LY 294002 CAS: 154447-36-6
MF: C19H17NO3
LY 294002 is a potent blocker of PI 3-kinase/Akt signaling.

LY 294002 (CAS 154447-36-6)

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Nomi alternativi: 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Applicazione: LY 294002 is a potent blocker of PI 3-kinase/Akt signaling
Numero CAS: 154447-36-6
Purezza: ≥98%
Peso molecolare: 307.34
Formula molecolare: C19H17NO3
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

LY294002 is a potent inhibitor of PI 3-kinase, a protein in the phosphoinositide 3-kinase family of intercellular signal regulating enzymes. This compound is selective for PI 3-kinase p110 β (PI 3-Kβ) and PI 3-kinase p110 α (PI 3-Kα), although it will inhibit other PI 3 kinases at higher concentrations (IC50 = 310 nM and 730 nM for PI 3-Kβ and PI 3-Kα, respectively). The pathway associated with these receptors is implicated in cancer and diabetes, and LY294002 is an important tool for studying this relationship. Reports indicate that LY294002 encourages apoptosis in such cells by blocking the PI 3-kinase/Akt signaling pathway which has been strongly related to cancer survival and proliferation. LY 294002 is an inhibitor of Pim-1, PI 3-kinase p110 δ and PI 3-kinase p110 γ.


Referenze

1. Vanhaesebroeck, B., et al. 1997. Proc. Natl. Acad. Sci. U.S.A. 94: 4330-4335. PMID: 9113989
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Aspetto :
Powder
Stato fisico :
Solid
Solubilità :
Soluble in DMSO (25 mg/ml warm), ethanol (25 mg/ml warm), chloroform, water (< 50 ug/ml) at 25° C, PBS pH 7.2 (< 50 ug/ml), DMF (~16 mg/ml ), and DMSO:PBS(1:1, pH 7.2) (~0.5 mg/ml ).
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
191.76° C (Predicted)
Punto di ebollizione :
~494.6° C at 760 mmHg (Predicted)
Densità :
~1.3 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.63 (Predicted)
IC50 :
Purified PI3K: IC50 = 1.4 µM; Pim-1 kinase : IC50 = 4.0 µM; p110α: IC50 = 0.63 µM; proliferation of choroidal melanoma OCM-1 cells: IC50 = 10 µM; DNA-dependent protein kinase: IC50 = 1.5 µM (human); Serine/threonine-protein kinase PLK3: IC50 = 3 µM (human); PI3K: EC5050 = 1.5 µM (human HeLa cells)
Ki Data :
DNA-dependent protein kinase: Ki= 6 µM (human); PI3-kinase p110-alpha subunit: Ki= 6 µM (human); ATP binding site of Escherichia coli D-alanine-D-alanine ligase B: Ki= 1400 µM
Valori pK :
pKb: 0.55
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
3973
Numero MDL :
MFCD00270881
SMILES :
C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4

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LY 294002 (CAS 154447-36-6)  Citazioni prodotti

Vedi quanti altri hanno usato LY 294002 (CAS 154447-36-6). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 115 totali

PMID: # 31022663  Hsieh, MJ.|Wang, CW.|Lin, JT.|Chuang, YC.|Hsi, YT.|Lo, YS.|Lin, CC.|Chen, MK.| et al. 2019. Phytomedicine. 58: 152805.

PMID: # 31115571  Yu, G.|Wang, C.|Song, X.|Liu, S.|Zhang, Y.|Fan, L.|Yang, Y.|Huang, Y.|Song, J.| et al. 2019. Mol Med Rep. 20: 341-349.

PMID: # 30659232  Salahuddin, S.|Fath, EK.|Biel, N.|Ray, A.|Moss, CR.|Patel, A.|Patel, S.|Hilding, L.|Varn, M.|Ross, T.|Cramblet, WT.|Lowrey, A.|Pagano, JS.|Shackelford, J.|Bentz, GL.| et al. 2019. Sci Rep. 9: 208.

PMID: # 30627006  Zhang, Q.|Chen, K.|Wu, T.|Song, H.| et al. 2019. Korean J. Physiol. Pharmacol. 23: 21-28.

PMID: # 30891489  Jia, Y.|Miyamoto, S.|Soda, Y.|Takishima, Y.|Sagara, M.|Liao, J.|Hirose, L.|Hijikata, Y.|Miura, Y.|Hara, K.|Iwanaga, A.|Ota, Y.|Tani, K.| et al. 2019. Mol Ther Oncolytics. 12: 246-258.

PMID: # 31063758  White, SM.|Avantaggiati, ML.|Nemazanyy, I.|Di Poto, C.|Yang, Y.|Pende, M.|Gibney, GT.|Ressom, HW.|Field, J.|Atkins, MB.|Yi, C.| et al. 2019. Dev. Cell. 49: 425-443.e9.

PMID: # 31087358  2019. Mol. Carcinog. 58: 1492-1501.

PMID: # 30668359  Lin, FZ.|Wang, SC.|Hsi, YT.|Lo, YS.|Lin, CC.|Chuang, YC.|Lin, SH.|Hsieh, MJ.|Chen, MK.| et al. 2019. Phytomedicine. 54: 1-8.

PMID: # 30911300  Aboalola, D.|Han, VKM.| et al. 2019. Stem Cells Int. 2019: 9245938.

PMID: # 30606984  Hamada, K.|Maeda, Y.|Mizutani, A.|Okada, S.| et al. 2019. Biol. Pharm. Bull. 42: 130-138.

Ciatazioni 1 a10 di 115 totali
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