Molecular structure of MS-275, CAS Number: 209783-80-2
MS-275 (CAS 209783-80-2)
See product citations (24)
Alternate Names:
Entinostat
Application:
MS-275 is an HDAC inhibitor shown to inhibit angiogenesis and metastasis
CAS Number:
209783-80-2
Purity:
≥98%
Molecular Weight:
376.41
Molecular Formula:
C21H20N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MS-275, also known as entinostat, is a benzamide histone deacetylase inhibitor extensively used in research focused on gene expression regulation and epigenetics. It is particularly relevant in studies investigating the mechanisms of chromatin remodeling and its impact on transcriptional activation and silencing. MS-275 is employed to explore the modulation of histone acetylation states and its consequent effects on the cell cycle, differentiation, and apoptosis in various cancer cell lines. Its role in inducing hyperacetylation of histone proteins allows researchers to examine the molecular pathways that govern tumor suppressor gene expression. Furthermore, it is a tool compound in studies that examine the relation of histone deacetylase inhibitors to synaptic plasticity and memory formation.
MS-275 (CAS 209783-80-2) References
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. | Choudhary, C., et al. 2009. Science. 325: 834-40. PMID: 19608861
- The effect of MS-275 on CYP450 isoforms activity in rats by cocktail method. | Wu, Q., et al. 2015. Int J Clin Exp Pathol. 8: 9360-7. PMID: 26464689
- Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension. | Ryu, Y., et al. 2019. PLoS One. 14: e0213186. PMID: 30830950
- MS-275 induces hepatic FGF21 expression via H3K18ac-mediated CREBH signal. | Zhang, Q., et al. 2019. J Mol Endocrinol. 62: 187-196. PMID: 30893641
- MS-275 potentiates the effect of YM-155 in lung adenocarcinoma via survivin downregulation induced by miR-138 and miR-195. | Luo, BL., et al. 2019. Thorac Cancer. 10: 1355-1368. PMID: 31090206
- Histone deacetylases inhibitor MS-275 suppresses human esophageal squamous cell carcinoma cell growth and progression via the PI3K/Akt/mTOR pathway. | Ma, S., et al. 2019. J Cell Physiol. 234: 22400-22410. PMID: 31120582
- MS-275 Chemical Analogues Promote Hemoglobin Production and Erythroid Differentiation of K562 Cells. | Voskou, S., et al. 2019. Hemoglobin. 43: 116-121. PMID: 31280628
- Histone Deacetylase Inhibitor MS-275 Alleviates Postoperative Cognitive Dysfunction in Rats by Inhibiting Hippocampal Neuroinflammation. | Wu, Y., et al. 2019. Neuroscience. 417: 70-80. PMID: 31430527
- MS-275 combined with cisplatin exerts synergistic antitumor effects in human esophageal squamous cell carcinoma cells. | Liu, T., et al. 2020. Toxicol Appl Pharmacol. 395: 114971. PMID: 32217144
