Molecular structure of GW4869, CAS Number: 6823-69-4
GW4869 (CAS 6823-69-4)
See product citations (24)
Alternate Names:
GW4869 also known as N-SMase Inhibitor; GW-4869; GW 4869; Sphingomyelinase; Inhibitor GW4869
Application:
GW4869 is a cell permeable selective inhibitor of N-SMase (neutral sphingomyelinase) which functions as an inhibitor, via a non-competitve manner
CAS Number:
6823-69-4
Purity:
≥90%
Molecular Weight:
577.50
Molecular Formula:
C30H28N6O2•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GW4869 (dihydrochloride hydrate) is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). It functions as an inhibitor via a non-competitve manner. N-SMases are important in the metabolism of sphingomyelin producing ceramide and phosphocholine, which are important in cell signaling and regulation. Studies indicate that GW4869 can inhibit the activation of N-SMase by TNF-alpha in MC7 cells. As a result of this, cell death and growth suppression are inhibited. Although GW4869 does not effect polymorphonuclear neutrophil (PMN) motility, it is useful with formylmethionylleucylphenylanaline (FMLP), since it inhibits PMN aggregation towards the chemotaxin.
GW4869 (CAS 6823-69-4) References
- Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. | Luberto, C., et al. 2002. J Biol Chem. 277: 41128-39. PMID: 12154098
- Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. | Marchesini, N., et al. 2003. J Biol Chem. 278: 13775-83. PMID: 12566438
- An obligate role for membrane-associated neutral sphingomyelinase activity in orienting chemotactic migration of human neutrophils. | Sitrin, RG., et al. 2011. Am J Respir Cell Mol Biol. 44: 205-12. PMID: 20378749
- Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles. | Jung, AL., et al. 2017. Sci Rep. 7: 6301. PMID: 28740179
- Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway. | Trajkovic, K., et al. 2017. J Neurosci. 37: 9000-9012. PMID: 28821645
- Selective release of miRNAs via extracellular vesicles is associated with house-dust mite allergen-induced airway inflammation. | Gon, Y., et al. 2017. Clin Exp Allergy. 47: 1586-1598. PMID: 28859242
- Exosomes derived from embryonic stem cells inhibit doxorubicin and inflammation-induced pyroptosis in muscle cells. | Tavakoli Dargani, Z., et al. 2018. Can J Physiol Pharmacol. 96: 304-307. PMID: 28926719
- Polymer-based precipitation preserves biological activities of extracellular vesicles from an endometrial cell line. | Niu, Z., et al. 2017. PLoS One. 12: e0186534. PMID: 29023592
- Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination. | Tan, LH., et al. 2018. Mol Neurobiol. 55: 5741-5756. PMID: 29043558
- Pathways of production and delivery of hepatocyte exosomes. | Chen, L., et al. 2018. J Cell Commun Signal. 12: 343-357. PMID: 29063370
- Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane. | Menck, K., et al. 2017. J Extracell Vesicles. 6: 1378056. PMID: 29184623
- Dopamine transporter trafficking is regulated by neutral sphingomyelinase 2/ceramide kinase. | Won, JH., et al. 2018. Cell Signal. 44: 171-187. PMID: 29329781
- Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes. | Sobue, A., et al. 2018. Glia. 66: 1034-1052. PMID: 29380419
- Exosomal miR-9 Released from HIV Tat Stimulated Astrocytes Mediates Microglial Migration. | Yang, L., et al. 2018. J Neuroimmune Pharmacol. 13: 330-344. PMID: 29497921
- Mifepristone Inhibits the Migration of Cervical Cancer Cells by Inhibiting Exocrine Secretion. | Sang, L., et al. 2018. Pharmacology. 101: 322-329. PMID: 29621762
Inhibitor of:
1700011H14Rik, 4930538K18Rik, 4932438H23Rik, 4933425O20Rik, 5430405G05Rik, 6430628N08Rik, 9130409I23Rik, ABHD11, Alk-SMase, amelotin, AMMECR1, Ankyrin-1, apoL9b, ARL15, ARMC6, ASAH2B, ASAH3L, ATP8A2, BR-cadherin, C11orf41_D430041D05Rik, Cd1d1, CD1E, Ceramide Kinase, Ceramide Synthase (CERS; LASS), CERKL, CHMP2B, CHMP4A, ChoKB, claudin-15, CLCC1, Dendritic Cell marker, DNAH1, DYX2_D130043K22Rik, Ear5, Ear6, ECSIT, EG432995, EG434008, EG629667, eIF2C1, eIF2C4, EXOSC (exosome component), EXOSC2, EXOSC3, FADS7_Degs1, FAM126B, FAM25A, FAM57B, FAM62A, FAM62C, FAPP2, FCGBP_Fcgbp, FMVB12B, GBGT1, GDC, GDPD4, GLIPR1L1, GLTP, GLTPD1, GM2-AP, GM3 Synthase, Gm436, GOLGA8A, GRAMD1A, GTSF1, HRASLS5, IDAS, KIAA0953, LASS3, LASS4, LCE2A, LDLRAD4, LIPM, Lipophilin A, LOC283999, LOC727949, LPCAT1, LRP11, LRRC21, LRRC8E, LYPD5, MANSC4, MBOAT2, MCP-5, mKIAA0195, MSAP, MTMR14, Mucin 11/12, N-myristoyltransferase 2, N-SMase, N-SMase3, NAALADL1, NAT-8L, Nicalin, O-Ac GD3, OR8D4, ORMDL2, ORMDL3, ORP-6, PALD, PAP-2b, PAPD5, PATL2, PCDH19, PCDHB, PCNXL4, PLAC9, PLEKHA9, PLSCR4, PPAPDC2, PRELID2, PRP2, PSG2, PSS1, PTAG, PTRF, RG9MTD2, RHBDD2, RP24-329J6.2, SAA2, SAMD8, saposin, SDPR, SEC14L1, SERINC1, SERINC4, SLC26A9, SLMO2, SMG9, SMPD5, SMPDL3B, SMS1, SMS2, SNX8, Sorting Nexin (SNX), SPACA5, SPANX-N, SPATA19, Sphingomyelin Synthase 2, SPNS3, SPPL2b, StARD6, syncytin, Tβ-4 Y-linked, T1-cadherin, TBC1D9, TEX101, TIM-4, TM4SF4, TM6SF1, TM7SF3, TMEM105, TMEM106B, TMEM12, TMEM150A, Tmem210, TMEM220, TMEM24, TMEM25, TMEM29, TMEM31, TMEM41A, TMEM41B, TMEM53, TMEM87A, TMEM95, TMEM99, TMEM9B, TSPAN11, TSPAN2, TSPAN3, TSPAN8, VAP-A, Vmn2r50, Vmn2r65, VWDE, ZDHHC12, ZDHHC5, ZDHHC6, ZFYVE28, ZNF496, ZNF626, ZNF665, and ZNRF2.Activator of:
APHC, ASAH2C, DHDDS, Dicer, E030010A14Rik, E030010N08Rik, Ear7, EG432995, hDcp1b, LIN-41, LIPH, MENTHO, mMGL, MVB12B, ORMDL1, ORP-9, SPNS2, Ypk2, and ZDHHC23.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW4869, 5 mg | sc-218578 | 5 mg | $199.00 | |||
GW4869, 25 mg | sc-218578A | 25 mg | $599.00 |