: 15621733
- Homoharringtonine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of telomerase. | Xie, WZ., et al. 2006. Am J Chin Med. 34: 233-44. PMID: 16552835
- Selective inhibition of the polypeptide chain elongation in eukaryotic cells. | Tujebajeva, RM., et al. 1992. Biochim Biophys Acta. 1129: 177-82. PMID: 1730056
- Different effects of L-histidinol and homoharringtonine on 5-fluorouracil and bis-chloroethylnitrosourea activity in a murine model. | Warrington, RC. and Fang, WD. 1991. Anticancer Res. 11: 1879-83. PMID: 1768059
- Homoharringtonine-induced hyperglycemia. | Sylvester, RK., et al. 1989. J Clin Oncol. 7: 392-5. PMID: 2645387
- Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor. | Chen, XJ., et al. 2019. Proc Natl Acad Sci U S A. 116: 2220-2225. PMID: 30659143
- Homoharringtonine inhibited breast cancer cells growth via miR-18a-3p/AKT/mTOR signaling pathway. | Wang, LB., et al. 2021. Int J Biol Sci. 17: 995-1009. PMID: 33867824
- Effective therapy for AML with RUNX1 mutation by cotreatment with inhibitors of protein translation and BCL2. | Mill, CP., et al. 2022. Blood. 139: 907-921. PMID: 34601571
- Homoharringtonine is a transdermal granular permeation enhancer. | Watari, A., et al. 2022. Biochem Biophys Res Commun. 616: 140-144. PMID: 35679696
- Homoharringtonine is synergistically lethal with BCL-2 inhibitor APG-2575 in acute myeloid leukemia. | Wei, W., et al. 2022. J Transl Med. 20: 299. PMID: 35794605
- Homoharringtonine Attenuates Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-κB Signaling. | Liu, J., et al. 2022. Mediators Inflamm. 2022: 3441357. PMID: 36211988
Inhibitor of:
2900053A13Rik, 4931406C07Rik, 4933402E13Rik, 9930104L06Rik, ABCE1, ACTBL2, ALG1L, Angiogenesis, BRP44, BXDC1, BXDC5, C10orf132, C14orf152, C19orf61, C1orf109, C1orf70, C1orf77, C21orf70, C2orf12, CNOT6L, CPEB, CPSF3, CPSF4L, CstF-64T, DDX27, DDX51, DDX54, DDX55, DDX56, DENR, Dim1, Dynlt1c, EF-1 γ, EF-1β, EF-1δ, EG621697, EG628456, EG666806, eIF2C3, eIF3β, eIF3δ, eIF3ε, ELAC1, eRF3a, eRF3b, ESF1, EVPLL, FABP5L2, FAM11B, FLRT3, GAGE12C, GGTase-IIβ, Gm3696, Gm5894, GRIP1, GTPBP1, H2-M10.4, H2-M10.5, H2-M9, Hbb-bh1, hCG_1781062, Histone cluster 3 H2ba, HMX3_Hmx3, hnRNP CL1, hnRNP UL1, I920194n01, IF2, ILPIP, IMP-1, IQCF3, JTV1, Kap95, KCTD19, KIAA0329, KIAA1958, KRR1, KRTAP16-10, LARP4, LAS1L, LCRISP2, Lipocalin-3, LOC100039346, LOC100039560, LOC100040448, LOC100040500, LOC100040722, LOC100040857, LOC100041106, LOC100041139, LOC283547, LOC345630, LOC644192, LOC646736, LOC730005, LSG1, MAGOHB, MAGP-2, Mex3c, Mndal, Mnk1, MPP10, MRT4, MUP19, Myosin-15, NACA1, NHPX, NIP7, NLE1, NMD3, Nocturnin, NOL11, NOL8, Nonsense-mediated mRNA decay (NMD) UPF, Nop25, Nopp140, OBFC1, Olfr239, Olr1169, Olr694, P704P, PABPC4L, PABPN (poly(A) binding protein nuclear), Paip2b, pelota, PLGLA1, PLGLB2, POM121, PPIAL4D, PRPF39, QM, Rab 13, RARS2, RBCK1, RBM17, RBM28, RBM32A, RBM35A, RBM4B, RBP, Ribosomal Protein L15, Ribosomal Protein L31, Ribosomal Protein L35A, Ribosomal Protein L36a, Ribosomal Protein L37a, Ribosomal Protein S10, Ribosomal Protein S11, Ribosomal Protein S15, Ribosomal Protein S18, Ribosomal Protein S2, Ribosomal Protein S20, Ribosomal Protein S24, Ribosomal Protein S25, Ribosomal Protein S26, Ribosomal Protein S27L, Ribosomal ProteinL18, RNF170, RPL12, RPL14, RPL15, RPL24, RPL26, RPL39, RPL39L, RPL6, Rpp25, Rpp40, RPS4X, RPS4Y1, RQCD1, RRBP1, RRP9, RRS1, RSL1D1, RSL24D1, SFRS12IP1, Sm B, Sm B′, SMF_Hmgxb3, SMG5, SPAG11A, SRrp35, STAU2, SUSD5, TARSL2, TELO2, TFIIH p44, TFIIIB90, TIA1, Tif, TINP1, TMEM191B, TRAP-α, TSR2, U2 snRNP B′′, Ubie3, Ubr4, UGT2B34, UGT2B35, UTP14A, UTP15, UTP23, V1RA7, V1RA8, V1RB3, WBSCR27, WDR43, WDR74, XRN2, YT521-B, ZC3H12B, ZCCHC14, and ZNF265.Activator of:
BMS1, C11orf59, CIRH1A, CPSF4, DaRS, DDX1, DPH2, DRIM, EG432502, EG665562, eIF2Bγ, eIF3M, eIF4AI, eRF1, ETEA, EXOSC5, Exportin T, LOC345630, Paip1, RALYL, RBMXL1, Ribosomal Protein L10L, Ribosomal Protein L11, Ribosomal Protein L19, Ribosomal Protein L21, Ribosomal Protein L26L1, Ribosomal Protein L27, Ribosomal Protein L32, Ribosomal Protein L35, Ribosomal Protein L35A-like, Ribosomal Protein L36, Ribosomal Protein L38, Ribosomal Protein L3L, Ribosomal Protein L4, Ribosomal Protein L6, Ribosomal Protein L7, Ribosomal Protein L8, Ribosomal Protein LP1, Ribosomal Protein S15, Ribosomal Protein S16, Ribosomal Protein S17, Ribosomal Protein S21, Ribosomal Protein S23, Ribosomal Protein S29, Ribosomal Protein S3A, Ribosomal Protein S8, RPL26L1, RPS2, RPS4Y2, RRP15, SF4, SRP68, TIAR, UROC1, UTP14B, and WDR3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Homoharringtonine, 1 mg | sc-202652 | 1 mg | $51.00 | |||
Homoharringtonine, 5 mg | sc-202652A | 5 mg | $123.00 | |||
Homoharringtonine, 10 mg | sc-202652B | 10 mg | $178.00 |