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5-Aza-2′-Deoxycytidine (CAS 2353-33-5) - chemical structure image — Molecular structure of 5-Aza-2′-Deoxycytidine, CAS Number: 2353-33-5

Molecular structure of 5-Aza-2′-Deoxycytidine, CAS Number: 2353-33-5

5-Aza-2′-Deoxycytidine (CAS 2353-33-5)

Name: 5-Aza-2&prime;-Deoxycytidine | CAS 2353-33-5
Brand: SCBT
SKU: sc-202424
Price: 214.0 USD
Availability: InStock

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See product citations (7)

Alternate Names:

5-Aza-2′-Deoxycytidine is also known as Decitabine.

Application:

5-Aza-2′-Deoxycytidine is a DNMT inhibitor shown to alter gene expression.

CAS Number:

2353-33-5

Purity:

≥99%

Molecular Weight:

228.21

Molecular Formula:

C₈H₁₂N₄O₄

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

5-Aza-2′-Deoxycytidine is a Dnmt inhibitor shown to alter gene expression. 5-Aza-2′-Deoxycytidine has been reported to cause phosphorylation inhibition of 2′-deoxycytidine in certain cells and the incorporation of 2′-deoxycytidine into DNA. Experiments have shown that 5-Aza-2′-Deoxycytidine induces changes in the differentiated state of cultured mouse embryo cells and additionally inhibits methylation of newly synthesized DNA. DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors, and its prevention by 5-Aza-2′-Deoxycytidine can cause gene silencing and transcriptional repression. Other studies suggest that cell exposure to 5-Aza-2′-Deoxycytidine causes a change in replication timing, reactivation of repressed genes, and decondensation of heterochromatin. Furthermore, 5-Aza-2′-Deoxycytidine demonstrates the ability to induce histone hyperacetylation in murine centromeric heterochromatin and also affect intranuclear distribution of histone deacetylase. 5-Aza-2′-Deoxycytidine is also known as Decitabine, 5-Aza-CdR, 5-Aza-dC, and 2′-Deoxy-5-azacytidine.

5-Aza-2′-Deoxycytidine (CAS 2353-33-5) References

DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. | Zhu, WG., et al. 2001. Cancer Res. 61: 1327-33. PMID: 11245429
5-Aza-2'-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation. | Takebayashi, S., et al. 2001. Biochem Biophys Res Commun. 288: 921-6. PMID: 11688997
5-Aza-2'-deoxycytidine reactivates gene expression via degradation of pRb pocket proteins. | Zheng, Z., et al. 2012. FASEB J. 26: 449-59. PMID: 21990374
5-aza-2'-deoxycytidine improves the sensitivity of endometrial cancer cells to progesterone therapy. | Hu, Q., et al. 2012. Int J Gynecol Cancer. 22: 951-9. PMID: 22683940
5-Aza-2''-deoxycytidine inhibits retinoblastoma cell by reactivating epigenetically silenced RASSF1A gene. | Liu, R., et al. 2014. Int J Ophthalmol. 7: 51-6. PMID: 24634863
5-aza-2'-deoxycytidine Inhibits the Proliferation of Lung Fibroblasts in Neonatal Rats Exposed to Hyperoxia. | Zhao, S., et al. 2017. Pediatr Neonatol. 58: 122-127. PMID: 27663361
5-Aza-2'-deoxycytidine increases hypoxia tolerance-dependent autophagy in mouse neuronal cells by initiating the TSC1/mTOR pathway. | Qi, R., et al. 2019. Biomed Pharmacother. 118: 109219. PMID: 31325707
5-Aza-2-deoxycytidine Enhances the Sensitivity of 5-Fluorouracil by Demethylation of the Thymidine Phosphorylase Promoter. | Nishizawa, Y., et al. 2019. Anticancer Res. 39: 4129-4136. PMID: 31366497
Validating the Demethylating Effects of 5-aza-2'-deoxycytidine in Insects Requires a Whole-Genome Approach. | Cook, N., et al. 2019. Am Nat. 194: 432-438. PMID: 31553206
5-Aza-2'-deoxycytidine induces a greater inflammatory change, at the molecular levels, in normoxic than hypoxic tumor microenvironment. | Salviano Soares de Amorim, Í., et al. 2021. Mol Biol Rep. 48: 1161-1169. PMID: 33547534
The Methylation Inhibitor 5-Aza-2'-Deoxycytidine Induces Genome-Wide Hypomethylation in Rice. | Liu, S., et al. 2022. Rice (N Y). 15: 35. PMID: 35779161
Low-dose 5-aza-2'-deoxycytidine protects against early renal injury by increasing klotho expression. | Zhao, Y., et al. 2022. Epigenomics. 14: 1411-1425. PMID: 36695107
Cellular differentiation, cytidine analogs and DNA methylation. | Jones, PA. and Taylor, SM. 1980. Cell. 20: 85-93. PMID: 6156004
Incorporation of a potent antileukemic agent, 5-aza-2'-deoxycytidine, into DNA of cells from leukemic mice. | Veselý, J. and Cihák, A. 1977. Cancer Res. 37: 3684-9. PMID: 71199

Inhibitor of:

