Perifosine (also KRX-0401) is an alkylphospholipid (octadecyl-(1,1-dimethyl-4-piperidylio) phosphate) which inhibits Akt activation. Perifosine has been studied for potential treatment of a wide variety of cancers. Targeting cellular membranes, Perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. Perifosine also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent Miltefosine (sc-203135).
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For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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HOW CAN I DETERMINE THE DOSE OF PERIFOSINE THAT I WILL ADMINISTER IN MICE MODEL/ CELL LINE TO INDUCE AKT-INHIBITION?
Asked by: BUKHARI
Thank you for your question. We have not tested Perifosine: sc-364571 in animals, so we do not have this information. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. Please consult your principal investigator and your animal care and use committee (ACUC) regarding the use of our compounds in animals. We would also recommend you consult the primary literature to determine any previously reported dosing information for inducing Akt inhibition.
Rated 5 out of
Product features are excellentJiang X et al. (PubMed ID30040162 ) found that ANXA8 inhibited Perifosine(the AKT inhibitor) .Combine other results proved ANXA8 activated the phosphorylation of the target protein kinase B (Akt) protein.
Date published: 2019-08-08
Rated 5 out of
Holohan et alHolohan et al. (PubMed ID 26307677) found that the AKT inhibitor, Perifosine, inhibited telomerase activity and induced telomere shortening in various cell lines in vitro -SCBT Publication Review
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