TSPAN11 Inhibitors
Chemical inhibitors of TSPAN11 function through various mechanisms to disrupt its activity within cell membranes. GW4869, by targeting sphingomyelinase, prevents the formation of ceramide, a critical lipid in the composition of tetraspanin-enriched microdomains where TSPAN11 is active. The absence of ceramide can disorganize these microdomains and impede TSPAN11's function within these structures. Manumycin A, on the other hand, inhibits farnesyltransferase, an enzyme responsible for the post-translational modification of proteins that TSPAN11 interacts with. This inhibition prevents the farnesylation that is necessary for the proper localization and transport of TSPAN11, thereby affecting its function. Similarly, D609 disrupts TSPAN11 activity by inhibiting phosphatidylcholine-specific phospholipase C, which is essential for the production of diacylglycerol, a molecule integral to membrane dynamics and TSPAN11 function.
Perifosine interferes with TSPAN11 by inhibiting Akt signaling, a pathway that helps regulate TSPAN11's localization and function within cell membranes. Imipramine, a broad inhibitor of acid sphingomyelinase, similarly inhibits ceramide formation, which is crucial for TSPAN11's association with lipid rafts, consequently affecting its function. Progesterone, through its interaction with sigma-1 receptors that associate with TSPAN11, can disrupt TSPAN11's functional interactions. U73122, by inhibiting phospholipase C, can disrupt signal transduction pathways involving TSPAN11. Methyl-β-cyclodextrin and Filipin III both target cholesterol within cell membranes, extracting it or binding to it respectively, which disrupts the lipid rafts where TSPAN11 operates, leading to functional inhibition. Genistein, as a tyrosine kinase inhibitor, disrupts signaling pathways that regulate TSPAN11. Monensin alters intracellular ion gradients, influencing TSPAN11 trafficking and function. Lastly, Nystatin, like Methyl-β-cyclodextrin and Filipin III, binds to cholesterol and disrupts lipid rafts, thus inhibiting TSPAN11's role within these membrane microdomains.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $203.00 $611.00 | 24 | |
GW4869 inhibits the activity of sphingomyelinase, which is involved in the generation of ceramide, a lipid that TSPAN11 interacts with during the formation of tetraspanin-enriched microdomains. Inhibition of ceramide generation by GW4869 can disrupt the microdomains and thus inhibit the functional role of TSPAN11 in these regions. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Manumycin A is a farnesyltransferase inhibitor. By inhibiting this enzyme, it prevents the farnesylation of proteins that are essential for the intracellular transport and localization of TSPAN11, thereby inhibiting its function. | ||||||
D609 | 83373-60-8 | sc-201403 sc-201403A | 5 mg 25 mg | $189.00 $575.00 | 7 | |
D609 is a phosphatidylcholine-specific phospholipase C inhibitor, which can inhibit the production of diacylglycerol, a molecule necessary for membrane dynamics where TSPAN11 is known to operate, consequently inhibiting TSPAN11's function. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
Perifosine inhibits Akt signaling, a pathway that can influence the localization and function of TSPAN11 in cell membranes, thereby functionally inhibiting TSPAN11. | ||||||
Imipramine | 50-49-7 | sc-507545 | 5 mg | $190.00 | ||
Imipramine, a non-selective inhibitor of acid sphingomyelinase, can inhibit the formation of ceramide. Since TSPAN11 is associated with lipid rafts where ceramide is a component, disrupting ceramide synthesis can inhibit TSPAN11's function. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone binds to sigma-1 receptors which are known to associate with TSPAN11 in certain cellular contexts. By occupying these receptors, progesterone can disrupt TSPAN11's functional interactions in the cell membrane. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $20.00 $48.00 $160.00 $82.00 | 19 | |
Methyl-β-cyclodextrin extracts cholesterol from cell membranes, disrupting lipid rafts. As TSPAN11 is associated with these rafts, the alteration of raft integrity inhibits TSPAN11's function within these microdomains. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $118.00 $148.00 | 26 | |
Filipin III binds to cholesterol, disrupting lipid rafts within the plasma membrane. TSPAN11, being associated with these rafts, would be functionally inhibited due to the compromised integrity of the rafts. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor and by inhibiting this activity, it can interfere with intracellular signaling pathways, including those regulating the function and localization of TSPAN11, leading to its inhibition. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that disrupts intracellular ion gradients. The alteration of ion homeostasis can influence the trafficking and localization of TSPAN11, thus inhibiting its function in cellular processes. | ||||||