TAF II p70 Activators
TAF II p70 Activators encompass a series of chemical compounds that indirectly enhance the functional activity of TAF II p70 by modulating various signaling pathways and transcription-related processes. Forskolin directly stimulates adenylate cyclase, raising cAMP levels and thus activating PKA, which may phosphorylate transcription factors that recruit TAF II p70 for enhanced coactivator function in the transcription initiation complex. Isoquinoline and Rolipram similarly elevate cAMP, indirectly supporting TAF II p70 activity through prolonged PKA action. Epigallocatechin Gallate (EGCG) and Curcumin indirectly upregulate TAF II p70 by inhibiting DNA methyltransferases and HDACs respectively, leading to a more open chromatin state and potentially higher expression levels of the TAF6 gene. Resveratrol, through SIRT1 activation, may enhance TAF II p70's role by deacetylating transcription factors or coactivators that act in concert with TAF II p70.
Continuing this theme of epigenetic influence, Sodium Butyrate acts as an HDAC inhibitor, promoting histone acetylation which can facilitate transcription factor binding to the TAF6 gene, thus enhancing TAF II p70 activity. 5-Azacytidine reduces DNA methylation at the TAF6 promoter, potentially leading to an upswing in TAF II p70 expression. S-Adenosylmethionine (SAM) impacts the methylation status of histones and could indirectly modify the activity of TAF II p70 by altering the methylation of proteins within the transcription initiation complex. Retinoic Acid, which modulates gene expression via RARs, can further influence the transcriptional coactivation potential of TAF II p70.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate various substrates including transcription factors that interact with TAF II p70, enhancing its coactivator function in the transcription initiation complex. | ||||||
Isoquinoline | 119-65-3 | sc-255224 sc-255224A | 5 g 100 g | $26.00 $58.00 | ||
Isoquinoline indirectly enhances the activity of TAF II p70 by inhibiting phosphodiesterase, which in turn prevents the degradation of cAMP, maintaining the activation of PKA. This sustained PKA activity may lead to increased phosphorylation of transcription factors that associate with TAF II p70. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram, a selective inhibitor of phosphodiesterase 4, increases intracellular cAMP levels, thereby activating PKA. PKA can modulate the transcriptional machinery by phosphorylating TAF6 or associated proteins, enhancing the activity of TAF II p70 in the transcription preinitiation complex. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, the main catechin found in green tea, has been shown to inhibit DNA methyltransferases, which could lead to a decrease in methylation of the TAF6 gene promoter region, potentially resulting in increased TAF II p70 expression and enhanced activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to inhibit histone deacetylases (HDACs). By reducing HDAC activity, curcumin may increase the acetylation of histones at the TAF6 gene locus, enhancing the accessibility of the DNA for transcription and indirectly increasing the functional activity of TAF II p70. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, a member of the sirtuin family of NAD+-dependent deacetylases. Activation of SIRT1 can lead to deacetylation of transcription factors or coactivators that work synergistically with TAF II p70, thus enhancing its role in transcription initiation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can lead to reduced methylation of the TAF6 gene promoter, potentially resulting in increased expression of TAF II p70 and enhanced transcriptional coactivation. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAM serves as a methyl donor for transmethylation reactions and can augment the methylation status of histones. This could indirectly enhance the activity of TAF II p70 by affecting the methylation state of proteins that interact with the transcription initiation complex. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is an HDAC inhibitor that increases the acetylation of histones, potentially enhancing TAF II p70 activity by promoting a chromatin environment that is more accessible for transcription initiation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, the active metabolite of vitamin A, modulates gene expression by activating retinoic acid receptors (RARs). RARs can interact with transcription complexes including those containing TAF II p70, potentially enhancing the protein’s coactivator function. | ||||||