TIM-1 Antibody (A-12): sc-518008
- TIM-1 Antibody (A-12) is a mouse monoclonal IgG1 κ TIM-1 antibody, cited in 11 publications, provided at 200 µg/ml
- raised against amino acids 203-359 mapping at the C-terminus of TIM-1 of human origin
- TIM-1 Antibody (A-12) is recommended for detection of TIM-1 of human origin by WB, IP, IF and ELISA
- Anti-TIM-1 Antibody (A-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TIM-1 Antibody (A-12) for WB applications. These reagents are now offered in bundles with TIM-1 Antibody (A-12) (see ordering information below).
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TIM-1 Antibody (A-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects TIM-1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TIM-1 (A-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TIM-1 , also known as kidney injury molecule 1 or HAVCR1, is a single-pass type I membrane protein that plays a crucial role in the immune system, particularly in the development of T helper 2 (Th2) biased immune responses. TIM-1 is selectively expressed on Th2 cells, which are essential for mediating responses to extracellular pathogens and regulating allergic reactions. Expression of TIM-1 on the surface of these cells allows for the modulation of immune responses, making TIM-1 a significant player in conditions such as asthma and other allergic diseases. Additionally, TIM-1 serves as a receptor for the hepatitis A virus, highlighting TIM-1′s importance in viral pathogenesis. TIM-1 is widely expressed in various tissues, with the highest levels found in the testis and kidney, underscoring TIM-1′s potential roles in both immune regulation and organ-specific functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TIM-1 Antibody (A-12) References:
- Immunology: hepatitis A virus link to atopic disease. | McIntire, JJ., et al. 2003. Nature. 425: 576. PMID: 14534576
- TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. | Umetsu, SE., et al. 2005. Nat Immunol. 6: 447-54. PMID: 15793575
- Evidence for natural selection in the HAVCR1 gene: high degree of amino-acid variability in the mucin domain of human HAVCR1 protein. | Nakajima, T., et al. 2005. Genes Immun. 6: 398-406. PMID: 15889130
- Expression of T cell immunoglobulin- and mucin-domain-containing molecules-1 and -3 (TIM-1 and -3) in the rat nervous and immune systems. | Gielen, AW., et al. 2005. J Neuroimmunol. 164: 93-104. PMID: 15913792
- Regulation of T cell dependent immune responses by TIM family members. | Mariat, C., et al. 2005. Philos Trans R Soc Lond B Biol Sci. 360: 1681-5. PMID: 16147532
- T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation. | de Souza, AJ., et al. 2005. Proc Natl Acad Sci U S A. 102: 17113-8. PMID: 16284246
- Inhibition of in vitro and in vivo T cell responses by recombinant human Tim-1 extracellular domain proteins. | Mesri, M., et al. 2006. Int Immunol. 18: 473-84. PMID: 16481347
- Associations of TIM-1 Genetic Polymorphisms with Asthma: A Meta-analysis. | Xie, X., et al. 2017. Lung. 195: 353-360. PMID: 28434117
- KIM-1/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney. | Mori, Y., et al. 2022. medRxiv.. PMID: 32995803
- Expression of TIM-1 in patients with glioma and its correlation with clinicopathological features. | Zhang, Y. and Chen, P. 2022. Cell Mol Biol (Noisy-le-grand). 68: 43-46. PMID: 37114308
- Role of TIM-1 in the development and treatment of tumours. | Cao, J., et al. 2024. Front Cell Dev Biol. 12: 1307806. PMID: 38831760
- The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. | Feigelstock, D., et al. 1998. J Virol. 72: 6621-8. PMID: 9658108
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIM-1 Antibody (A-12) | sc-518008 | 200 µg/ml | $322.00 | |||
TIM-1 Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-531591 | 200 µg Ab; 10 µg BP | $361.00 | |||
TIM-1 Antibody (A-12): m-IgGκ BP-HRP Bundle | sc-525322 | 200 µg Ab, 40 µg BP | $361.00 | |||
TIM-1 Antibody (A-12): m-IgG1 BP-HRP Bundle | sc-544645 | 200 µg Ab; 20 µg BP | $361.00 | |||
TIM-1 Antibody (A-12) AC | sc-518008 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TIM-1 Antibody (A-12) HRP | sc-518008 HRP | 200 µg/ml | $322.00 | |||
TIM-1 Antibody (A-12) FITC | sc-518008 FITC | 200 µg/ml | $336.00 | |||
TIM-1 Antibody (A-12) PE | sc-518008 PE | 200 µg/ml | $349.00 | |||
TIM-1 Antibody (A-12) Alexa Fluor® 488 | sc-518008 AF488 | 200 µg/ml | $364.00 | |||
TIM-1 Antibody (A-12) Alexa Fluor® 546 | sc-518008 AF546 | 200 µg/ml | $364.00 | |||
TIM-1 Antibody (A-12) Alexa Fluor® 594 | sc-518008 AF594 | 200 µg/ml | $364.00 | |||
TIM-1 Antibody (A-12) Alexa Fluor® 647 | sc-518008 AF647 | 200 µg/ml | $364.00 | |||
TIM-1 Antibody (A-12) Alexa Fluor® 680 | sc-518008 AF680 | 200 µg/ml | $364.00 | |||
TIM-1 Antibody (A-12) Alexa Fluor® 790 | sc-518008 AF790 | 200 µg/ml | $364.00 |