Molecular structure of Manumycin A, CAS Number: 52665-74-4
Manumycin A (CAS 52665-74-4)
See product citations (5)
Application:
Manumycin A is an antibiotic that acts as a selective and vigorous inhibitor of Ras farnesyltransferase
CAS Number:
52665-74-4
Purity:
≥96%
Molecular Weight:
550.7
Molecular Formula:
C31H38N2O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Manumycin A is an antibiotic originally generated by Streptomyces parvulus that acts as a selective and vigorous inhibitor of Ras farnesyltransferase. The compound has been observed to block the activity of IKKbeta by robustly and rapidly inhibiting TNF alpha induced phosphorylation of IkappaBalpha and NF-kappaB nuclear translocation. Studies indicate that Manumycin A has the ability to induce the dimerization of IKKbeta and dissociation of IKK from IKKgamma/NEMO, the adapter protein. Atherosclerosis studies report that Manumycin A decreases oxidative stress. Additionally, Manumycin A irreversibly inhibits neutral sphingomyelina, and may act to produce nitric oxide and induce apoptosis in leukemia cell studies. Manumycin A is an inhibitor of Farnesyl Transferase and N-SMase.
Manumycin A (CAS 52665-74-4) References
- Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase. | Arenz, C., et al. 2001. Chembiochem. 2: 141-3. PMID: 11828438
- Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells. | She, M., et al. 2005. Leukemia. 19: 595-602. PMID: 15744347
- Binding of manumycin A inhibits IkappaB kinase beta activity. | Bernier, M., et al. 2006. J Biol Chem. 281: 2551-61. PMID: 16319058
- Farnesyltransferase inhibitor, manumycin a, prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice. | Sugita, M., et al. 2007. Arterioscler Thromb Vasc Biol. 27: 1390-5. PMID: 17363690
- The prenylation inhibitor manumycin A reduces the viability of Anaplasma phagocytophilum. | Xiong, Q. and Rikihisa, Y. 2011. J Med Microbiol. 60: 744-749. PMID: 21349982
- Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death. | Singha, PK., et al. 2013. Cell Death Dis. 4: e457. PMID: 23328664
- Suppressive effect of RAS inhibitor manumycin A on aberrant crypt foci formation in the azoxymethane-induced rat colorectal carcinogenesis model. | Tsuda, M., et al. 2013. J Gastroenterol Hepatol. 28: 1616-23. PMID: 23730936
- Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway. | Kim, KH., et al. 2016. Oncol Rep. 36: 117-24. PMID: 27176604
- Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells. | Datta, A., et al. 2017. Cancer Lett. 408: 73-81. PMID: 28844715
- Manumycin A Is a Potent Inhibitor of Mammalian Thioredoxin Reductase-1 (TrxR-1). | Tuladhar, A. and Rein, KS. 2018. ACS Med Chem Lett. 9: 318-322. PMID: 29670693
- Effectors of thioredoxin reductase: Brevetoxins and manumycin-A. | Tuladhar, A., et al. 2019. Comp Biochem Physiol C Toxicol Pharmacol. 217: 76-86. PMID: 30476593