α E-catenin, α-Adaptin 2, β-1,3-Gal-TL, β-sarcoglycan, μ-protocadherin, 0610006L08Rik, 0610007N19Rik, 14-3-3 θ, 1700065O13Rik, 2310079F23Rik, 2610110G12Rik, 2810422O20Rik, 2810474O19Rik, 4832428D23Rik, 4921506J03Rik, 4930502E18Rik, 4930525M21Rik, 4933402E13Rik, 5-Methylcytidine, 5830415F09Rik, 7-(2-Hydroxyethyl)guanosine, 7530422B04Rik, A-kinase anchoring protein (AKAP), ACAD-8, ACD, ACOT7, ADAM4, ADAMTS-L2, ADAR3, ADAT3, AdSS1, AdSS2, AHDC1, AHSP, AIP4, ALKBH2, ALS2CL, Aminopeptidase P1, Amnionless, ANKRD11, ANKRD20A5, ANKRD26, ANKRD30B, ANKRD60, ANKRD62, Ankyrin-1, APIP, APOBEC2, apoL11b, APRG1, ARHGAP24, ARID3C, Arp, ART4, ASB-13, ASB-15, ASMTL, Aspartoacylase, ASRGL1, ASZ1, ATR2, ATXN7L3, Azi2, BAF250a, BAF53B, BAF60a, BAGE, BAGE3, BAHD1, BAT2L, BAT4, BAZ1A, BBS6, BC010304, BC067068, BCAS2, BCDIN3, BCoR, Bdf1, Bex4, BHLHB4, BIVM, Bles03, Blood Group AB antigen, Blood Group H2, Blood Group N antigen, BMCP1, BORIS, BTBD12, BTBD9, BTEB2, c-Maf, C10orf105, C10orf131, C11orf51, C11orf57, C12orf56, C12orf62, C12orf71, C14orf102, C14orf131, C14orf56, C19orf25, C19orf54, C1orf156, C1orf25, C22orf31, C2CD2, C3orf14, C3orf21, C3orf37_8430410A17Rik, C3orf38_4930453N24Rik, C3orf59, C3orf64, C5orf35, C6orf120, C6orf167, C6orf32, C6orf47_D17H6S53E, C6orf85, C8orf46, C8orf70, C8orf79_6430573F11Rik, C9orf41, CACNG6, cadherin-8, Calcipressin-3, Calretinin, cbp146, CBX6, CCDC116, CCDC4, CCR-9, CD39L3, CD92, CDYL2, CEACAM5, CECR2, CEM15, Centrin-2, CHMP4, Chox10, Chr-B, CHRAC15, CHST13, Chx10, CLIC5B, CMG1, CMTM2a, CMTM2b, CMV UL146, CNG-β3, Codanin-1, COH1, COL13A, COL7A1, copine 2, Coronin 7, CPA6, CPXCR1, CR1L, CRELD1, CREST, cryptdin 20, cryptdin 23, CTF8, CTGLF6, Cux2, CXorf20, CXorf34, CXorf41, cystatin SA, Cytokeratin 6E, Cytokeratin 7, D530049N12Rik, D630045J12Rik, DACH2, DCAMKL2, Dexras1, DIP2B, DLG5, Dlx-3, Dlx-6, Dmap1, DNA pol ι, DNA2, DNAH10, DNAH12, DNAS1L3, DNC, Dnmt, Dnmt1, Dnmt2, Dnmt3a, DPM3, DPPA5, DPRX, DSC1A, DSC3B, DUX1, DUX3, DUX4L15, DUX5, DUXBL, DYDC2, Dynlt1d, Dynlt1f, DZANK1, E130309D02Rik, EAP30, ECEL1, EF-CBP1, EG236663, EG240921, EG330689, EG333452, EG546205, EG546325, EG666209, EHZF, eIF2C1, EMG1, ephrin-A2, ERC2, ERF, ERM, Erythroid lineage, ESET, Eso-1, ETO, EXTL2, FAM11B, FAM120AOS, FAM165B, FAM168A, FBXO24, FcRH5, Fcrl5, FEV, Fibrillarin-like 1, FLJ36157, FLJ42117, FOG, FOXD4L4, FOXF2, FOXP2, FTSJ1, FTSJ3, FucT-IX, FUS/TLS, fushi tarazu, Gγ 7, GAGE13, GAGE2A, GAGE4, GAGE7B, GAL3ST4, GATA-2, GATC, GBP7, GCF2, GCFC1, GCM2, Get4, GFRα-1, GLT8D4, Glut6, Glutamine-rich 1, Gm428, GMAP-210_TRIP11, GMPPB, GPR42, GPS2, GrapL, Grcc10, Grid2, GSDMC4, GTSF1, GUK1, GXYLT2, H2-Ab, H2-Dd, H2-M1, H2-M10.1, H2-M10.3, H2afb2, H2al2y, H3-K9-HMTase, H60, Hbb-bh1, hCAP-D3, hCG_1795065, HDHD2, HEMK2, Hemoglobin β, Hemoglobin ε, Hemoglobin γ, Hemoglobin ζ, HemT-1, HEN1, HepaCAM, HIC-2, HIGD1C, Histone cluster 1 H2AO, Histone cluster 1 H2BO, Histone cluster 1 H3A, Histone cluster 1 H3C, Histone cluster 1 H3E, Histone cluster 1 H3F, Histone cluster 1 H3H, Histone cluster 1 