TAF II p70 Inhibitors
Chemical inhibitors of TAF II p70 target the protein's role in the transcription initiation complex through various modes of action, primarily by disrupting its interaction with chromatin. Trichostatin A, mocetinostat, entinostat, vorinostat, belinostat, panobinostat, romidepsin, quisinostat, and givinostat all function as histone deacetylase (HDAC) inhibitors. These inhibitors lead to an increase in histone acetylation levels, which in turn can alter the chromatin structure. By changing the acetylation status of histones, these chemical inhibitors can interfere with the normal interactions of TAF II p70 with chromatin, thereby inhibiting its function within the transcription initiation complex. The alteration of chromatin structure is a key mechanism by which these compounds exert their effects on TAF II p70, as the protein's ability to engage with chromatin is essential for its role in initiating transcription.
Flavopiridol operates through a different mechanism, acting as a cyclin-dependent kinase inhibitor. By inhibiting these kinases, flavopiridol can reduce the phosphorylation of proteins that are associated with TAF II p70, which may be crucial for TAF II p70's functional activity in the transcription initiation process. Selisistat, on the other hand, targets sirtuin enzymes, a class of HDACs, which also play a role in deacetylating histones. Through the inhibition of sirtuin activity, selisistat can lead to changes in the acetylation pattern of chromatin, thus affecting TAF II p70's interaction with chromatin. CUDC-907 is unique in that it not only inhibits HDACs but also targets phosphoinositide 3-kinase (PI3K). Although the PI3K inhibition is not directly related to the modulation of TAF II p70, the compound's HDAC inhibitory activity can affect the protein's interaction with chromatin, which is crucial for its role in the transcription initiation complex.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. TAF II p70 functions as part of the transcription initiation complex, and histone acetylation plays a critical role in the regulation of transcription. By inhibiting histone deacetylase, Trichostatin A can increase histone acetylation, thus potentially disrupting the interaction of TAF II p70 with chromatin, leading to the inhibition of its function in the transcription initiation complex. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol is a cyclin-dependent kinase inhibitor. TAF II p70 activity is regulated during the cell cycle, and its function may be modulated by phosphorylation. By inhibiting cyclin-dependent kinases, Flavopiridol could reduce the phosphorylation of proteins associated with TAF II p70, leading to an inhibition of its functional role in transcription initiation. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is a selective inhibitor of certain histone deacetylases. Similar to Trichostatin A, by inhibiting these enzymes, mocetinostat could disrupt the chromatin interactions of TAF II p70, potentially inhibiting its role in the transcription initiation complex due to changes in chromatin structure and histone modification states. | ||||||
EX 527 | 49843-98-3 | sc-203044 | 5 mg | $87.00 | 32 | |
Selisistat is a selective inhibitor of sirtuin enzymes, which are a class of histone deacetylases. By inhibiting sirtuin activity, Selisistat may disrupt TAF II p70's interaction with chromatin by altering histone acetylation levels, thus inhibiting its function in transcription initiation. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat is a benzamide histone deacetylase inhibitor that can alter chromatin structure and gene expression. The inhibition of histone deacetylases by Entinostat could lead to increased acetylation levels, potentially disrupting TAF II p70's engagement with chromatin and inhibiting its function in the transcription initiation complex. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, also known as SAHA, is a histone deacetylase inhibitor that can change gene expression by altering chromatin structure. Vorinostat's inhibition of histone deacetylase could interfere with TAF II p70's chromatin interactions and inhibit its function within the transcription initiation complex. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat is a pan-histone deacetylase inhibitor. It can increase histone acetylation and potentially disrupt the chromatin-related functions of TAF II p70, leading to its inhibition within the transcription initiation complex. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a potent pan-deacetylase inhibitor that could disrupt chromatin interactions and inhibit the function of TAF II p70 by altering the acetylation status of histones and other proteins in the transcription initiation complex. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is a cyclic peptide histone deacetylase inhibitor. Its inhibition of histone deacetylase could change the chromatin landscape, potentially disrupting TAF II p70's role in transcription initiation by modifying the acetylation status of histones. | ||||||
JNJ-26481585 | 875320-29-9 | sc-364515 sc-364515A | 5 mg 50 mg | $321.00 $1224.00 | ||
Quisinostat is a potent histone deacetylase inhibitor. By altering the acetylation status of histones, quisinostat could inhibit the chromatin interactions of TAF II p70, thereby inhibiting its function in the transcription initiation complex. | ||||||