Panobinostat CAS: 404950-80-7
MF: C21H23N3O2
MW: 349.43

Panobinostat (CAS 404950-80-7)

Panobinostat | CAS 404950-80-7 is rated 5.0 out of 5 by 1.
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Alternate Names: Panobinostat is also known as LBH-589.
Application: Panobinostat is a histone deacetylase (HDAC) inhibitor reported to inhibit human multiple myeloma cell lines.
CAS Number: 404950-80-7
Purity: ≥98%
Molecular Weight: 349.43
Molecular Formula: C21H23N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Panobinostat (LBH589) is an HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells. Panobinostat has potential applications in several different forms of cancer, in addition to spinal muscular atrophy and HIV therapy.


References

1. Catley, L., et al. 2006. Blood. 108: 3441-3449. PMID: 16728695

2. Fiskus, W., et al. 2006. Mol. Cancer Ther. 5: 3096-3104. PMID: 17172412

3. Scuto, A., et al. 2008. Blood. 111: 5093-5100. PMID: 18349321

4. Sasaki, D., et al. 2011. Haematologica. PMID: 21228036. PMID: 21228036

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).
Storage :
Store at -20° C
Melting Point :
>115° C (dec.)
Boiling Point :
608.15° C (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Histone deacetylase: IC50 = 1.8 nM (Plasmodium falciparum); HDAC1: IC50 = 6.8 nM (human); COLO 205: IC50 = 18 nM (human); PC-3: IC50 = 24 nM (human); A2780: IC50 = 35 nM (human)
Ki Data :
HDAC4: Ki= 0.6 nM (human); HDAC2: Ki= 0.65 nM (human); HDAC6: Ki= 0.7 nM (human); HDAC5: Ki= 0.7 nM (human); HDAC1: Ki= 1 nM (human)
pK Values :
pKa: 8.71 (Predicted), pKb: 9.3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UC6378000
PubChem CID :
6918837
MDL Number :
MFCD09833242
SMILES :
CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO

Download SDS (MSDS)

Certificate of Analysis

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Panobinostat (CAS 404950-80-7)  Product Citations

See how others have used Panobinostat (CAS 404950-80-7). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 30515817  Liao, W. et al. 2019. J. Cell. Physiol. 234: 12646-12662.

PMID: # 31054975  Ali, I.|Ruiz, DG.|Ni, Z.|Johnson, JR.|Zhang, H.|Li, PC.|Khalid, MM.|Conrad, RJ.|Guo, X.|Min, J.|Greenblatt, J.|Jacobson, M.|Krogan, NJ.|Ott, M.| et al. 2019. Mol. Cell. 74: 1164-1174.e4.

PMID: # 29778644  Hepp, MI. et al. 2018. Biochim. Biophys. Acta.

PMID: # 26379230  Franken, H. et al. 2015. Nat Protoc. 10: 1567-93.

PMID: # 32365976  Cancers (Basel). 12:

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from An increase in Ac An increase in Ac-Histone H4 protein expression was observed by WB in A549 cells post treatment with Panobinostat. -SCBT QC
Date published: 2015-04-16
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