H3I, Histone cluster 1 H4G, Histone cluster 1 H4H, Histone cluster 1 H4K, Histone cluster 1 H4M, Histone cluster 2 H3A, Histone cluster 2 H3B, Histone cluster 2 H3C, Histone cluster 2 H3D, Histone cluster 2 H4B, Histone H1X, Histone H2A.J, Histone H2A.X, HJURP, HL60 Antigen, HMG-B3, hnRNP E1, Hop2, HoxA13, HoxA2, HoxA7, HoxB1, HoxB3, HoxB6, HoxB7, HoxC4, HoxC9, HoxD3, HoxD4, HP1β, HP1BP3, HPA2a, HPS-3, HSMNP1, hyccin, Id3, IFITM1, IFITM6, IGFBP7, IL-2Rγ, ILT-5, Inhibin β-C, INO80C, INO80D, INSM1, Integrin αIIIb, Intelectin-2, IQCF4, IRF-2BP2, IRX3, IRX4, JMJD1A, JRK, Jumonji, Junctophilin-1, K230010J24Rik, Kaptin, KCNMB4, Khdc1a, KIAA1244, KIAA1429, KIAA1530, KIAA1683, KIR2DL3, KIR3DL2, Klkb1, KLKb11, KLKb9, KLRF1, KLRI1, KRT222, KRTAP1, KRTAP11-1, KRTAP12-4, KRTAP16-4, KRTAP16-8, KRTAP19-3, KRTAP19-7, KRTAP21-1, KRTAP21-2, KRTAP26-1, KRTAP27-1, Krtap31-2, KRTAP8-1, KRTAP8-2, KV4.1, KY peptidase, L3MBTL2, Lacrein, Lambda 5, LBP-1C, Lce1a1, Lce1i, LCRISP2, LDOC1L, LEDGF, LEMD2, LGALS9C, LHFP, LHX4, Limitin, LIN-28, LIN-41, LMP2, LOC100039282, LOC100039452, LOC100039631, LOC100039763, LOC100039799, LOC100039899, LOC100040158, LOC100040208, LOC100040437, LOC100040458, LOC100040491, LOC100040657, LOC100040781, LOC100040870, LOC100040962, LOC100041004, LOC100041032, LOC100041107, LOC100041139, LOC145783, LOC283143, LOC338588, LOC339674, LOC388282, LOC390245, LOC440338, LOC440900, LOC642361, LOC642426, LOC643623, LOC644248, LOC646719, LOC646817, LOC728109, LOC728957, LOC729458, LOC85449, LOH11CR2A, LRRC10, LSAMP, LSm3, LUC7L, Lyl-1, MA1, MacroH2A, MAGE-A1, MAGE-A11, MAGE-A2, MAGE-A3, MAGE-A5, MAGE-A8, MAGE-B18, MAGE-E1, MAGE-E2, MAGE-G1, MAGE-G2, MAGE-H1, MAGI-1b, MAN2B1, MAN2C1, MAP-2A, MAP-2B, MASGP-BP, Maspin, MBD3L2, MBD3L2-5, MBD3L4, MBD3L5, MBD6, MCART1, MCFD2L, MCJ, MCM-BP, MeCP2, MEGF10, MESDC1, MetAP-1, METT10D, METT11D1, METTL12, METTL2, METTL22, METTL23, METTL25, METTL2A, METTL2B, METTL9, MGAT3, MGC50559_4833442J19Rik, MIER3, MILI, Mina53, MITF, MLF1IP, MOR-1, Morc1, Morc3, MORG1, MPDZ, MPHOSPH6, MRG1, MRGBP, MRGX4, MSANTD3-TMEFF1, MTGR1, MTP18, MUP12, MUP15, MUP19, MYBPC3, Myeloid lineage, Myeloid Marker, MZF-1, NALP1A, NAP1L1, NAP1L2, NAP1L4, NASP, NAT-9, NBPF1, NBPF14, NBPF16, NBPF24, NBPF3, NBPF4, netrin G2, Neurexophilin-1, neuroligin 1, NFYB, NIF-1, NIPBL, NKG2-C, Nkx-6.3, Nolz-1, NOP16, NOPE, NOSTRIN, NPAT, NPSF, NRDE-2, NRSF, NSUN1, NSUN2, NSUN3, NSUN4, NSUN5, NSUN5B, NSUN5C, NSUN6, NSUN7, NT5DC2, NY-REN-34, Obox3, Obox5, Oct-1, Odf1, OGFR, Olfr631, Olfr714, Olr694, OR1M1, OR52E8, OR52I2, OR52L1, OR5AS1, OR5B17, OR5J2, OTTMUSG00000016779, OTTMUSG00000016780, OTTMUSG00000016785, OTTMUSG00000016788, OVCH2, p130 Cas, P42pop, P704P, PACE4, PAI-3, PAPD5, PARD6A, parvalbumin β, PASD1, PCBP3OT, PCDH10_Pcdh10, PCDH11Y, PCDH17_Pcdh17, PCDHA1, PCDHA12, PCDHA2, PCDHA3, PCDHB15, Pcdhb22, PCDHGA1, PCDHGA10, PCDHGA12, PCDHGA5, PCDHGA6, PCDHGA7_Pcdhga7, PCDHGA8, PCDHGA9, PCDHGB3, PCMT1, PCMTD1, Peg10, Pegasus, PEMT, Peripherin, PGBD5, PGs2_5730494M16Rik, PHAPI2, PHF20, PHF20L1, PHF21A, PHF23, PHF6, PI 