Panobinostat (LBH589) is an HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells. Panobinostat has potential applications in several different forms of cancer, in addition to spinal muscular atrophy and HIV therapy.
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See how others have used Panobinostat (CAS 404950-80-7). Click on the entry to view the PubMed entry .
PMID: # 30515817 Liao, W. et al. 2019. J. Cell. Physiol. 234: 12646-12662.
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