Molecular structure of Belinostat, CAS Number: 414864-00-9
Belinostat (CAS 414864-00-9)
Alternate Names:
(2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]acrylamide
Application:
Belinostat is a novel HDAC inhibitor
CAS Number:
414864-00-9
Molecular Weight:
318.35
Molecular Formula:
C15H14N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM. Belinostat inhibits the growth of tumor cells (A2780, HCT116, HT29, WIL, CALU-3, MCF7, PC3 and HS852) with IC50 from 0.2-0.66 μM. PD101 shows low activity in A2780/cp70 and 2780AD cells. Belinostat inhibits bladder cancer cell growth, especially in 5637 cells, which shows accumulation of G0-G1 phase, decrease in S phase, and increase in G2-M phase. Belinostat also shows enhanced tubulin acetylation in ovarian cancer cell lines. A recent study shows that Belinostat activates protein kinase A in a TGF-β signaling-dependent mechanism and decreases survivin mRNA.
Inhibitor of:
ΔN p63, 3100002L24Rik, 7420461P10Rik, Acatin, ALKB, ASF1B, ASXL1, ASXL3, BAF250a, BAGE4, BEND7, Blood Group H2, BORIS, BRMS1L, Btnl1, C11orf94, C14orf43, CD79A, CDY2, CHRAC17, Codanin-1, Dmap1, DNC, DNHD1, DNHD2, Dpy30, DUX3, DXBay18, EG434729, Evx-1, EZI, F8A2, FAM120AOS, FOXF2, GAGE, GAGE12G, GAGE4, GAS41, GATAD (GATA zinc finger domain containing), GATAD2A, Gm5894, gp91-phox, GPx-2, group III sPLA2, H2-A, H2-M10.1, H2BFWT, H3.Y histone 1, Hat2, hCAP-D3, HDA1, HDA2, HDA4, HDA5, HDA6, HDA7, HDAC1, HDAC11, HDAC2, HDAC3, HDAC6, HepC NS5b, Hils1, Histone B, Histone cluster 1 H1C, Histone cluster 1 H1E, Histone cluster 1 H2A, Histone cluster 1 H2AC, Histone cluster 1 H2AG, Histone cluster 1 H2AJ, Histone cluster 1 H2AK, Histone cluster 1 H2AM, Histone cluster 1 H2B, Histone cluster 1 H2BB, Histone cluster 1 H2BD, Histone cluster 1 H2BG, Histone cluster 1 H2BH, Histone cluster 1 H2BI, Histone cluster 1 H2BJ, Histone cluster 1 H2BL, Histone cluster 1 H2BM, Histone cluster 1 H3B, Histone cluster 1 H3H, Histone cluster 1 H4, Histone cluster 1 H4H, Histone cluster 1 H4L, Histone cluster 2 H2AA3, Histone cluster 2 H2AC, Histone cluster 2 H2BE, Histone cluster 2 H3C1, Histone cluster 2 H3C2, Histone cluster 2 H4, Histone cluster 3 H2BB, Histone H10, Histone H2A.Bbd, Histone H3, Histone H4, Histone Z, Lacrein, LIN-35, LIN-53, LOC665622, Lsh, MAGE-A11, MAGE-A9, MAGE-A9B, MAGE-B1, MAGE-B18, MAGE-B3, MAGE-F1, mage-k1, Mammaglobin A, MIER1, MIER3, Morc1, MRG15, mSin3A9, Mxi 1, NKAP, Npcd, Nup62-il4i1, NWD1, Obox5, OCIAD1, Olr1124, Olr119, Olr1264, Olr164, Olr168, Olr282, Olr517, Olr561, Olr655, Olr707, Olr744, OTTMUSG00000016789, OTTMUSG00000016790, OTTMUSG00000016887, OTTMUSG00000018481, OTTMUSG00000018888, p130 Cas, p150, PAGE-2, pan-Acetyl, PATE2, PCDHB13, PDIA2, PHF12, PHF21A, PI-9, Pi15, PLA2G4B, PLAC4, PRAMEF25, PRDM10, RBM35B, RhD, RP2, RP23-480B19.10, Rpd3, RuvC, SAP 130, SAP 30L, SCCA1, SDS3, SerpinB1, SIM2, Slfn11, SNF2L, SPNS2, SRRM5, Subh2bv, TADA3L, TAF II p68, TAF II p70, TIGD3, TOX3, Trav12d-3, TSSC4, TTC1, V1RH18, WDR79, WIZ, WT1, YDJC, YEATS2, ZCWPW1, ZFP605, Zfp868, ZMYM6NB, ZNF224, ZNF385A, and ZNF57.Activator of:
2900008C10Rik, 4930557A04Rik, ALKBH7, ATF-7IP, BAF, BAFL, BPTF, BRD3, CHD2, CHRAC15, EG546205, ELP3, HDA5, HHV-4 EBNA-2, HHV-4 LMP-1, HHV-4 ZEBRA, Histone cluster 1 H1B, Histone cluster 1 H2A, Histone cluster 1 H2AA2, Histone cluster 1 H2AC, Histone cluster 1 H2AN, Histone cluster 1 H2AO, Histone cluster 1 H2B, Histone cluster 1 H2BC, Histone cluster 1 H3F, Histone cluster 1 H3G, Histone cluster 1 H4, Histone cluster 1 H4H, Histone cluster 1 H4I, Histone cluster 1 H4M, Histone cluster 2 H2AA1, Histone cluster 2 H3B, Histone cluster 2 H4, Histone cluster 2 H4A, Histone cluster 3 H2ba, Histone H1B, Histone H1X, Histone H2A.V, Histone H2B, HMG-14, HoxD9, HPF1, KIAA2026_9930021J03Rik, L3MBTL2, LIN-54, MAGE-A2, MAGE-A4, MAGE-A6, MPHOSPH8, MRGBP, Mxi 1, NAP1L4, NFATc2IP, Peregrin, PKA, RASSF1, RbAp46, rotavirus C vp4, SCML2, Sec24, Siglec-9, SMARCD2, SPT16, SWI/SNF-B, Swi3, TRAIL, Trimethyl Histone H3, u4/u6 snRNP, WSTF, ZNF295, ZNF396, ZNF498, ZNF597, and ZNF828.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Belinostat, 10 mg | sc-269851 | 10 mg | $156.00 | |||
Belinostat, 100 mg | sc-269851A | 100 mg | $572.00 |