Molecular structure of Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt, CAS Number: 30275-80-0
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt (CAS 30275-80-0)
See product citations (1)
Alternate Names:
N6-Benzoyladenosine-3′,5′-cyclic monophosphate sodium salt
Application:
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt is a potent, cell-permeable PKA activator
CAS Number:
30275-80-0
Purity:
≥98%
Molecular Weight:
455.29
Molecular Formula:
C17H15N5O7P•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt is a potent cell permeable activator of both type 1 and type 2 PKA, which are cAMP dependent. Studies indicate that Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt interacts with PKA by binding to site 2 on the regulatory subunit. As a result of PKA activation Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt increases cytosolic calcium ion concentration. In addition, this compound can cross over cell membranes in various cells due to its lipophilic nature. (Note: 10mumol=~4.6mg)
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt (CAS 30275-80-0) References
- Cyclic AMP and calcium interplay as second messengers in melatonin-dependent regulation of Plasmodium falciparum cell cycle. | Beraldo, FH., et al. 2005. J Cell Biol. 170: 551-7. PMID: 16103224
- Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis. | Hochbaum, D., et al. 2008. J Biol Chem. 283: 4464-8. PMID: 18063584
- N6-substituted cAMP analogs inhibit bTREK-1 K+ channels and stimulate cortisol secretion by a protein kinase A-independent mechanism. | Liu, H., et al. 2009. Mol Pharmacol. 76: 1290-301. PMID: 19734321
- cAMP/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: role of CPI-17. | Aslam, M., et al. 2010. Cardiovasc Res. 87: 375-84. PMID: 20202976
- PGE2 inhibits natural killer and gamma delta T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling. | Martinet, L., et al. 2010. Biochem Pharmacol. 80: 838-45. PMID: 20470757
- cAMP-dependent protein kinase from Plasmodium falciparum: an update. | Wurtz, N., et al. 2011. Parasitology. 138: 1-25. PMID: 20663247
- Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability. | Rampersad, SN., et al. 2010. J Biol Chem. 285: 33614-22. PMID: 20732872
- The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization. | Lo, KW., et al. 2012. J Tissue Eng Regen Med. 6: 40-8. PMID: 21312339
- Switching heterotrimeric G protein subunits with a chemical dimerizer. | Putyrski, M. and Schultz, C. 2011. Chem Biol. 18: 1126-33. PMID: 21944751
- EPAC expression and function in cardiac fibroblasts and myofibroblasts. | Olmedo, I., et al. 2013. Toxicol Appl Pharmacol. 272: 414-22. PMID: 23845590
- Signaling transcript profile of the asexual intraerythrocytic development cycle of Plasmodium falciparum induced by melatonin and cAMP. | Lima, WR., et al. 2016. Genes Cancer. 7: 323-339. PMID: 28050233
- Involvement of cyclic adenosine monophosphate-dependent protein kinase isozymes in tissue plasminogen activator secretion by rat Sertoli cells stimulated with follicle-stimulating hormone in vitro. | Laurent-Cadoret, V., et al. 1993. Acta Endocrinol (Copenh). 128: 555-62. PMID: 7687808
- The genetic subtypes of cAMP-dependent protein kinase--functionally different or redundant? | Døskeland, SO., et al. 1993. Biochim Biophys Acta. 1178: 249-58. PMID: 8395890
Inhibitor of:
PKAβ cat.Activator of:
2610015P09Rik, AKAP 12, ARK-2, BSPRY, C4orf28, CALCA, CAPS2, casein kinase Iγ2, CASK, Centrin-4, CIB3, CMYA5, CNIH, DENND1A, Dexras2, EG546901, EphA7, FBL18, GALK1, GPCR2037, HCG3, HSL, KIAA1737, LGR6, NAT-3, NCoA-7, NHEDC1, NRN1L, Olfr569, PKA, PKAγ cat, POM121L12, QSK, SLMAP, SNAP 29, SPAG4, STRAD, Synaptotagmin XVI, TIM-1, TIP120B, TMEM16K, TRAPPC6B, and TTLL2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt, 10 µmol | sc-300167 | 10 µmol | $324.00 |