3-kinase C2γ, PIG-B, PIG-T, PIWIL3, PKDREJ, PLAC2, PLAC4, PLAGL1, PLGLA1, PLGLB2, POM121, POTE2β, PP2Cη, PRAME like-4, PRAME like-5, PRAMEF1, PRAMEF11, PRAMEF17, PRAMEF18, PRAMEF2, PRAMEF23, PRAMEF24, PRAMEF25, PRAMEF3, PRAMEF4, PRAMEF5, PRAMEF6, PRAMEF7, PRAMEF9, PRCD, PRDM11, PRDM15, PRDM3, PRDM4, PRDM7, PRDM8, PRDM9, PREP-1, PRHOXNB, Prickle2, PRPS1L1, PRR17, PSF, PSG8, PTPRH, PWWP2A, PWWP2B, Qa-2, R-cadherin, R2, RACK7, Rae-1α, Rae-1β, RAET1L, RAI2, RanBPM, RASSF10, RASSF1A, RASSF1B, RASSF1C, RASSF1D, RASSF1E, RASSF1F, RASSF1G, RBAK, RbAp48, RBBP1, RBBP9, RBM35B, RBM42, RBMY1B, Reg lllα, Repo-Man, REXO2, RFRP, RFX1, RFX2, RFXAP, RG9MTD1, RG9MTD3, RhCE, RhD, Rhox2e, Rhox2g, Rhox2h, RING1, RIZ, RNase Z1, RNGTT, RNMT, RNMTL1, Rsl2, Rslcan-10, Rslcan-13, Rslcan-7, RTDR1, RYBP, SA-2, SAF-B, SAF-B2, SAMHD1, SAPAP3, SATB1, SATB2, SCMH1, SCYL1BP1, SEEK1, SEMA3B, Set1B, SETD2, SETD5, SFMBT2, SHOX2, Sialyltransferase 7C, Siglec-14, Siglec-5, SIM2, Sin3A complex, Sir1, SIRP-α3, Slfn14, Smarcad1, SMCHD1, SMYD1, SNURF, SOCS-7, SorCS3, Sox-11, Sox-17, Sp110, Sp4, SPANX-A, SPIN2, SPINT4, SPNS2, SPOPL, SPR-5, SPT16, SRRM5, SSX2-IP, STAMP2, STELLA, SUHW1, Supt4h2, SUV39H1, SUZ12, SYNJ2BP, SYT, T cell leukemia homeobox (TLX), TAF I p48, TAF II p68, TBC1D24, TBX3, TCF19, TCL-6, TCOF1, TDG, TDRD10, TDRKH, TEF, TES, TET1, TET3, TEX11, TEX15, TFEC, TFIIH p34, TFPT, TGIF, THAP7, THOC2, THSD7A, THUMPD1, TIF1β, TIGD2, TIGD3, TIGD4, tinman, TLE3, TM6SF2, TMC4, TMEM108, TMEM145, TMEM163, TMEM183A, TMEM2, TMEM20, TMEM5, TMEM50B, TMEM65, TNRC18, Tom6, Tomt, Toso, TOX3, TPSB2, transgelin, TRAP240L, TRAX, TRB-1, TRBP2, TRIM10, TRIM5α, TRM11, TRM61, TRMT5, TRMU, Tropomyosin γ, TRRAP, Trypsin-2, TSC-22 D4, TSEN2, TSHZ2, TSPEAR, TSPY2, TSPY8, TSPY9, TSSC3, TWA1, TYW4, UBB, UBE2W, UGT2B10, UGT2B28, UNC5C, UPase 2, USP49, V-ATPase G3, v-Myb, v-SNARE Vti1p, VAMP-2, Vangl2, VCX-A, VCX-B1, VpreB3, VSTM2A, VSX1, WASP, WBSCR22, WDR12, WDR38, WDR5B, WDR62, WDR79, WIZ, WWOX, XAGE-1B, XAP8, XTP3TPA, YT521-B, YTHDC2, ZBED4, ZBP-89, ZBTB2, ZBTB38, ZBTB43, ZBTB8OS, ZC3H7A, ZCCHC6, ZCWCC1, ZCWPW1, ZCWPW2, ZDBF2, ZDHHC9, ZFHX4, ZFOC1, ZFP39, ZFP40, ZFP433, ZFP57, ZFP59, ZFP605, ZFP61, ZFP712, ZFP719, ZFP811, ZFP819, ZFP839, Zfp868, Zfp93, ZFP936, ZFP963, ZFP97, ZFY, ZFY1, ZFY2, ZIM3, ZKSCAN1, ZMYND17, ZNF133, ZNF136, ZNF160, ZNF165, ZNF174, ZNF175, ZNF197, ZNF198, ZNF206, ZNF222, ZNF224, ZNF232, ZNF250, ZNF251, ZNF263, ZNF267, ZNF279, ZNF295, ZNF3, ZNF334, ZNF337, ZNF34, ZNF341, ZNF343, ZNF345, ZNF35, ZNF385A, ZNF397, ZNF397OS, ZNF407, ZNF408, ZNF430, ZNF434, ZNF440, ZNF442, ZNF445, ZNF446, ZNF449, ZNF452, ZNF497, ZNF499, ZNF500, ZNF502, ZNF508, ZNF519, ZNF527, ZNF532, ZNF536, ZNF541, ZNF544, ZNF572, ZNF576, ZNF580, ZNF581, ZNF585A, ZNF596, ZNF619, ZNF621, ZNF623, ZNF625, ZNF649, ZNF672, ZNF677, ZNF70, ZNF711, ZNF717, ZNF720, ZNF730, ZNF740, ZNF75A, ZNF76, ZNF764, ZNF766, ZNF780B, ZNF792, ZNF8, ZNF806, ZNF808, ZNF81, ZNF827, ZNF831, ZNF862, Zonadhesin, ZPI, ZSCAN18, ZSWIM1, ZTL, Zwilch, and ZXDB.