- Histone deacetylase inhibition by MS-275 potentiates glucose-stimulated insulin secretion without affecting glucose oxidation. | Zhang, Y., et al. 2020. Life Sci. 257: 118073. PMID: 32663574
- MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice. | Bele, S., et al. 2020. Elife. 9: PMID: 33349332
- HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells. | Kashio, T., et al. 2021. Tissue Barriers. 9: 1911195. PMID: 33955828
- Identification and Exploration of Novel Macrophage M2-Related Biomarkers and Potential Therapeutic Agents in Endometriosis. | Cui, Z., et al. 2021. Front Mol Biosci. 8: 656145. PMID: 34295919
- MS-275 (Entinostat) Promotes Radio-Sensitivity in PAX3-FOXO1 Rhabdomyosarcoma Cells. | Cassandri, M., et al. 2021. Int J Mol Sci. 22: PMID: 34639012
Inhibitor of:
1200013P24Rik, 2900008C10Rik, 4632411B12Rik, 4930502E18Rik, 4930557A04Rik, A-Myb, A530032D15Rik, Abi-2, Acatin, AHDC1, AIP4, Angiogenesis, ANKRD11, ANKRD20A5, ANKRD26, ANKRD60, APOBEC2, ARID3C, ASF1B, ASH2L, ASXL3, BAF250a, BAF53B, BAGE3, BAGE4, BAHD1, BAZ1A, BAZ2B, BCoR, BCORL1, BEND7, Blood Group H2, BMAL2, BORIS, BPTF, BRCA1, BRMS1L, Brpf1, BRWD1, BRWD3, Btnl1, C14orf43, C1orf181, C1orf43, C1orf83, C20orf165, C2CD2, C5orf35, C9orf41, cbp146, CBX6, CCDC116, CDY2, CDYL2, CECR2, Chr-B, CHRAC15, CLIM-1, Codanin-1, COL13A, CPA6, CREST, DCAMKL2, Dimethyl Histone H3, Dmap1, DNC, DNHD1, DNHD2, DPF3, DPRX, DPY-30, Dpy30, DUX3, DYDC2, Dynlt1d, Dynlt1f, EAP30, EG666209, Elongin C, Eso-1, EZHIP, EZI, FAM11B, FAM120AOS, FcRH5, FLJ36157, FLJ42117, FOXD4L3, FOXD4L4, FOXF2, FRYL, GAGE, GAGE12G, GAGE13, GAGE2A, GAGE4, GAS41, GATAD (GATA zinc finger domain containing), GATAD2A, Gm806, GMAP-210_TRIP11, GPR42, H2-A, H2-M10.1, H2-M10.2, H2afb2, H2AL1, H2al3, H2BFWT, H3.Y histone 1, H3.Y Histone 2, H60, HAT1, Hat2, Hbb-y, HCF2, hCG_1795065, HDA1, HDA2, HDA4, HDA5, HDA7, HDAC, HDAC1, HDAC11, HDAC2, HDAC3, HDAC5, HDAC6, Helios, HESL, Hils1, His-probe, Histone B, Histone cluster 1 H1C, Histone cluster 1 H1D, Histone cluster 1 H1E, Histone cluster 1 H1T, Histone cluster 1 H2A, Histone cluster 1 H2AA, Histone cluster 1 H2AA2, Histone cluster 1 H2AG, Histone cluster 1 H2AK, Histone cluster 1 H2AM, Histone cluster 1 H2AO, Histone cluster 1 H2B, Histone cluster 1 H2BA, Histone cluster 1 H2BC, Histone cluster 1 H2BE, Histone cluster 1 H2BF, Histone cluster 1 H3B, Histone cluster 1 H3E, Histone cluster 1 H3H, Histone cluster 1 H4, Histone cluster 1 H4F, Histone cluster 1 H4J, Histone cluster 1 H4K, Histone cluster 2 H2AA1, Histone cluster 2 H2AA3, Histone cluster 2 H2AC, Histone cluster 2 H3A, Histone cluster 2 H3C1, Histone cluster 2 H3C2, Histone cluster 2 H3D, Histone cluster 2 H4, Histone cluster 3 