- Combination of photoactive hypericin and Manumycin A exerts multiple anticancer effects on oxaliplatin-resistant colorectal cells. | Macejová, M., et al. 2020. Toxicol In Vitro. 66: 104860. PMID: 32298799
- Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase. | Hagemann, A., et al. 2022. Front Chem. 10: 967947. PMID: 36561140
- Identification of Ras farnesyltransferase inhibitors by microbial screening. | Hara, M., et al. 1993. Proc Natl Acad Sci U S A. 90: 2281-5. PMID: 8460134
- Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes. | Zou, Y., et al. 1996. J Biol Chem. 271: 33592-7. PMID: 8969227
Inhibitor of:
4931429I11Rik, 4932438H23Rik, 9130409I23Rik, AADACL4, ACAP1, AMZ2, Annexin VIII, AP-4β, AP-4σ, ARHGAP12, ARL15, ASAH3L, ATP6V0E2, ATP8A2, cadherin-24, CCZ1, CD1B, Cd1d1, CDS1, CERCAM, claudin-15, CLPTM1L, COL11A1, COL13A1, COL15A1, COL23A1, COL8A2, CR16, DC-SIGNR, DDHD1, DIRAS1, dolichol kinase, DPPL2, DSCR 5, DYX2_D130043K22Rik, ECSIT, EG432555, EXOSC (exosome component), EXOSC2, EXOSC3, FADS7_Degs1, FAM109A, FAM126B, FAPP2, Farnesyl Transferase, FDPS, FND3C2, FTβ, Gα i-2, Gα q, GBGT1, GDPD4, GGPS1 (geranylgeranyl diphosphate synthase 1), GGtase-α, GGTase-Iα, GLIPR1L1, GLTP, Gm266, Gm281, Gm436, Gm996, GPI, GPR155, HAS2, HRASLS2, HRASLS5, ICMT, IGSF4D, Jaw1, Lamin A/C, Langerin, LCE2A, LET-60 RAS, LOC100041282, LPAAT-γ, M6B, Malcavernin, MYH8, MYL1, N-myristoyltransferase 1, N-Ras, N-SMase, NAALADL1, Neurofibromin, Nicalin, ORP-6, PAP-2b, PCDH1_Pcdh1, PCDH19, PCDHB, PCDHGB2, Pcdhgb8, PCYOX1L, Perforin 1, Peroxin 16, PGAP1, PIG-M, PIG-N, PIG-O, PIG-V, PIG-W, PIG-Z, Pilt, PLC ε2, PLC η1, PLEKHF2, PLEKHM2, PLP-Cα, PLP-Cδ, PPAPDC2, PPAPDC3, Progerin, PRX VI, PSG2, PSG3, PSG4, PSG6, PSG7, PSR, PTPLA, R-Ras, R-ras3, Rab 1B, Rab 3 GAP p150, Rab 30, Rab 41, Rab 5B, Rab GTPase (RAB; RAS oncogene), RABAPTIN-5, Rae-1β, Rap 1A, Ras, Ras GAP, Ras-GRF1, RASA4, RASEF, RasGRP1, RasGRP2, RASL10B, RASL11A, RASL12, Rasl2-9, RASSF3, RCE1, Repac, RGL3, RGL4, RSU1, SAA2, SAMD8, Sec23IP, Sec24, Sec4, SERINC1, SERINC4, SMPDL3B, SNAT3, SPACA4, SPACA5, Spint3, SSEA-4, Ste18, TBC1D2, TC 21, TGN38B, TM4SF4, TM9SF2, TMEM168, TMEM31, TMEM39A, TMEM95, TPRX1, TSPAN11, TSPAN8, Vac17p, VAP-A, VPS52, VWA5B1, VWC2L, XG FTase, ZDHHC11B, ZDHHC14, ZDHHC15, ZDHHC6, ZNF585B, and ZNRF2.Activator of:
α-Glucosidase, ACP6, ACTR-IC, AMACO, ARL3, ATP10B, AZI1, BCA3, Cbl-3, CCDC74B, DHDDS, Dist1, FIBCD1, FNDC1, Ganglioside GD2, GGtase-α, Gm996, GOLGA6D, GOLGA8G, Hantavirus, KTELC1, LAMP-1, LAMP-2, LIPH, MAN1A1, MEK-6, Mumps, MVB12B, NEEP21, NKHC1, PGAP1, PIG-C, PIG-H, PIG-W, PIS1, PRA1, PTAR1, Rab 36, Rab 45, Rab 9B, Rab L3, Rab11-FIP5, RASGEF1B, RBJ, SCHIP1, SEC16S, Sec31A, SERAC1, SLC26A6, SWAP-70, TGE Virus, THAP4, TMEM229A, TSPAN6, Veli3, VPS18, VPS26B, Vrho, YIF1A, and ZDHHC11.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Manumycin A, 1 mg | sc-200857 | 1 mg | $215.00 | |||
Manumycin A, 5 mg | sc-200857A | 5 mg | $622.00 |