Activator of:

α1-chimaerin, β-Tubulin, β1-Syntrophin, β6 Tubulin, γ-GCSc, μ-protocadherin, 1110059E24Rik, 1110065P20Rik, 1200013P24Rik, 1700001O22Rik, 2810408P10Rik, 5430435G22Rik, 7530422B04Rik, A2LD1, A530016L24Rik, A830010M20Rik, AACT, ABCG4, ACSVL4, ACTR5, Ada1, Ada2, ADAM5, ADAT1, ADE2, Adenovirus-2 E1A, AKNA, AKR7A3, AKR7A5, ALDH1A1, ALKBH5, ANKRD30B, ANKS4B, Ankyrin G, AOF1, AP-4ε, APC1, APOBEC1, APOBEC3A, APOBEC3G, Aprataxin, AREBP, ARHGEF10L, ARID1A, ASCL5, ASGPR2, ASXL2, ASXL3, ATAD2B, atonal, B23, B7-H4, BAF155, BAF250a, BAFL, BAGE3, Barx2, BATF2, BC006662, BC066028, BC066135, Bcl-11a, BCLP, Bestrophin-4, Bex4, BIRC8, BLOS2, BMP-4, BMPR-II, BPAG1, BPTF, BRCAA1, BRD8, Brm, Brn-5, BRWD1, BRWD3, BTBD19, BTF3L4, BTG2, c-Mpl, c-Myb, C10orf6, C10orf71_3425401B19Rik, C11orf65, C14orf131, C14orf39, C14orf56, C16orf88, C17orf76, C19orf64, C1orf101, C1orf112, C1orf114, C1orf122, C1orf141, C1orf175, C1orf181, C1orf185, C1orf186, C1orf216, C1orf227, C1orf25, C1orf50_AU022252, C1orf54, C1orf69, C1orf87, C1orf94, C20orf54, C22orf43, C230099D08Rik, C3orf18, C3orf22, C3orf30, C3orf33, C3orf41, C3orf56, C3orf58, C3orf70, C6orf85, C8orf70, C920016K16Rik, C9orf173, C9orf25, cadherin-28, CALML6, CAMSAP1L1, casein kinase Iε, CBP (CREB Binding Protein), cbp146, CBX7, CCDC21, CCDC6, CCRL2, CD20, CD3, CD47, Cdc27, Cdc2B, CDD, Cdt1, CDYL, CELSR2, CENP-A, CENP-I, CENP-R, Cerebellin 1, CGBP, CHES1, Chromodomain Helicase DNA binding protein (CHD), CHST6, CLAMP, CLCA2_Clac2, CLDND1, CLIC5B, CNIH3, CNOT1, CNOT7, CNT3, COL6A6, Consortin, CrxOS, CSMD2, CSS2, CT45, CT45-3, CtBP2, CTCF, CtIP, CTLA-4, CTPS2, CUL-1, Cux2, cyclin D3, cyclin H, cyclin T1, Cytokeratin 20, CYYR1, D10627, D2Bwg1423e, DAZAP1, DCAMKL2, DDA3, DDO, DEME-6, desmoglein 2, DGCR8, Dicer, Dimethyl Histone H3, DJBP, DLEU7, DMRT1, DMRT2, DMRTC1, DNA pol ε B, DNA pol λ, DNAH14, Dnmt3b, Dnmt3L, Dpb11, DPF2, DPH5, DPRX, DR1, DSC1B, DSC3B, DUPD1, DUX5, Dymeclin, Dynlt1f, E230028L10Rik, E2F-2, E430018J23Rik, EAP1, EDRF1, EFO2, EFR3B, EG236451, EG236663, EG240921, EG245174, EG328644, EG382275, EG385328, EG434123, EG434179, EG626215, EG637776, EG665802, EGL-27, EHZF, eIF3η, emerin, EMID2, Epigen, Erg, ERI-1, ERICH1, ERVK6, ESE-1, ETV3L, EVC, EVI2B, EZHIP, F830116E18Rik, FAM110B, FAM178B, FAM188B2, FAM18B2, FAM44A, FAM55C, FAM69A, FAM72B, FAM83C, Fascin 1, Fascin 3, FBXO27, FBXO8, Fhit, FLJ36157, FLJ43505, FLYWCH1, FOXD4L2, FOXD4L6, FOXE2, FOXJ3, FOXK2, FOXL1, FOXP4, FRAG1, FRBZ1, Freud-1, FRG2C, FRMPD2, FRP-4, FSD2, FSIP2, FucT-l, Gγ 12, G6PD, Gab 1, GABARAPL1, GADD 45α, GADD 45β, GADL1, GAGE10, GAGE12C, GAGE13, GAGE3, GAGE7B, GAS41, GCFC1, GCN5, GDF5OS, GFRα-2, GIOT-2, Gm608, Gm628, GOLGA8B, Gpr165, GPR62, GRSP1, GSDMC3, GTF3A, GTPBP8, GW182, H1T2, H2-Dk, H2-M10.4, H2-M11, H2-M9, H2-Q6, H2-T24, H2afb2, H2AL1, Hbb-b2, HDA7, HEATR5A, HEMK1, Hemoglobin, HIATL1, Histone cluster 1 H1B, Histone cluster 1 H2AC, Histone cluster 1 H2AE, Histone cluster 1 H2AF, Histone cluster 1 H2AI, Histone cluster 1 H2AJ, Histone cluster 1 H2AK, Histone cluster 1 H2AM, Histone cluster 1 H2AN, Histone cluster 1 