TAF9B Activators
TAF9B Activators are a class of compounds that, while not directly interacting with TAF9B, are capable of modulating cellular pathways and processes that could lead to an enhancement of its function within the transcription machinery. For instance, Forskolin, by increasing cellular cAMP levels, activates protein kinase A (PKA), which can phosphorylate various substrates including transcription factors that may interact with TAF9B, thus enhancing its role in the TFIID complex. Similarly, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which also phosphorylates proteins involved in transcription regulation, potentially co-activating TAF9B within the transcription initiation complex.
Furthermore, compounds like Trichostatin A and sodium butyrate are known HDAC inhibitors, which can lead to changes in chromatin structure, making it more accessible for transcription machinery. This increased accessibility may improve the efficiency of TAF9B as part of the TFIID complex in initiating transcription. 5-Azacytidine and S-Adenosylmethionine are involved in the methylation and demethylation processes of DNA and histones. These modifications are crucial for the regulation of gene expression. By altering the methylation status, these chemicals can potentially affect the binding of TAF9B to DNA and its activity in transcription initiation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels and activation of PKA. PKA can phosphorylate transcription factors and other proteins involved in the transcription initiation complex, which may enhance TAF9B's activity within the TFIID complex. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can then phosphorylate serine and threonine residues on various target proteins, potentially influencing transcription factors that interact with TAF9B, thereby enhancing its role in the TFIID complex. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calmodulin-dependent kinases and potentially enhance TAF9B's activity by modulating the phosphorylation status of proteins interacting with the TFIID complex. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is an inhibitor of histone deacetylases (HDACs). Inhibition of HDACs leads to a more open chromatin structure, which may facilitate transcription initiation by TAF9B-containing TFIID complexes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine incorporates into DNA and RNA, inhibits DNA methyltransferases, and leads to DNA demethylation, potentially enhancing TAF9B's role by affecting transcription factor binding and chromatin remodeling at promoters where TAF9B operates. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid influences gene expression through its receptors, which can interact with transcription complexes. It may enhance TAF9B activity by affecting the transcription of genes where TAF9B is a part of the transcriptional machinery. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, a short-chain fatty acid, acts as an HDAC inhibitor, potentially enhancing TAF9B activity by promoting a transcription-favorable chromatin state, affecting its function in the TFIID complex. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits glycogen synthase kinase 3 (GSK-3), which can lead to the stabilization and activation of transcription factors that may interact with TAF9B, enhancing its transcription regulatory functions. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Analog of cAMP that activates PKA, resulting in enhanced phosphorylation of transcription factors and coactivators, potentially improving TAF9B's functionality in transcription initiation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate transcription factor activity and has been shown to affect histone acetyltransferase (HAT) activity, possibly enhancing the activity of TAF9B by influencing the transcription machinery. | ||||||