TIM-1 Activators
The class of TIM-1 activators comprises a diverse array of chemical compounds designed to stimulate the T-cell immunoglobulin and mucin domain 1 (TIM-1) protein, a pivotal player in the modulation of cellular processes. One notable direct activator within this class is Forskolin, which operates by stimulating adenylate cyclase, culminating in an elevation of intracellular cAMP levels. This surge in cAMP serves as a catalyst for the activation of downstream signaling pathways intricately associated with TIM-1, thereby fostering TIM-1-mediated cellular processes. An indirect activator, A23187, employs a different strategy by inducing intracellular calcium release, thereby orchestrating modulation of downstream signaling pathways linked to TIM-1. This cascade of events ultimately results in the activation of cellular processes regulated by TIM-1. Furthermore, PMA (Phorbol 12-myristate 13-acetate), another indirect activator, plays its part by stimulating PKC, a pivotal regulator within the TIM-1 signaling pathway. Activation of PKC sets in motion a sequence of downstream events that are indispensable for TIM-1-mediated processes, ultimately leading to the activation of cellular functions under the purview of TIM-1.
The spectrum of activators broadens with compounds like 6-Bnz-cAMP, A769662, Ionomycin, Bisindolylmaleimide I, db-cAMP, AICAR, Thapsigargin, and 8-CPT-cAMP. These compounds exhibit their effects either directly, mimicking the actions of cAMP, or indirectly by influencing key regulators such as PKC and AMPK within the intricate network of the TIM-1 signaling pathway. This collective repertoire of activators provides a valuable toolkit for researchers seeking to delve into targeted interventions and gain deeper insights into the intricate regulatory mechanisms that govern TIM-1. Such exploration proves invaluable across a spectrum of physiological and pathological contexts, contributing significantly to our understanding of cellular processes influenced by TIM-1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates TIM-1 by stimulating adenylate cyclase, leading to an increase in intracellular cAMP levels. Elevated cAMP activates downstream signaling pathways associated with TIM-1, promoting TIM-1-mediated cellular processes. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 activates TIM-1 indirectly by inducing intracellular calcium release. The elevated calcium levels modulate downstream signaling pathways linked to TIM-1, leading to the activation of TIM-1-related cellular processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates TIM-1 indirectly by stimulating PKC, a key regulator in the TIM-1 signaling pathway. PKC activation leads to downstream events crucial for TIM-1-mediated processes, resulting in the activation of TIM-1-related cellular functions. | ||||||
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt | 30275-80-0 | sc-300167 | 10 µmol | $324.00 | 1 | |
6-Bnz-cAMP activates TIM-1 directly by mimicking the effects of cAMP. As a cyclic AMP analog, 6-Bnz-cAMP elevates intracellular cAMP levels, activating downstream signaling cascades associated with TIM-1 and promoting TIM-1-mediated cellular processes. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662 activates TIM-1 indirectly by stimulating AMPK, a key player in the TIM-1 signaling pathway. AMPK activation leads to downstream events crucial for TIM-1-mediated processes, resulting in the activation of TIM-1-related cellular functions. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin activates TIM-1 indirectly by inducing calcium influx. The elevated calcium levels modulate downstream signaling pathways linked to TIM-1, leading to the activation of TIM-1-related cellular processes. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I activates TIM-1 indirectly by inhibiting PKC. The inhibition of PKC disrupts downstream signaling events crucial for TIM-1-mediated processes, resulting in the activation of TIM-1-related cellular functions. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP activates TIM-1 directly by mimicking the effects of cAMP. As a cyclic AMP analog, db-cAMP elevates intracellular cAMP levels, activating downstream signaling cascades associated with TIM-1 and promoting TIM-1-mediated cellular processes. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates TIM-1 indirectly by stimulating AMPK, a key player in the TIM-1 signaling pathway. AMPK activation leads to downstream events crucial for TIM-1-mediated processes, resulting in the activation of TIM-1-related cellular functions. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin activates TIM-1 indirectly by inducing intracellular calcium release. The elevated calcium levels modulate downstream signaling pathways linked to TIM-1, leading to the activation of TIM-1-related cellular processes. | ||||||