H2BB, Histone cluster 1 H2BC, Histone cluster 1 H2BF, Histone cluster 1 H2BI, Histone cluster 1 H2BJ, Histone cluster 1 H2BL, Histone cluster 1 H2BM, Histone cluster 1 H2BP, Histone cluster 1 H3B, Histone cluster 1 H3C, Histone cluster 1 H3D, Histone cluster 1 H3E, Histone cluster 1 H3F, Histone cluster 1 H4F, Histone cluster 1 H4I, Histone cluster 1 H4L, Histone cluster 2 H2AA3, Histone cluster 2 H2AB, Histone cluster 2 H2BE, Histone cluster 2 H3A, Histone cluster 2 H3C, Histone cluster 2 H3D, Histone cluster 3 H2A, Histone cluster 3 H3, Histone H1, Histone H10, Histone H2A, Histone H2A.Bbd, Histone H2A.F, Histone H2A.Z, Histone H3.3B, Histone Z, HKIB9, HLA-3, HLA-F`, HLF, HMG I, HMG-14, HMG-1L, HMG-2, HMG-3, HMG-4, HMG-B3, hnRNP A1, hnRNP C, hnRNP E3, hnRNP H′/hnRNP H2, HOS, HoxA10, HoxA4, HoxA5, HoxA9, HoxD1, HoxD9, HPPDL, HPV18 E6, HR, HS3ST3A1, HSPC117, HTR3E, hunchback, I920194n01, IFI-27, IGFBP3, IGSF4C, IL-10, ILDR2, ING2, INO80E, Integrin αIIIb, IQCF2, IQCF3, IQCF6, IQSEC3, IRF-8, ISCA1/1L, Isoc2b, Isw1p, ITFG3, Jade-1, JAZF1, JMJD1B, JMJD3, K-cadherin, K230010J24Rik, Kaiso, karyopherin β2, KAT I, KBTBD6, KBTBD7, KCNA10, KCTD19, Keratin 77, Khdc1a, Khdc1b, KIAA0754, KIAA1045, KIAA1468, KIAA1688, KIAA1704, KIR3DL2, kismet, KK-LC-1, KLF, KLF12, KLHDC7B, KLHL14, Klk1b3, KRBOX1, Krox-26, KRTAP11-1, KRTAP15-1, KRTAP6-3, KRTAP8-1, KV1.7, L3MBTL, Lacrein, LAGE-2A, LAP2, LAS1L, LBXCOR1, LDOC1, LDOC1L, LEKR1_Lekr1, LEUTX, LHFP, LHX8, LIN-1, LIN-28B, LIN-54, LINE-1, Lipocalin-4, LIX1, LKLF, LLGL4, LOC100039210, LOC100039282, LOC100039596, LOC100039674, LOC100039815, LOC100039899, LOC100040657, LOC100040682, LOC100040781, LOC100040885, LOC100040962, LOC100040996, LOC100041177, LOC100041215, LOC100041230, LOC100041244, LOC100041291, LOC100041324, LOC100041407, LOC128977, LOC145837, LOC151174, LOC255130, LOC283143, LOC283547, LOC340094, LOC390245, LOC400958, LOC439950, LOC439994, LOC440900, LOC441461, LOC643072, LOC643749, LOC644135, LOC644248, LOC645323, LOC645359, LOC646522, LOC646719, LOC646817, LOC728957, LOC729454, LOC729991, LRIG2, LRP1B, LRRC54, Lumican, MACF1-4, Mael, MAGE, MAGE-A10, MAGE-A12, MAGE-A4, MAGE-A5, MAGE-A6, MAGE-C2, MAGE-D4, MAGE-D4B, MAGE-E1, MAGE-G2, MALAT-1, MAMDC4, Max, MBD1, MBD2, MBD3L2, MBD3L4, MBD6, MBTD1, MCPyV large T-antigen, MDGA1, Med12l, Med2p, Med4, melanotransferrin, Menin, METTL1, METTL11A, METTL14, METTL4, METTL6, METTL9, MFG-E8, MFSD1, MHC class I, Midnolin, MLF2, MLL5, MPHOSPH8, MRCL3, MRG15, MRGBP, MRGF, MRGX2, mSin3A, mSin3B, MSL-1, MSMP, MTDH, MTH1, Muc21, Mucin 16, Mucin 8, MUM1, MUSTN1, MYBPC2, MYEF2, MyoD, MYSM1, Mystique, N6AMT2, NAP1, NBPF14, NBPF24, NBPF3, NCAM-L1, NEIL1, nephrocystin-5, NESP55, neurexin II, Neurexophilin-1, NFATc2IP, NIPSNAP1, NKG2-A, NKX1-1, Nociceptin, NOL4, NOPAR, nov, NPAL3, NPAS1, NUDT16, NUT, NY-ESO-1, OAS1, OC-2, OC-3, Oct-2, Olfr510, Olfr582, OR13G1, OR5H15, OR5H6, Orexin R-2, Orf