H3, Histone H1, Histone H10, Histone H1B, Histone H2A, Histone H2A.Bbd, Histone H2A.V, Histone H2A.X, Histone H2B, Histone H2B.S, Histone H3, Histone H3.3B, Histone H4, Histone Z, hIws1, HLF, HMG-B3, hnRNP U, HoxA7, HoxA9, HoxB6, HP1, HP1BP3, IINTS1, ING5, Inhibin β-C, INO80D, JAZF1, K230010J24Rik, KCNMB4, Khdc1a, KIAA1244, Klkb1, KLRI1, KMT5 (lysine methyltransferase), KMT5A (Lysine Methyltransferase), KRT222P, KRTAP19-3, KRTAP21-2, KRTAP8-2, L3MBTL, Lacrein, Lce1a1, Lce1g, LDOC1L, LIN-35, LIN-53, Lipocalin-11, LOC100039631, LOC100039763, LOC100039799, LOC100040208, LOC100040458, LOC100040491, LOC100040657, LOC100040781, LOC100040962, LOC100041004, LOC100041179, LOC100041274, LOC145783, LOC390245, LOC642426, LOC646817, LOC665622, LOC729458, Lyl-1, MacroH2A2, Mael, MAGE-A11, MAGE-A2, MAGE-A9, MAGE-A9B, MAGE-B1, MAGE-B18, MAGE-B3, MAGE-B5, MAGE-E1, MAGE-E2, MAGE-F1, MAGE-G2, mage-k1, Mammaglobin A, MAN2B1, MASGP-BP, MCART1, MetAP-1, Mettl7a2-Higd1c, Mi2-α, MIER1, MIER3, MOF, Morc, Morc1, Morc3, MORF4L2, MRG15, MRGBP, MRGX4, mSin3A9, Msx-3, MTGR1, Mxi 1, NAP1L2, NAP1L5, NAP5, NBPF24, neuroligin X/Y, NIF-1, NKAP, Npcd, NPSF, NRDE-2, NRSF, Nup62-il4i1, NWD1, NY-REN-34, Obox3, Obox5, OCIAD1, OR1M1, OR52A1, OR52E8, OR52L1, OTTMUSG00000016789, OTTMUSG00000016790, OTTMUSG00000016887, OTTMUSG00000018481, OTTMUSG00000018888, p130 Cas, p150, p400, PAGE-2, pan-Acetyl, parvalbumin β, PATE2, PCDH11Y, PCDHA1, PCDHA12, PCDHAC2_Pcdhac2, PCDHB13, Pcdhb22, PCDHGA1, PCDHGA5, PCDHGA6, PCDHGB5, PCDHGB6, PEG3, PGs2_5730494M16Rik, PHF12, PHF13, PHF16, PHF2, PHF20L1, PHF21A, PHF21B, phostensin, PKDREJ, PLAC4, PNP2, POTEJ, POU6F2, PP2Cη, PRAMEF10, PRAMEF12, PRAMEF14, PRAMEF16, PRAMEF17, PRAMEF18, PRAMEF23, PRAMEF5, PRAMEF9, PRDM10, PRDM15, PRDM16, PRDM7, PRDM8, PRDM9, PRHOXNB, PRR20A, PRR20C, PRR20D, PRR20E, PRSS55, PSD3, PSF, PSKH2, PTPRH, PWWP2A, PWWP2B, RACK7, RAI15, RAI2, RASSF1B, RASSF1G, RBBP1, RBM35B, Reg lllα, RhD, RIZ, RNMTL1, RP2, RP23-480B19.10, Rslcan-13, SAMD4B, SAP 130, SAP 25_Sap25, SAP 30BP, SAP 30L, SCMH1, SCML4, SDS3, SETD5, SFMBT2, Siglec-5, SIM2, Sin3, Slfn11, Slfn5, SMYD1, SMYD2, SMYD4, SNF2L, Snf5, SNURF, SorCS3, Sp9, SPANX-A-F, SPIN2, SPNS2, SRRM5, ST7, STAMP2, STOX2, Subh2bv, SUT-1, Synovial sarcoma X (SSX) breakpoint protein, TAF I p48, TAF II p68, TAF II p70, TAF6L, TAF9A, TBX15, TDRD1, TGIF2, THAP7, TIGD2, TIGD3, TIGD4, TMEM103, TOX3, TRRAP, TSPY8, TSPY9, TSPYL4, TSSC3, TSSC4, TTC1, Tup1, UBN-1, USP49, V1RH18, VPS72, VSTM2A, VSX1, WCRF, WDR33, WDR62, WDR79, WIZ, YDJC, YEATS2, ZBP-89, ZBTB40, ZC3H13, ZCWPW1, ZCWPW2, ZFP383, ZFP39, ZFP40, ZFP433, ZFP563, ZFP59, ZFP605, ZFP61, ZFP712, ZFP719, Zfp78, ZFP811, ZFP819, ZFP839, Zfp868, Zfp93, Zfp931, ZFP936, ZFP963, ZFP97, ZFY1, ZFY2, ZIM3, ZKSCAN1, ZMYM6NB, ZMYND12, ZMYND17, ZNF165, ZNF175, ZNF197, ZNF198, ZNF224, ZNF232, ZNF250, ZNF251, ZNF267, ZNF322A, ZNF334, ZNF337, ZNF34, ZNF341, ZNF343, ZNF385A, ZNF430, ZNF445, ZNF500, ZNF502, ZNF508, ZNF519, ZNF532, ZNF536, ZNF57, ZNF572, ZNF588, ZNF606, ZNF619, ZNF621, ZNF623, ZNF625, ZNF649, ZNF711, ZNF740, ZNF764, ZNF780B, ZNF81, ZNHIT1, and ZSCAN1.Activator of:
