Date published: 2026-8-24

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Curcumin (CAS 458-37-7)

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Alternate Names:
Curcumin is also known as Diferuloylmethane.
Application:
Curcumin is a yellow-orange dye, NOS2 regulator, and inhibitor of NF-κB, 5-LO, Cox-2, COP9, and p300/CBP.
CAS Number:
458-37-7
Purity:
≥95%
Molecular Weight:
368.38
Molecular Formula:
C21H20O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Curcumin is a yellow-orange dye obtained from tumeric, the powdered root of Curcuma longa that is employed in the preparation of curcuma paper, the detection of boron, and possesses a vast number of biological targets. It may act to inhibit NF-κB, possibly through inhibition of JNK (IC50=10 μM). Curcumin blocks amyloid peptide induced expression of: TNF-α, IL-1β, MCP-1, IL-8, and CCR5, regulates NOS2, inhibits IgE and Ag-induced degranulation of mast cells, inhibits 5-LO (5-lipoxygenase) (IC50=8 μM), Cox-2 (cyclooxygenase-2) (IC50=52 μM), the COP9 signalosome kinase (IC50=10 µM), and p300/CBP. This wide range of activities makes Curcumin an extremely useful tool for developing novel analogues and uses.


Curcumin (CAS 458-37-7) References

  1. A review on antibacterial, antiviral, and antifungal activity of curcumin.  |  Moghadamtousi, SZ., et al. 2014. Biomed Res Int. 2014: 186864. PMID: 24877064
  2. A Review of Curcumin and Its Derivatives as Anticancer Agents.  |  Tomeh, MA., et al. 2019. Int J Mol Sci. 20: PMID: 30818786
  3. Antitumor Activity of Curcumin in Glioblastoma.  |  Walker, BC. and Mittal, S. 2020. Int J Mol Sci. 21: PMID: 33322413
  4. Curcumin and Its Potential Impact on Microbiota.  |  Jabczyk, M., et al. 2021. Nutrients. 13: PMID: 34200819
  5. Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones.  |  Flynn, DL., et al. 1986. Prostaglandins Leukot Med. 22: 357-60. PMID: 3460103
  6. Inhibition of human neutrophil 5-lipoxygenase activity by gingerdione, shogaol, capsaicin and related pungent compounds.  |  Flynn, DL., et al. 1986. Prostaglandins Leukot Med. 24: 195-8. PMID: 3467378
  7. Inhibition of tumor necrosis factor by curcumin, a phytochemical.  |  Chan, MM. 1995. Biochem Pharmacol. 49: 1551-6. PMID: 7786295
  8. Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines.  |  Jiang, MC., et al. 1996. Nutr Cancer. 26: 111-20. PMID: 8844727
  9. Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell.  |  Singh, AK., et al. 1996. Cancer Lett. 107: 109-15. PMID: 8913274
  10. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells.  |  Kuo, ML., et al. 1996. Biochim Biophys Acta. 1317: 95-100. PMID: 8950193
  11. Induction of the differentiation of HL-60 promyelocytic leukemia cells by curcumin in combination with low levels of vitamin D3.  |  Sokoloski, JA., et al. 1997. Oncol Res. 9: 31-9. PMID: 9112258
  12. Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation.  |  Kumar, A., et al. 1998. Biochem Pharmacol. 55: 775-83. PMID: 9586949
  13. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin.  |  Chen, YR. and Tan, TH. 1998. Oncogene. 17: 173-8. PMID: 9674701

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Curcumin, 1 g

sc-200509
1 g
$37.00

Curcumin, 5 g

sc-200509A
5 g
$69.00

Curcumin, 25 g

sc-200509B
25 g
$109.00

Curcumin, 100 g

sc-200509C
100 g
$218.00

Curcumin, 250 g

sc-200509D
250 g
$239.00

Curcumin, 1 kg

sc-200509F
1 kg
$879.00

Curcumin, 2.5 kg

sc-200509E
2.5 kg
$1968.00