Virus, OTTMUSG00000010552, OTTMUSG00000010657, OTTMUSG00000016607, OTTMUSG00000016611, OTTMUSG00000016698, OTTMUSG00000016703, OTTMUSG00000016779, OTTMUSG00000016780, OTTMUSG00000016781, OTTMUSG00000016783, OTTMUSG00000016784, OTTMUSG00000016785, OTTMUSG00000016788, OTTMUSG00000016887, OTTMUSG00000017363, OTTMUSG00000017373, OTTMUSG00000018481, OTX3, P-cadherin, p15, p18, p19 ARF, p57, P704P, p73α, PABPC4, PADI6, Paf1, PAGE-5, Pals2, Pancreasin, PAR-3, Pbx 3, Pbx 4, PCAN1, PCBP3OT, PCDHA11, PCDHA2, PCDHA3, PCDHA4, PCDHAC, PCDHB1, PCDHB2, Pcdhb22, PCDHBPcdhb22, PCDHGA4, PCDHGA7_Pcdhga7, PCDHGB1, PCDHGB2, Pcdhgb4, PCDHGB6, Pcdhgb8, PCDHGC4, PCGF1, PCGF5, PHF13, PHF2, PHF20L1, PHF21B, PHF8, PHKB, PHR1, PIG-S, PLAP, PLK4, Podocalyxin-like 1, POTE14, POTEJ, POU3F3 (Brn-1), Ppp4r1l, PRAME like-3, PRAME like-4, PRAME like-6, PRAME like-7, PRAME_Prame, PRAMEF1, PRAMEF10, PRAMEF12, PRAMEF13, PRAMEF14, PRAMEF16, PRAMEF18, PRAMEF20, PRAMEF23, PRAMEF4, PRAMEF6, PRAMEF7, PRDM10, PRDM12, PRDM14, PRDM5, PRDM6, PRDM7, PREB, preY, PRIP, PRMT5, promethin, Prominin 2, ProSAPiP1, PRR5, PRRT3, pS2, Pumilio 1, Purα, PUS3, pyridoxal phosphatase, QTRTD1, R3HCC1, Rab L5, RAB3IP, RAET1L, RAI1, RASSF1, RASSF1A, RASSF1B, RASSF1C, RASSF1E, RASSF1F, RBA-1, RbAp46, RBBP1, RBP2, RCOR2, RFPL3, RFX1, RG9MTD2, RGPD5, Rhox4e, Rhox4f, Ribosomal Protein L39L, RIG-I, RIP3, RNase HII-B, RNF126, RNF184, RNMTL1, RPAP2, Rpp29, RRP8, Rsl2, Rslcan-11, Rslcan-13, Rslcan-14, Rslcan-2, Rslcan-23, Rslcan-5, Rslcan-6, Rslcan-7, RSRC1, RUNX3, SAMC, SAMD4B, SAMD7, SAP 130, SAP 25_Sap25, SAPAP3, SBZF3, SC35, SCA11, SCCA2, Scgb2a2, SCMH1, SCML1, SEBOX, SerpinB12, SET8, SETBP1, SF3B3, SFMBT1, SH3D19, SIP1, Sir3, Six5, SKT, SLC35F3, Slfn5, Sm D1, SMARCD2, SMARCD3, SMF_Hmgxb3, SMG7, SMYD2, SMYD4, SNF2L, Snf5, SNURF, SorCS3, Spc24, spectrin αII, splicing factor 1, SRp20, SRp40, SRp75, SRRM4, SSEA-1, SSX1, SSX2, SSX2-IP, ST7, STK33, Stra13, Supt4h2, SURF-2, SURF-4, Swi1, Swi3, TAB182, TACE, TADA2L, TAF II p140, TAF II p150, TAF1L, TAFA1, TARBP1, Tastin, TBRG4, TBX15, TCEA1, TCEAL5, TCEAL6, TCFL5, TDRD1, TDRD5, Tektin 2, TEL, TEL2, Teneurin-1, TESSP5, TET2, TEX19, TEX26, TFIIIB90, TFIIIC63, THAP7, THUMPD3, Thy-1, TIG1, TIGD5, TIP60, TM, TM4SF18, TMEM145, TMEM18, TMEM213, TMEM42, TMEM46, TMEM82, TMEM89, TMEM97, TNP2, TPRG1, TRAP100, TRAP240L, TRIM72, TSARG4, TSPY2, TTC14, TTL, TTMP_BC030499, UBE2G1, UBL4B, UBXD7, UHRF1, ULBP1, UPK1B, V-ATPase A4, VCX, VCX-A, VDUP1, VEGF-D, VHL, VILL, VP16, VSIG8, VSTM2B, WDR6, WDSUB1, WHDC1, WHIP, Wingless, Wnt-3a, XAF1, XAGE-1, XAGE-1B, XAP8, XPLAC, YFP, YTHDF2, YY1AP1, ZAC1, ZBBX_FLJ23049, ZBTB25, ZBTB4, ZBTB8, ZC3H13, ZCCHC18, ZDHHC19, ZDHHC22, ZFP106, ZFP14, ZFP141, ZFP287, Zfp781, Zfp870, ZFP873, Zfp874, ZFP91, ZGPAT, ZIM2, ZIM3, ZNF12, ZNF136, ZNF142, ZNF167, ZNF174, ZNF18, ZNF185, ZNF205, ZNF206, ZNF217, ZNF235, ZNF276, ZNF304, ZNF318, ZNF32, ZNF322A, ZNF33A, ZNF33B, ZNF382, ZNF396, ZNF410, ZNF439, ZNF469, ZNF499, ZNF510, ZNF524, ZNF568, ZNF575, ZNF580, ZNF588, ZNF595, ZNF597, ZNF620, ZNF643, ZNF644, ZNF648, ZNF649, ZNF659, ZNF660, ZNF669, ZNF671, ZNF672, ZNF684, ZNF687, ZNF688, ZNF697, ZNF709, ZNF71, ZNF729, ZNF747, ZNF75A, ZNF766, ZNF780B, ZNF792, ZNF814, ZNF821, ZNF828, ZNF85, ZNHIT6, ZRSR2, ZSWIM1, ZSWIM6, and ZXDC.