1700011H14Rik, 2900008C10Rik, 4930557A04Rik, ADA3, AFF4, ASCL2, ASXL2, ATF-7IP, ATXN7L2, BAFL, BAZ2A, BC032203, Bdf1, BRCAA1, BRD3, BRD9, Brpf1, BTBD14A, BTF3, C230099D08Rik, CARM1, CDY, CENP-A, CHD2, CLAMP, dCtBP, DDO, Dnmt3a, DPF1, EFO2, EG236663, EG385328, EG546205, EHMT1, EID-1, Elongin A, EMID2, Esa1, FBXO8, GAGE3, Glrp-1, H1T2, H2-M9, H2afb2, H2AL2, H2al2y, H2BFA, HDA4, HDA5, HDA6, HIC-1, Histone cluster 1 H1B, Histone cluster 1 H2A, Histone cluster 1 H2AA2, Histone cluster 1 H2AC, Histone cluster 1 H2AF, Histone cluster 1 H2AG, Histone cluster 1 H2AH, Histone cluster 1 H2AI, Histone cluster 1 H2AN, Histone cluster 1 H2AO, Histone cluster 1 H2B, Histone cluster 1 H2BA, Histone cluster 1 H2BC, Histone cluster 1 H2BH, Histone cluster 1 H2BI, Histone cluster 1 H2BP, Histone cluster 1 H3A, Histone cluster 1 H3B, Histone cluster 1 H3E, Histone cluster 1 H3I, Histone cluster 1 H4F, Histone cluster 1 H4G, Histone cluster 1 H4H, Histone cluster 1 H4J, Histone cluster 2 H2AA1, Histone cluster 2 H2AB, Histone cluster 2 H2AC, Histone cluster 2 H2BE, Histone cluster 2 H3A, Histone cluster 2 H3B, Histone cluster 2 H3C1, Histone cluster 2 H4, Histone cluster 3 H2A, Histone cluster 3 H2ba, Histone H1B, Histone H1X, Histone H2A.F, Histone H2A.V, Histone H2B.S, Histone H3.3B, HMG I, HMG-14, hnRNP H′/hnRNP H2, HoxD8, HPF1, HSV-1 ICP0, HTR3E, IFI-27, INO80B, INTS4, KIAA2026_9930021J03Rik, kismet, L3MBTL2, L3MBTL3, L3MBTL4, LANPL, LOC100041215, LOC100041241, LOC729454, MacroH2A, MAGE-A4, MAGE-A6, MAGE-G2, MBTD1, Med19, METTL1, METTL14, MLLT6, MORF4L1, MRG15, MRGBP, MSL-1, MTF-2, Mxi 1, N-CoR, NAP1L1, NAP1L4, NFATc2IP, NTS12, NY-ESO-1, PABPC4, Pdcd-1, Peregrin, periphilin 1, PHF16, PHF20, PRAME like-3, PRAME like-6, PRAME like-7, PRAMEF17, PRDM14, RASSF1, RBA-1, RbAp46, RBBP1, RCOR2, RNF20, SA-2, SAP 18, SAP 25_Sap25, SCML1, SCML2, SEBOX, Sec24, Set2, SETD6, SMARCD2, SPEN, SPT16, Spt7, SSRP1, STH1, Swi1, Swi3, SYT, TADA3L, TAF II p43, TBL1Y, TCEA3, TIGD5, Trimethyl Histone H3, WSTF, ZBTB38, ZCCHC18, ZFYVE28, ZNF222, ZNF295, ZNF33A, ZNF33B, ZNF345, ZNF396, ZNF408, ZNF469, ZNF498, ZNF579, ZNF597, ZNF709, ZNF828, and ZSCAN18.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MS-275, 1 mg | sc-279455 | 1 mg | $24.00 | |||
MS-275, 5 mg | sc-279455A | 5 mg | $90.00 | |||
MS-275, 25 mg | sc-279455B | 25 mg | $212.00 |