D609 (CAS 83373-60-8)
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D609 is a selective inhibitor of phosphatidylcholine-specific PLC (PC-PLC). D609 has been employed to establish the functional coupling of PC-PLC with sphingomyelinase and to establish the coupling of PC hydrolysis to the activation of Raf-1 protein kinase. A recent report showed that D609 indirectly inhibits phorbol ester-stimulated PLD activity. D609 possesses antitumor and antiviral activity. D609 also inhibits hypoxia-induced HIF-1α expression via blocking the biosynthesis of phosphatidic acid. D609 has provided benefits after stoke through induction of cell-cycle arrest by up-regulating p21, inhibition of SMS, causing hypophosphorylation of Rb and increased ceramide levels. D609 is a colorless, crystalline solid utilized in various scientific research applications. It possesses a melting point of 198-200°C and a boiling point of 254°C. Its precise mechanism of action remains partially unknown, but it is believed to function as a chelating agent, binding to metal ions in the body and modifying their activity. Moreover, it is considered an antioxidant that combats free radicals and guards against oxidative harm.
D609 (CAS 83373-60-8) References
- D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. | Zhou, D., et al. 2001. J Pharmacol Exp Ther. 298: 103-9. PMID: 11408530
- D609-sensitive tyrosine phosphorylation is involved in Fas-mediated phospholipase D activation. | Kim, JG., et al. 2001. Exp Mol Med. 33: 303-9. PMID: 11795496
- TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown. | Schütze, S., et al. 1992. Cell. 71: 765-76. PMID: 1330325
- Protection by D609 through cell-cycle regulation after stroke. | Adibhatla, RM. and Hatcher, JF. 2010. Mol Neurobiol. 41: 206-17. PMID: 20148315
- Interruption of TPA-induced signals by an antiviral and antitumoral xanthate compound: inhibition of a phospholipase C-type reaction. | Müller-Decker, K. 1989. Biochem Biophys Res Commun. 162: 198-205. PMID: 2751648
- [Supply of dentifrices to the population]. | Keszthelyi, G. and Szabó, I. 1979. Fogorv Sz. 72: 56-61. PMID: 283935
- DNA and RNA virus species are inhibited by xanthates, a class of antiviral compounds with unique properties. | Sauer, G., et al. 1984. Proc Natl Acad Sci U S A. 81: 3263-7. PMID: 6328507
- Inhibitors of basement membrane collagen synthesis prevent endothelial cell alignment in matrigel in vitro and angiogenesis in vivo. | Haralabopoulos, GC., et al. 1994. Lab Invest. 71: 575-82. PMID: 7526036
- Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). | Tschaikowsky, K., et al. 1994. Br J Pharmacol. 113: 664-8. PMID: 7532078
- Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis. | Hooper, DC., et al. 1997. Proc Natl Acad Sci U S A. 94: 2528-33. PMID: 9122229
- Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609. | Pörn-Ares, MI., et al. 1997. Exp Cell Res. 235: 48-54. PMID: 9281351
- Stimulation of DNA synthesis in untransformed cells by the antiviral and antitumoral compound tricyclodecan-9-yl-xanthogenate (D609). | Kiss, Z., et al. 1998. Biochem Pharmacol. 55: 915-8. PMID: 9586966
- Phosphatidylcholine-specific phospholipase inhibitor D609 differentially affects MAP kinases and immediate-early genes in PC12 cells. | Kahle, PJ., et al. 1998. Cell Signal. 10: 321-30. PMID: 9692675
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D609, 5 mg | sc-201403 | 5 mg | $189.00 | |||
D609, 25 mg | sc-201403A | 25 mg | $575.00 |