Molecular structure of Methyl-β-cyclodextrin, CAS Number: 128446-36-6
Methyl-β-cyclodextrin (CAS 128446-36-6)
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Alternate Names:
Methyl-β-cyclodextrin is also known as Methyl-beta-cyclodextrin.
Application:
Methyl-β-cyclodextrin is a randomly methylated form of β-cyclodextrin, a reagent used to increase the solubility of non-polar substances.
CAS Number:
128446-36-6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Methyl-β-cyclodextrin is a reagent used to increase the solubility of non-polar substances such as fatty acids, lipids, vitamins and cholesterol for use in cell culture applications. It contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. The aqueous solubility of various compounds has been improved by Methyl-β-cyclodextrin. It has also been observed to reduce α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.
Methyl-β-cyclodextrin (CAS 128446-36-6) References
- Effects of methyl-beta-cyclodextrin on cryosurvival of boar spermatozoa. | Zeng, WX. and Terada, T. 2001. J Androl. 22: 111-8. PMID: 11191074
- Kinetic degradation study of insulin complexed with methyl-beta cyclodextrin. Confirmation of complexation with electrospray mass spectrometry and (1)H NMR. | Dotsikas, Y. and Loukas, YL. 2002. J Pharm Biomed Anal. 29: 487-94. PMID: 12062649
- Methyl-beta-cyclodextrin stimulates glucose uptake in Clone 9 cells: a possible role for lipid rafts. | Barnes, K., et al. 2004. Biochem J. 378: 343-51. PMID: 14616090
- Effects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathy. | Bar-On, P., et al. 2006. J Neurochem. 98: 1032-45. PMID: 16895578
- Methyl-beta-cyclodextrin improves fertilizing ability of C57BL/6 mouse sperm after freezing and thawing by facilitating cholesterol efflux from the cells. | Takeo, T., et al. 2008. Biol Reprod. 78: 546-51. PMID: 18046011
- Kinetics of cholesterol extraction from lipid membranes by methyl-beta-cyclodextrin--a surface plasmon resonance approach. | Besenicar, MP., et al. 2008. Biochim Biophys Acta. 1778: 175-84. PMID: 18068686
- Effects of methyl-beta-cyclodextrin and cholesterol on cryosurvival of spermatozoa from C57BL/6 mouse. | Movassaghi, S., et al. 2009. Pak J Biol Sci. 12: 19-25. PMID: 19579913
- Enhanced oral absorption of saquinavir with Methyl-Beta-Cyclodextrin-Preparation and in vitro and in vivo evaluation. | Pathak, SM., et al. 2010. Eur J Pharm Sci. 41: 440-51. PMID: 20656025
- Methyl-beta-cyclodextrin induces mitochondrial cholesterol depletion and alters the mitochondrial structure and bioenergetics. | Ziolkowski, W., et al. 2010. FEBS Lett. 584: 4606-10. PMID: 20965172
- Reduced glutathione enhances fertility of frozen/thawed C57BL/6 mouse sperm after exposure to methyl-beta-cyclodextrin. | Takeo, T. and Nakagata, N. 2011. Biol Reprod. 85: 1066-72. PMID: 21778138
- Fluorescently labeled methyl-beta-cyclodextrin enters intestinal epithelial Caco-2 cells by fluid-phase endocytosis. | Fenyvesi, F., et al. 2014. PLoS One. 9: e84856. PMID: 24416301
- Methyl-β-cyclodextrin concurs with interleukin (IL)-4, IL-13 and IL-25 to induce alterations reminiscent of atopic dermatitis in reconstructed human epidermis. | De Vuyst, É., et al. 2018. Exp Dermatol. 27: 435-437. PMID: 27304612
- Preparation and in vitro characterization of rosuvastatin calcium incorporated methyl beta cyclodextrin and Captisol® inclusion complexes. | Al-Heibshy, FNS., et al. 2020. Drug Dev Ind Pharm. 46: 1495-1506. PMID: 32804005
- The effect of methyl-beta-cyclodextrin on DNA absorption and quality of posttransfected sperm. | Rahimi, M., et al. 2021. Poult Sci. 100: 101058. PMID: 33743498
Inhibitor of:
2810008M24Rik, 4930538K18Rik, 4932438H23Rik, Amisyn, ANXA8L2, AP1S2, apoF, apoL7b, APOP1, Baculovirus gp64, caveolin-1, caveolin-2, CD1B, Cd1d1, Clathrin LCA, CTAGE4, CTAGE9, EG665956, ENDOD1, FAM126B, ficolin A, Gα i-3, Gβ 3, Gβ 5, GD3 Synthase, GLIPR1L1, GM2-AP, Gm364, Gm889, GNS, GPAA1, GPI, Hrs-2, LAMP-5, LDLRAD4, LIMP III, LMBRD1, LRP, mucolipin 1, NAGPA, Olfr3, Olfr339, Olfr437, Olfr687, OR2AT4, OR4D1, OR4K15, OR9A4, p60TRP, Paralemmin 3, PCDH19, PCDHB, PCDHB3, PSR, Rab 9 p40, SCARA5, SERINC1, SID-1, SMAGP, StARD6, STON1, STON2, Streptolysin, sulfamidase, SUSD3, Syntaxin 2, T1R3, TM4SF4, TM6SF1, TM9SF1, TMEM118, TMEM166, TMEM168, TMEM200C, TMEM233, TMEM95, TSPAN11, TSPAN3, TSPAN7, VAMP-5, Vmn1r12, VPS26B, and VSV-G.Activator of:
AP-180, ARL6IP4, Arylsulfatase, C17orf59, C230096C10Rik, C8α, caveolin-3, Clathrin HC, Clathrin LCA, COTE1, Dynamin II, EFR3A, Endophilin I, ENSMUSG00000056133, EphA3, Eps15L1, FCHO1, Flotillin-2, GEFT, GLB1L2, GPR171, HEXA, HS3ST4, INO80B, Keratin 73, KRT222, Lad, LEPROT, LIMP I, LIMP III, LOC622554, MANBA, MFSD8, Mumps, Olfr297, Olfr692, Olfr693, Pallidin, PGAP1, POGK, Rab 13, Rab 15, Rab 39B, Rab 45, Rab 7b, Raftlin, RIN2, RIP/Rab, Sar1B, SEB, Sec5, sentan, Sialin, SNX15, SNX32, SPRR2A, STON1, Syntaxin 19, TSPAN6, and VPS18.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methyl-β-cyclodextrin, 100 mg | sc-215379A | 100 mg | $20.00 | |||
Methyl-β-cyclodextrin, 1 g | sc-215379 | 1 g | $48.00 | |||
Methyl-β-cyclodextrin, 5 g | sc-215379B | 5 g | $82.00 | |||
Methyl-β-cyclodextrin, 10 g | sc-215379C | 10 g | $160.00 |