TIM-1 Inhibitors
The class of TIM-1 inhibitors comprises a collection of diverse chemical compounds that exert inhibitory effects on the T-cell immunoglobulin and mucin domain 1 (TIM-1) protein. Amiloride, a known inhibitor of the Na+/H+ exchanger, indirectly inhibits TIM-1 by inducing alterations in intracellular pH and calcium levels. This modulation disrupts downstream signaling pathways associated with TIM-1, leading to the inhibition of TIM-1-related cellular processes. Tanshinone IIA inhibits TIM-1 indirectly by targeting the PI3K/Akt pathway. Through the suppression of Akt activation, Tanshinone IIA interferes with downstream signaling events crucial for TIM-1-mediated processes, resulting in the inhibition of TIM-1-related cellular functions. Similarly, Wortmannin, a potent inhibitor of phosphoinositide 3-kinase (PI3K), disrupts the signaling cascade associated with TIM-1 activation, ultimately inhibiting TIM-1-related cellular processes.
Tofacitinib, a JAK inhibitor, inhibits TIM-1 indirectly by suppressing JAK-STAT signaling. By interfering with the activation of downstream signaling cascades involved in TIM-1 modulation, Tofacitinib contributes to the inhibition of TIM-1-related cellular processes. Resveratrol, another inhibitor in this class, modulates the MAPK/ERK pathway, disrupting downstream signaling events crucial for TIM-1-mediated processes and resulting in the inhibition of TIM-1-related cellular functions. The class also includes LY294002, which targets PI3K to inhibit TIM-1 indirectly. By suppressing PI3K activity, LY294002 disrupts downstream signaling events, ultimately inhibiting TIM-1-related cellular processes. Bay 11-7082, an inhibitor of the NF-κB signaling pathway, interferes with downstream events crucial for TIM-1-mediated processes, contributing to the inhibition of TIM-1-related cellular functions. These compounds showcase the diverse mechanisms through which the class of TIM-1 inhibitors modulates cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Amiloride inhibits TIM-1 indirectly by blocking the Na+/H+ exchanger, leading to alterations in intracellular pH and calcium levels. These changes impact downstream signaling pathways involved in TIM-1 modulation, ultimately inhibiting TIM-1-related cellular processes. | ||||||
Tanshinone IIA | 568-72-9 | sc-200932 sc-200932A | 5 mg 25 mg | $88.00 $316.00 | 22 | |
Tanshinone IIA inhibits TIM-1 indirectly by modulating the PI3K/Akt pathway. By suppressing Akt activation, this compound interferes with downstream signaling events crucial for TIM-1-mediated processes, resulting in the inhibition of TIM-1-related cellular functions. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin inhibits TIM-1 indirectly by targeting PI3K, a key player in the signaling cascade associated with TIM-1 activation. Through the inhibition of PI3K, Wortmannin disrupts downstream signaling events, ultimately inhibiting TIM-1-related cellular processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol inhibits TIM-1 indirectly by modulating the MAPK/ERK pathway. Through its impact on ERK activation, Resveratrol disrupts downstream signaling events crucial for TIM-1-mediated processes, resulting in the inhibition of TIM-1-related cellular functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits TIM-1 indirectly by targeting PI3K, a key regulator of TIM-1 signaling. By suppressing PI3K activity, LY294002 disrupts downstream signaling events, ultimately inhibiting TIM-1-related cellular processes. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 inhibits TIM-1 indirectly by suppressing the NF-κB signaling pathway. As an inhibitor of IκBα phosphorylation, Bay 11-7082 disrupts downstream signaling events crucial for TIM-1-mediated processes, resulting in the inhibition of TIM-1-related cellular functions. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 inhibits TIM-1 indirectly by targeting p38 MAPK, a key player in TIM-1 signaling. Through the suppression of p38 MAPK activity, SB 203580 disrupts downstream signaling events crucial for TIM-1-mediated processes, resulting in the inhibition of TIM-1-related cellular functions. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI-2536 inhibits TIM-1 indirectly by modulating the cell cycle through PLK1 inhibition. By targeting PLK1, BI-2536 disrupts downstream signaling events crucial for TIM-1-mediated processes, resulting in the inhibition of TIM-1-related cellular functions. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 inhibits TIM-1 indirectly by targeting CHK1, a key player in the DNA damage response pathway. Through the inhibition of CHK1, AZD7762 disrupts downstream signaling events crucial for TIM-1-mediated processes, resulting in the inhibition of TIM-1-related cellular functions. | ||||||