Ordering Information

Product Name	Catalog #	UNIT	Price	Qty	FAVORITES
5-Aza-2′-Deoxycytidine, 25 mg	sc-202424	25 mg	$214.00
5-Aza-2′-Deoxycytidine, 100 mg	sc-202424A	100 mg	$316.00
5-Aza-2′-Deoxycytidine, 250 mg	sc-202424B	250 mg	$418.00

hello, If I order 1 g, what is the price?

Asked by: Winnie2016

Thank you for your question. For accurate availability, shipping and pricing information regarding our chemical products, please contact Customer Service.

Answered by: Tech Service

Date published: 2019-05-31

Dear sir, this is vertica, senior research fellow, working at biophysics dept, AIIMS. I'm a happy customer of Santa cruz Biotech.I would like to place a request here that can you provide me a sample of this compound so that i could place an order further.

Asked by: Vertica Agnihotri

Thank you for your question. We are so glad to hear that you are a happy customer of Santa Cruz Biotechnology! We do not typically provide sample sizes of our chemical products. If you plan to place a bulk order of this compound, and would first like to test a smaller size, please contact our Special Orders Coordinator. Please e-mail <specialorders@scbt.com>.

Answered by: Technical Support

Date published: 2017-05-31

What is the storage of the compound after being dissolved in water?

Asked by: two2igm05

Thank you for your question. 5-Aza-2′-Deoxycytidine, sc-202424, can be stored for 3 years at -20℃ as a powder or for 6 months at -80℃ in solvent.

Answered by: TechService7

Date published: 2017-01-16

What is the solubility of this chemical?

Asked by: two2igm05

Thank you for your question. This chemical, 5-Aza-2′-Deoxycytidine (CAS 2353-33-5), is soluble in DMSO (45 mg/ml), water (10 mg/ml) and ethanol (<1 mg/ml).

Answered by: Technical Support

Date published: 2016-12-14

Rated 5 out of 5 by FL from SatoSato, N. et al. (PubMed 12591989) studied the effects of 5-Aza-2 -Deoxycytidine, a Dnmt inhibitor shown to alter gene expression, on matrix metalloproteinase (MMP) expression and pancreatic cancer cell invasiveness. They found a significant increase in invasive potential in 4/5 pancreatic cell lines after treatment with 5-Aza-2 -Deoxycytidine. This enhanced invasiveness was associated with the induction on mRNAs for one or more MMPs critical for tumor invasion. -SCBT Publication Review

Date published: 2015-05-08

5-Aza-2′-Deoxycytidine is rated 5.0 out of 5 by 1.

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Test	Specification	Results
Appearance	White or off-white crystalline powder	Complies
Identification (HPLC)	Conforms to structure	Complies
Purity (HPLC)	≥99%	99.94%
Residue on Ignition	≤0.1%	0.08%
Solubility	Hardly soluble in water; slightly soluble in Methanol; soluble in DMSO; practically insoluble in Acetone and in Dichloromethane.	Complies
Solution	Clear and transparent	Complies
Specific Rotation	+56° to +63°	+59.8°
Heavy Metals	≤20 ppm	Complies
Loss on Drying	≤0.5%	0.16%
Related Substances	Single impurity ≤0.2% Total impurities ≤1.0%	0.05%0.06%

5-Aza-2′-Deoxycytidine (CAS 2353-33-5)

5-Aza-2′-Deoxycytidine (CAS 2353-33-5) References

SAMPLE Certificate of Analysis (COA)

TEST CONDITIONS

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5-Aza-2′-Deoxycytidine, 25 mg

5-Aza-2′-Deoxycytidine, 100 mg

5-Aza-2′-Deoxycytidine, 250 mg

hello, If I order 1 g, what is the price?

Dear sir, this is vertica, senior research fellow, working at biophysics dept, AIIMS. I'm a happy customer of Santa cruz Biotech.I would like to place a request here that can you provide me a sample of this compound so that i could place an order further.

What is the storage of the compound after being dissolved in water?

What is the solubility of this chemical?