WCRF Activators
WCRF Activators consist of various chemical entities that enhance the functional activity of WCRF through a series of intracellular signaling events. Forskolin, by elevating intracellular cAMP, activates Protein Kinase A (PKA), which might phosphorylate and activate WCRF or a related regulatory protein that controls WCRF's activity. The same pathway is targeted by 8-Bromo-cAMP and Dibutyryl-cAMP, both analogs of cAMP that penetrate cellular membranes to raise PKA activity, potentially leading to the activation of WCRF. Additionally, Isoproterenol, a beta-adrenergic agonist, increases cAMP levels, indirectly promoting PKA-mediated phosphorylation pathways which could include WCRF activation. Furthermore, the PDE5 inhibitor Sildenafil augments cAMP as well as cGMP levels, which may trigger PKA or PKG to phosphorylate proteins involved in WCRF's activation.
The activity of WCRF is also potentially influenced by modifications in calcium signaling, induced by calcium ionophores like Ionomycin and A23187, which heighten intracellular calcium concentrations and may activate calcium-dependent kinases capable of phosphorylating WCRF. Calcium channel activators such as FPL 64176 and Bay K 8644, likewise, elevate intracellular calcium, leading to the activation of kinases that could target WCRF or associated proteins. Inhibitors of Protein Kinase C (PKC), Bisindolylmaleimide I and Calphostin C, through selective inhibition of PKC isoforms, might paradoxically enhance WCRF activity if WCRF is controlled by PKC-mediated phosphorylation. This collection of compounds, each modulating distinct signaling pathways, converges on the activation of WCRF, thereby amplifying its functional role within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly raises intracellular cAMP levels, which in turn activates PKA (Protein Kinase A). PKA can phosphorylate various proteins, potentially leading to the activation of WCRF by phosphorylation dependent mechanisms, assuming WCRF is a substrate or is regulated by a PKA substrate. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA acts as a potent activator of Protein Kinase C (PKC), which could phosphorylate WCRF or an associated regulatory protein, thereby enhancing WCRF's functional activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways, including PKA, which may lead to the activation of WCRF by phosphorylation of target proteins. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can increase cAMP levels in cells, thereby activating PKA and potentially enhancing WCRF activity if WCRF is modulated by PKA-mediated phosphorylation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which may activate calcium-dependent kinases such as CaMK (Calcium/Calmodulin-dependent protein kinase), potentially leading to the phosphorylation and activation of WCRF. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore similar to Ionomycin, and it increases intracellular calcium, potentially activating WCRF through calcium-dependent signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is another cell-permeable analog of cAMP that can diffuse into cells and activate PKA, potentially leading to the activation of WCRF through phosphorylation. | ||||||
Azelnidipine | 123524-52-7 | sc-252395 | 10 mg | $86.00 | ||
FPL 64176 is a calcium channel activator, potentially increasing intracellular calcium and activating calcium-dependent pathways that could lead to the activation of WCRF. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K 8644 is another calcium channel activator, potentially increasing intracellular calcium concentrations and thus activating WCRF through calcium-dependent signaling mechanisms. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a PKC inhibitor; however, by selectively inhibiting certain PKC isoforms, it could paradoxically lead to the activation of WCRF if WCRF is regulated by a PKC-dependent inhibitory pathway. | ||||||