RheinAn antiinflammatory compoundmwhich induces apoptosis in cancer cell lines

Rhein (CAS 478-43-3)

Rhein | CAS 478-43-3 is rated 5.0 out of 5 by 1.
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Synonym: Rhubarb yellow; Monorhein; Rheic acid
Application: An antiinflammatory compoundmwhich induces apoptosis in cancer cell lines
CAS Number: 478-43-3
Purity: ≥96%
Molecular Weight: 284.22
Molecular Formula: C15H8O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Rhein induces apoptosis in cancer cell lines and inhibits transforming growth factor β-1 induced plasminogen activator inhibitor-1 in endothelial cells.


References

Zhu J, Liu Z, Huang H, Chen Z, Li L. Chin Med J (Engl).116:354-9 (2003). Huang YH, Zhen YS. Yao Xue Xue Bao. 36:334-8 (2001).

Physical State :
Solid
Solubility :
Soluble in 0.1M NaOH (10 mg/ml, Dark Red,Clear to Slightly Hazy ), DMSO (<1 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
≥ 260° C (lit.)
Boiling Point :
~597.8° C at 760 mmHg (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
IC50 :
Hsp90: IC50 = 3.33 µM (human); HepG2: IC50 = 12.3 µM (human); HCT-116: IC50 = 13 µM (human); HePTP: IC50 = 19.62 µM (human); Plec: IC50 = 32.1 µM (human)
pK Values :
pKa: 3.17 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
CA9516000
PubChem CID :
10168
Merck Index :
14: 8176
MDL Number :
MFCD00009618
EC Number :
207-521-4
Beilstein Registry :
2222155
SMILES :
C1=CC2=C(C(=C1)O)C(=O)C3=C(C=C(C=C3C2=O)C(=O)O)O

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Certificate of Analysis

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Rhein  Product Citations

See how others have used Rhein. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23973525  Wang, L. et al. 2013. Biochem. Pharmacol. 86: 991-6.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Duan et al Duan et al. (PubMed ID 2634614) found that Rhein mitigated kidney injury in mice via the wnt/ -catenin pathway. -SCBT Publication Review
Date published: 2015-03-30
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