Date published: 2025-11-21

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Monensin A (CAS 17090-79-8)

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Alternate Names:
Monensic acid
Application:
Monensin A is a broad-spectrum anticoccicidial antibiotic also exhibiting antifungal and antiviral activity
CAS Number:
17090-79-8
Purity:
≥95%
Molecular Weight:
670.87
Molecular Formula:
C36H62O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Monensin A is a polyether antibiotic first isolated from Streptomyces cinnamonensis in 1967. Monensin is a broad-spectrum anticoccicidial antibiotic also exhibiting antifungal and antiviral activity. Monensin A forms complexes with monovalent cations such as Li+, Na+, K+, Rb+, Ag+ and Tl+ and is thus able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport and is used in the treatment of animals to prevent coccidiosis, promote growth and prevent bloat. Derivatives of monensin, monensin methyl ester and particularly monensin decyl ester, are used in ion selective electrodes.


Monensin A (CAS 17090-79-8) References

  1. Role of crotonyl coenzyme A reductase in determining the ratio of polyketides monensin A and monensin B produced by Streptomyces cinnamonensis.  |  Liu, H. and Reynolds, KA. 1999. J Bacteriol. 181: 6806-13. PMID: 10542184
  2. Fragmentation studies on monensin A by sequential electrospray mass spectrometry.  |  Lopes, NP., et al. 2002. Analyst. 127: 503-6. PMID: 12022649
  3. Fragmentation study of salinomycin and monensin A antibiotics using electrospray quadrupole time-of-flight mass spectrometry.  |  Miao, XS., et al. 2003. Rapid Commun Mass Spectrom. 17: 149-54. PMID: 12512094
  4. Synthesis, structure and antimicrobial activity of manganese(II) and cobalt(II) complexes of the polyether ionophore antibiotic Sodium Monensin A.  |  Dorkov, P., et al. 2008. J Inorg Biochem. 102: 26-32. PMID: 17692921
  5. Synthesis and antimicrobial properties of monensin A esters.  |  Huczyński, A., et al. 2008. Bioorg Med Chem Lett. 18: 2585-9. PMID: 18375122
  6. Structural characterization and antibacterial activity against clinical isolates of Staphylococcus of N-phenylamide of monensin A and its 1:1 complexes with monovalent cations.  |  Łowicki, D., et al. 2010. Eur J Med Chem. 45: 4050-7. PMID: 20580137
  7. Reinvestigation of the structure of monensin A phenylurethane sodium salt based on X-ray crystallographic and spectroscopic studies, and its activity against hospital strains of methicillin-resistant S. epidermidis and S. aureus.  |  Huczyński, A., et al. 2011. J Antibiot (Tokyo). 64: 249-56. PMID: 21224863
  8. Monensin A acid complexes as a model of electrogenic transport of sodium cation.  |  Huczyński, A., et al. 2012. Biochim Biophys Acta. 1818: 2108-19. PMID: 22564680
  9. Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.  |  Aowicki, D. and Huczyński, A. 2013. Biomed Res Int. 2013: 742149. PMID: 23509771
  10. In vitro metabolism of monensin A: microbial and human liver microsomes models.  |  Rocha, BA., et al. 2014. Xenobiotica. 44: 326-35. PMID: 24134149
  11. Antiproliferative activity of ester derivatives of monensin A at the C-1 and C-26 positions.  |  Klejborowska, G., et al. 2019. Chem Biol Drug Des. 94: 1859-1864. PMID: 31260603
  12. Synthesis and evaluation of antibacterial and trypanocidal activity of derivatives of monensin A.  |  Jędrzejczyk, M., et al. 2022. Bioorg Med Chem Lett. 58: 128521. PMID: 34968675
  13. Hydration of sickle cells using the sodium ionophore Monensin. A model for therapy.  |  Clark, MR., et al. 1982. J Clin Invest. 70: 1074-80. PMID: 7130394

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Monensin A, 5 mg

sc-362032
5 mg
$152.00

Monensin A, 25 mg

sc-362032A
25 mg
$515.00